[1]许潜,俞赟丰,贺选玲,等.基于数据挖掘技术探讨王莘智教授治疗原发性干燥综合征的用药规律[J].西部中医药,2025,38(01):25-28.[doi:10.12174/j.issn.2096-9600.2025.01.06]
　XU Qian,YU Yunfeng,HE Xuanling,et al.Professor Wang Shenzhi′s Medication Laws of Treating Primary Sjogren′s Syndrome Based on Data Mining Technology[J].Western Journal of Traditional Chinese Medicine,2025,38(01):25-28.[doi:10.12174/j.issn.2096-9600.2025.01.06]
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基于数据挖掘技术探讨王莘智教授治疗原发性干燥综合征的用药规律()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年01期
页码:
25-28
栏目:
名医名家
出版日期:
2025-01-15

文章信息/Info

Title:
Professor Wang Shenzhi′s Medication Laws of Treating Primary Sjogren′s Syndrome Based on Data Mining Technology
作者:
许潜1, 俞赟丰1, 贺选玲2, 韦方敏3, 杨欣雨3, 王莘智,,
1.湖南中医药大学第一附属医院，湖南 长沙 410007
2.长沙市中医医院，湖南 长沙 410002
3.湖南中医药大学中医学院，湖南 长沙 410208
Author(s):
XU Qian1, YU Yunfeng1, HE Xuanling2, WEI Fangmin3, YANG Xinyu3, Director： WANG Shenzhi,,
1.The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, China
2.Changsha Hospital of Traditional Chinese Medicine, Changsha 410002, China
3.School of TCM Hunan University of Chinese Medicine, Changsha 410208, China
关键词:
原发性干燥综合征; 用药规律; 关联规则; 聚类分析
Keywords:
primary Sjogren’s syndrome; medication laws; association rules; cluster analysis
分类号:
R259
DOI:
10.12174/j.issn.2096-9600.2025.01.06
文献标志码:
A
摘要:
目的基于数据挖掘技术分析王莘智教授治疗原发性干燥综合征（primary Sjogren′s syndrome，pSS）的用药规律。 方法收集整理王莘智教授诊治pSS的临床医案，将处方录入Excel 2010并建立数据库，采用古今医案云平台（V2.3）开展中药的频次和聚类分析，采用SPSS Modeler 18.0软件进行关联规则分析。 结果共纳入王莘智教授治疗pSS的临证处方164首，中药107味，频率≥30%的核心中药分别为白术、黄芪、红花、当归、夏枯草、茯苓、柴胡、桃仁、桂枝、黄芩、苍术、甘草、玄参、枸杞子、附子、石膏、熟地黄。药性以温为主，药味以甘、辛、苦为主，归经以肝、肺、脾经为主，功效以安胎、润肠通便、明目、利水消肿等多见。关联规则获得茯苓-白术、夏枯草-白术、当归-白术等核心药物组合37项。聚类分析将药物分为5个聚类方，共奏补肾益精、燥湿健脾、滋阴清热、行气通络、健脾活血之功。 结论王莘智教授治疗pSS以健脾益气为核心治法，病情早期以清肝泻火为治法，病情后期以滋补肝肾为治法，同时配合清热生津、活血化瘀之法。
Abstract:
ObjectiveTo analyze professor Wang Shenzhi’s medication laws of treating primary Sjogren’s syndrome (pSS) based on data mining technology. MethodsProfessor Wang Shenzhi’s clinical cases of diagnosing and treating pSS were collected and sorted out, the prescriptions were entered into Excel 2010 to establish the database, the Ancient and Modern Medical Records Cloud Platform (V2.3) was used to conduct the frequency analysis and cluster analysis of herbs, association rules were analyzed using SPSS Modeler 18.0 software. ResultsA total of 164 clinical prescriptions of professor Wang Shenzhi for the treatment of pSS were included, with 107 herbs, the core herbs with the frequency of more than 30% were Baizhu (Atractylodes macrocephala Koidz.), Huangqi (Astragali radix), Honghua (Carthami flos), Danggui (Angelicae sinensis radix), Xiakucao (Prunellae spica), and Fuling [Poria cocos (Schw.) Wol], Chaihu (Bupleuri Radix), Taoren (Persicae semen), Guizhi (Cinnamomum cassia Presl), Huangqin (Scutellariae radix), Cangzhu(Atractylodis rhizoma), Gancao(Glycyrrhizae radix et rhizoma), Xuanshen (Scrophulariae radix), Gouqizi (Lycii fructus), Fuzi (Aconiti lateralis radix praeparata), Shigao(Gypsum fibrosum) and Shudihuang(Rehmanniae radix praeparata). The herbs are mainly warm in nature, sweet, pungent and bitter in taste, attributed to the meridians of liver, lung and spleen, most of which could stabilize the fetus, moisten the intestine and promote the bowel movement, brighten the eyes, promote diuresis and alleviate swelling. Association rules have yielded 37 core drug combinations including Fuling-Baizhu, Xiakucao-Baizhu, Danggui-Baizhu. Cluster analysis classified the drugs into five clusters, which together performed the functions of tonifying the kidney and benefiting the essence, drying the dampness and strengthening the spleen, nourishing Yin and clearing heat, moving Qi and dredging the collaterals, invigorating the spleen and activating blood. ConclusionProfessor Wang Shenzhi adopts invigorating spleen and benefiting Qi as the core therapeutic method in the treatment of pSS, clearing liver and purging fire in the early stage, nourishing liver and kidney in the late stage, meanwhile combining with clearing heat and generating fluid, promoting blood circulation and removing the stagnation.

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备注/Memo

备注/Memo:
许潜（1990—），女，硕士学位，主治医师。研究方向：风湿免疫疾病的临床诊治。湖南省自然科学基金（2020JJ4479）；湖南中医药科研计划项目（B2024065）；湖南省中医药科研计划项目（201778）。
更新日期/Last Update: 2025-01-15