[1]马芳,陈楚,闻新丽.溃疡性结肠炎与NF-κB信号通路作用机制的相关性研究进展[J].西部中医药,2025,38(02):100-103.[doi:10.12174/j.issn.2096-9600.2025.02.21]
　MA Fang,CHEN Chu,WEN Xinli.Research Progress in the Connection between Ulcerative Colitis and NF-κB Signaling Pathway[J].Western Journal of Traditional Chinese Medicine,2025,38(02):100-103.[doi:10.12174/j.issn.2096-9600.2025.02.21]
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溃疡性结肠炎与NF-κB信号通路作用机制的相关性研究进展()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年02期
页码:
100-103
栏目:
研究进展
出版日期:
2025-02-15

文章信息/Info

Title:
Research Progress in the Connection between Ulcerative Colitis and NF-κB Signaling Pathway
作者:
马芳1, 陈楚2, 闻新丽2
1.解放军联勤保障部队第926医院，云南 开远 661600
2.陕西省中医医院，陕西 西安 710003
Author(s):
MA Fang1, CHEN Chu2, WEN Xinli2
1.Hospital 926 of PLA Joint Logistics Support Force, Kaiyuan 661600, China
2.Shaanxi Provincial TCM Hospital, Xi’an 710003, China
关键词:
溃疡性结肠炎; 核因子B; 信号通路; 发病机制
Keywords:
ulcerative colitis; nuclear factor B; signaling pathway; pathogenesis
分类号:
R256.39
DOI:
10.12174/j.issn.2096-9600.2025.02.21
文献标志码:
A
摘要:
对核因子κB（nuclear factor kappa-B，NF-κB）信号通路及其与溃疡性结肠炎（ulcerative colitis，UC）的关系进行概述，指出肠道菌群紊乱以及细胞炎性反应是UC的关键病理过程，也是UC反复发作，甚至炎癌转化的重要机制，NF-κB信号通路介导了UC的发病机制，其与UC患者肠道炎症反应及免疫调节密切相关，治疗多用多糖类、氨基水杨酸盐和糖皮质激素及天然产物。
Abstract:
Intestinal flora disturbance and cellular inflammatory reaction are the key pathological courses of ulcerative colitis (UC), the important mechanism for UC recurrence, even inflammation-cancer transformation by generalizing nuclear factor κB (NF-κB) signaling pathway, and its relationship with UC, NF-κB signaling pathway has mediated the pathogenesis of UC, and it was closely related to inflammatory response and immunoregulation in UC patients, and the treatment mostly employs polysaccharide, aminosalicylate, glucocorticoid and natural products.

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备注/Memo

备注/Memo:
马芳（1995—），女，硕士学位，医师。研究方向：中医脾胃疾病的诊治。国家重点研发计划“中医药现代化研究”专项（2018YFC1705402）；陕西省中医医院院内博士启动基金（2021-02）。
更新日期/Last Update: 2025-02-15