[1]王懿娴,张瑞瑞,许彩凤,等.补肾化瘀方对肾虚血瘀型多囊卵巢综合征患者血清性激素水平及HIF-1α、Beclin-1、BNIP3的影响[J].西部中医药,2025,38(02):129-132.[doi:10.12174/j.issn.2096-9600.2025.02.28]
　WANG Yixian,ZHANG Ruirui,XU Caifeng,et al.Influence of Kidney-tonifying Stasis-removing Formula on the Levels of Serum Sex Hormone, HIF-1α, Beclin-1 and BNIP3 in Renal Deficiency and Blood Stasis Type of Polycystic Ovarian Syndrome Patients[J].Western Journal of Traditional Chinese Medicine,2025,38(02):129-132.[doi:10.12174/j.issn.2096-9600.2025.02.28]
点击复制

补肾化瘀方对肾虚血瘀型多囊卵巢综合征患者血清性激素水平及HIF-1α、Beclin-1、BNIP3的影响()
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年02期
页码:
129-132
栏目:
临床研究
出版日期:
2025-02-15

文章信息/Info

Title:
Influence of Kidney-tonifying Stasis-removing Formula on the Levels of Serum Sex Hormone, HIF-1α, Beclin-1 and BNIP3 in Renal Deficiency and Blood Stasis Type of Polycystic Ovarian Syndrome Patients
作者:
王懿娴1, 张瑞瑞1, 许彩凤2, 潘文3, 石璇1
1.兰州市中医医院，甘肃 兰州 730050
2.甘肃省中医院，甘肃 兰州 730050
3.甘肃省中医药研究院，甘肃 兰州 730050
Author(s):
WANG Yixian1, ZHANG Ruirui1, XU Caifeng2, PAN Wen3, SHI Xuan1
1.Lanzhou Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
2.Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
3.Gansu Provincial Academy of Chinese Medicine, Lanzhou 730050, China
关键词:
多囊卵巢综合征; 肾虚血瘀型; 自噬; 补肾化瘀方
Keywords:
polycystic ovarian syndrome; kidney deficiency and blood stasis pattern; autophagy; kidney-tonifying stasis-removing formula
分类号:
R271.14
DOI:
10.12174/j.issn.2096-9600.2025.02.28
文献标志码:
B
摘要:
目的观察补肾化瘀方对肾虚血瘀型多囊卵巢综合征（polycystic ovarian syndrome，PCOS）患者血清性激素水平及低氧诱导因子1α（hypoxia inducible factor-1α，HIF-1α）、肌球蛋白样BCL2结合蛋白（myosin-like BCL2 interacting protein，Beclin-1）、腺病毒E1B相互作用蛋白3（adenovirus E1B 19 kDa protein-interacting protein 3，BNIP3）的影响。 方法将肾虚血瘀型PCOS患者100例，按随机数字表法分为对照组和治疗组各50例。对照组予达英-35治疗，治疗组予补肾化瘀方治疗，两组均连续治疗3个月。比较两组患者治疗前后血清卵泡刺激素（follicle-stimulating hormone，FSH）、促黄体生成素（luteinizing hormone，LH）、睾酮（testosterone，T）、泌乳素（prolactin，PRL）、雌二醇（estradiol，E2）、孕酮（progesterone，P）的表达水平及HIF-1α、Beclin、BNIP3 mRNA表达水平。 结果治疗后两组患者血清LH、FSH、E2、T、P表达水平均降低，PRL表达水平升高（P＜0.05），治疗组改善程度优于对照组（P＜0.05）；HIF-1α、Beclin-1、BNIP3 mRNA表达水平均降低（P＜0.05），治疗组降低更明显（P＜0.05）。 结论补肾化瘀方能够改善肾虚血瘀型PCOS患者血清性激素表达水平，其可能在自噬调控中发挥作用，进而改善PCOS患者临床症状。
Abstract:
ObjectiveTo observe the effects of kidney-tonifying stasis-removing formula on the levels of serum sex hormone, HIF-1α, Beclin-1 and BNIP3 in patients with polycystic ovarian syndrome (PCOS) of kidney deficiency and blood stasis pattern. MethodsAll 100 cases of PCOS of kidney deficiency and blood stasis pattern were divided into the control group and the treatment group according to random number table method with 50 cases in each group. The control group was treated with ethinylestradiol and cyproterone acetate tablets, and the treatment group took the formula, and both groups were treated for three months continuously. To compare the expressions of FSH, LH, T, PRL, E2 and P, as well as the levels of HIF-1α, Beclin-1 and BNIP3 mRNA before and after the treatment between the two groups. ResultsAfter the treatment, the expressions of LH, FSH, E2, T and P were lowered, and the levels of PRL were raised (P<0.05), the improvements of the treatment group were better than these of the control group (P<0.05); the expressions of HIF-1α, Beclin-1 and BNIP3 mRNA were lowered (P<0.05), and the decrease of the treatment group was more apparent (P<0.05). ConclusionKidney-tonifying stasis-removing formula could improve the levels of serum sex hormone, which might play the role in regulating the autophagy, thereby mitigating the patients’ clinical symptoms.

相似文献/References:

[1]潘文,王贵霞,王晓萍.多囊卵巢综合征伴胰岛素抵抗的发病机制研究及中药干预作用[J].西部中医药,2012,25(12):121.
　PAN Wen,WANG Gui-xia,WANG Xiao-ping.Study on Pathogenesis of Polycystic Ovary Syndrome Complicated with Insulin Resistance and Intervention with Traditional Chinese Medicine[J].Western Journal of Traditional Chinese Medicine,2012,25(02):121.
[2]梁荣伟,刘新雄,李学余,等.穴位针刺加封闭联合辅助生殖技术对 PCOS 不孕患者激素水平的影响*[J].西部中医药,2013,26(02):98.
　LIANG Rongwei,LIU Xinxiong,LI Xueyu,et al.The Effects of Acupoint Block, Needling and Assisted Reproductive Technique on the Level of Hormone in Infertile Patients with PCOS[J].Western Journal of Traditional Chinese Medicine,2013,26(02):98.
[3]汪雪晴,曾敬.补肾调经方联合达英-35治疗多囊卵巢综合征疗效观察[J].西部中医药,2012,25(11):78.
　WANG Xue-qing,ZENG Jing.Clinical Observation on BuShen TiaoJingFang Combined with Ethinylestradiol and Cyproterone Acetate Tablets for Polycystic Ovary Syndrome[J].Western Journal of Traditional Chinese Medicine,2012,25(02):78.
[4]王针织,周丽虹,俞超芹△,等.补肾活血祛痰方治疗肥胖型与非肥胖型多囊卵巢综合征的疗效研究*[J].西部中医药,2014,27(04):1.
　WANG Zhenzhi,ZHOU Lihong,YU Chaoqin,et al.Study on Clinical Effects of Kidney-invigorating Blood-activating Phlegm-eliminating Prescription in Treating Polycystic Ovary Syndrome of Obesity Type and Non-obesity Type[J].Western Journal of Traditional Chinese Medicine,2014,27(02):1.
[5]苏庆华,张建伟△.多囊卵巢综合征中医证型与内分泌代谢指标相关性研究[J].西部中医药,2014,27(04):143.
　SU Qinghua,ZHANG Jianwei.Research on the Relativity between the Indexes of Metabolic Endocrinology and TCM Patterns of PCOS[J].Western Journal of Traditional Chinese Medicine,2014,27(02):143.
[6]康开彪,牛崇信,指导：潘文.潘文教授对多囊卵巢综合征中医病因的认识[J].西部中医药,2014,27(08):22.
[7]张翌蕾,潘文△,汪永娟,等.补肾化瘀方对PCOS大鼠血清激素水平的影响[J].西部中医药,2016,29(02):5.
　ZHANG Yilei,PAN Wen,WANG Yongjuan,et al.The Influence of BuShen HuaYu Prescription on the Levels of Hormone of PCOS Rats[J].Western Journal of Traditional Chinese Medicine,2016,29(02):5.
[8]雍志强,潘文△,张瑞瑞,等.补肾化瘀方对PCOS血清IKK表达的临床影响[J].西部中医药,2017,30(04):80.
　YONG Zhiqiang,PAN Wen,ZHANG Ruirui,et al.The Effects of BuShen HuaYu Prescription on Serum IKK Expression of PCOS Patients[J].Western Journal of Traditional Chinese Medicine,2017,30(02):80.
[9]卢如玲,古子娟,袁烁.补肾中药联合达英-35治疗多囊卵巢综合征疗效的Meta分析[J].西部中医药,2018,31(01):64.
　LU Ruling,GU Zijuan,YUAN Shuo.Meta Analysis of Clinical Effects of Kidney-tonifying Herbs Combined with Diane-35 in Treating Polycystic Ovarian Syndrome[J].Western Journal of Traditional Chinese Medicine,2018,31(02):64.
[10]周美英,李瑞丰.苍附导痰汤联合炔雌醇环丙孕酮治疗多囊卵巢综合征临床观察[J].西部中医药,2018,31(12):107.
　ZHOU Meiying,LI Ruifeng.Clinical Observation on CangFu DaoTan Decoction Joined with Ethinylestradiol and Cyproterone Acetate Tablets in Treating Polycystic Ovarian Syndrome[J].Western Journal of Traditional Chinese Medicine,2018,31(02):107.

备注/Memo

备注/Memo:
王懿娴（1980—），女，主治医师。研究方向：不孕症的中西医结合诊治。甘肃省自然科学基金（22JR5RA639）；甘肃省中医药管理局科研课题（GZK-2019-68）；兰州市卫生健康科技发展项目（2019-028）；兰州市人才创新创业项目（2019-RC-74）。
更新日期/Last Update: 2025-02-15