通窍止痛汤联合动脉瘤栓塞术治疗高龄动脉瘤性蛛网膜下腔出血患者临床观察-《西部中医药》

文章信息/Info

Title:: Clinical Observation on Orifice-opening Pain-relieving Decoction Joined with Aneurysm Embolization in the Treatment of Senile Aneurysmal Subarachnoid Hemorrhage

Author(s):: ZHANG Xiaoning, ZHANG Gaolian, GAO Yuguang, LIANG Weibin, XIE Weixing, WANG Gang, GUO Jianhui, ZENG Jing; The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China

Keywords:: subarachnoid hemorrhage; aneurysmal; senile; orifice-opening pain-relieving decoction; aneurysm embolization

摘要:: 目的探讨通窍止痛汤联合动脉瘤栓塞术治疗高龄动脉瘤性蛛网膜下腔出血患者的临床疗效。方法纳入60例高龄动脉瘤性蛛网膜下腔出血病例，按照随机数字表法分配成两组，对照组给予动脉瘤栓塞术治疗，联合组给予动脉瘤栓塞术联合通窍止痛汤治疗。观察两组治疗后临床疗效、不良反应及治疗前后格拉斯哥昏迷量表（Glasgow Coma Scale，GCS）评分、症状积分的变化情况。结果联合组总有效率［83.33%（25/30）］高于对照组76.67%（23/30）（P＜0.05）；在治疗后第3、7、14天，联合组GCS评分及症状积分的变化幅度大于对照组（P＜0.05）；两组在治疗期间均未发生明显不良反应。结论通窍止痛汤联合动脉瘤栓塞术治疗高龄动脉瘤性蛛网膜下腔出血，可明显减轻患者临床症状，提高患者术后生活质量。

Abstract:: ObjectiveTo explore clinical effects of orifice-opening pain-relieving (Tongqiao Zhitong) decoction and aneurysm embolization in the treatment of senile aneurysmal subarachnoid hemorrhage. MethodsSixty cases were included and divided into two groups according to random number table method, the control group was treated with aneurysm embolization, and the combination group accepted aneurysm embolization and oral administration of the decoction. To observe curative effects and adverse reaction after the treatment, GCS scores and symptom integrals before and after the treatment between the two groups. ResultsTotal effective rate of the combination group was [83.33%(25/30)], higher than [76.67%(23/30)] of the control group (P<0.05); On the 3rd, 7th and 14th day after the treatment, GCS scores and symptom integrals of the combination group were greater than these of the control group (P<0.05); no obvious adverse reaction happened during therapeutic period in the two groups. ConclusionOrifice-opening pain-relieving decoction and aneurysm embolization in the treatment of senile aneurysmal subarachnoid hemorrhage could obviously relieve clinical symptoms and improve the patients’ quality of life after the operation.

备注/Memo:: 张晓宁（1981—），男，硕士学位，副主任医师。研究方向：脑血管疾病的中西医防治。中央高校基本科研业务费专项资金资助-北京中医药大学2020年度重点攻关项目（2020-JYB-ZDGG-089）；北京中医药大学基本科研业务费“揭榜挂帅”项目（2022-JYB-JBRW-011）；北京中医药大学岐黄英才计划-北京市青年教学名师培育计划（J2023C01）。国家自然科学基金（81660782）；广西壮族自治区中医药管理局自筹经费课题（GZZC2020019）；广西中医药大学自然科学研究项目（2019MS021）。