[1]黄甫,李芳,叶苗青,等.断红丸加减治疗溃疡性结肠炎疗效观察[J].西部中医药,2025,38(09):123-127.[doi:10.12174/j.issn.2096-9600.2025.09.23]
　HUANG Fu,LI Fang,YE Miaoqing,et al.Clinical Observation on Modified Duanhong Pills in the Treatment of Ulcerative Colitis[J].Western Journal of Traditional Chinese Medicine,2025,38(09):123-127.[doi:10.12174/j.issn.2096-9600.2025.09.23]
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断红丸加减治疗溃疡性结肠炎疗效观察()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年09期
页码:
123-127
栏目:
临床研究
出版日期:
2025-09-15

文章信息/Info

Title:
Clinical Observation on Modified Duanhong Pills in the Treatment of Ulcerative Colitis
作者:
黄甫1, 李芳1, 叶苗青2, 张成明1, 鱼涛1, 张迎3
1.陕西省中医医院脾胃病一科，陕西 西安 710002
2.陕西省中医医院肝病科，陕西 西安 710002
3.西安市第八医院特管病区，陕西 西安 710061
Author(s):
HUANG Fu1, LI Fang1, YE Miaoqing2, ZHANG Chengming1, YU Tao1, ZHANG Ying3
1.First Department of Spleen and Stomach Diseases, Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi’an 710002, China
2.Hepatology Department, Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi’an 710002, China
3.Intensive Care Unit, Xi’an Eighth Hospital, Xi’an 710061, China
关键词:
溃疡性结肠炎; 肠道黏膜炎症; 断红丸; 中西结合疗法; 临床疗效
Keywords:
ulcerative colitis; intestinal mucosal inflammation; pills; integrative medicine therapy; clinical effects
分类号:
R256.33
DOI:
10.12174/j.issn.2096-9600.2025.09.23
文献标志码:
B
摘要:
目的探究断红丸加减治疗溃疡性结肠炎（ulcerative colitis，UC）的疗效及对腹痛和肠道黏膜炎症的影响。 方法将80例UC患者按照随机数字表法分为对照组和观察组，每组40例。对照组予西医综合治疗+美沙拉嗪，观察组在对照组治疗基础上予断红丸加减治疗。治疗8周后比较两组患者临床疗效及安全性，评估患者腹痛程度［疼痛相关数字评价量表（numerical rating scale，NRS）］、疾病严重程度［Sutherland疾病活动指数（disease activity index，DAI）评分］及疾病评分［肠镜评分（Baron评分）、黏膜组织评分（Geboes指数评分）］，测定肠道黏膜炎症指标［细胞间黏附分子1（intercellular cell adhesion molecule 1，ICAM-1）、基质金属蛋白酶9（matrix metalloprotein 9，MMP-9）、白细胞介素13（interleukin 13，IL-13）］水平。 结果观察组总有效率为92.5%（37/40），高于对照组的75.0%（30/40）（P＜0.05）；观察组患者治疗2周、4周时NRS评分均低于对照组（P＜0.05），治疗2周、4周及8周时DAI评分均低于对照组（P＜0.05）；两组患者Baron评分、Geboes指数评分及血清ICAM-1、MMP-9、IL-13水平均降低（P＜0.05），观察组低于对照组（P＜0.05）。 结论断红丸加减治疗UC疗效确切，可有效改善患者腹痛等临床症状以及肠道炎症反应，其作用机制可能与调节ICAM-1、MMP-9及IL-13等炎症指标水平相关。
Abstract:
ObjectiveTo explore curative effects of modified Duanhong pills in the treatment of UC and its influence on abdominal pain and intestinal mucosal inflammation. MethodsEighty UC patients were divided into the control group and the observation group in light of random number table method with 40 cases in each group. The control group were administered a combination therapy of Western medicine and mesalazine, whereas the observation group received modified Duanhong pills. To compare therapeutic effects and safety between the two groups after eight weeks of the treatment, and to evaluate the patients’ abdominal pain (NRS), the severity of disease (DAI scores), and disease scales (Baron scores), mucosal tissue score (Geboes scores), and to measure intestinal mucosal inflammation markers including ICAM-1, MMP-9 and IL-13. ResultsTotal effective rate of the observation group was 92.5% (37/40), higher than 75.0% (30/40) of the control group (P<0.05); NRS scores of the observation group were lower than these of the control group after two and four weeks of the treatment (P<0.05), DAI scores were lower than these of the control group after two, four and eight weeks of the treatment (P<0.05); Baron scores, Geboes scores, and the levels of ICAM-1, MMP-9 and IL-13 were reduced in the two groups (P<0.05), and the observation group was lower than the control group (P<0.05). ConclusionModified Duanhong pills exhibited marked clinical effects in the treatment of UC, which could effectively improve the patients’ clinical symptoms including abdominal pain and intestinal inflammatory response, its mechanism might be related to the regulation of the levels of ICAM-1, MMP-9 and IL-13.

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备注/Memo

备注/Memo:
黄甫（1984—），男，博士学位，副主任医师。研究方向：消化系统疾病的中医药防治。陕西省自然科学基础研究计划项目（2023-JC-QN-0977）；第七批全国老中医药专家学术经验继承工作项目（国中医药人教函〔2022〕76号）；陕西省第二批中医学术流派传承工作室建设项目“长安张氏升清降浊学术流派传承工作室”（陕中医药函〔2023〕84号）。
更新日期/Last Update: 2025-09-15