[1]李捷,郑雅峰,徐赛,等.TXNIP/NLRP3/GSDMD信号轴介导的细胞焦亡与糖耐量减低胰岛β细胞的关系及中医药防治研究进展[J].西部中医药,2025,38(10):104-107.[doi:10.12174/j.issn.2096-9600.2025.10.17]
　LI Jie,ZHENG Yafeng,XU Sai,et al.Association of TXNIP/NLRP3/GSDMD Axis-mediated Pyroptosis with Pancreatic Islet β Cells at IGT Phase, and Advances in TCM Prevention and Treatment[J].Western Journal of Traditional Chinese Medicine,2025,38(10):104-107.[doi:10.12174/j.issn.2096-9600.2025.10.17]
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TXNIP/NLRP3/GSDMD信号轴介导的细胞焦亡与糖耐量减低胰岛β细胞的关系及中医药防治研究进展()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年10期
页码:
104-107
栏目:
研究进展
出版日期:
2025-10-15

文章信息/Info

Title:
Association of TXNIP/NLRP3/GSDMD Axis-mediated Pyroptosis with Pancreatic Islet β Cells at IGT Phase, and Advances in TCM Prevention and Treatment
作者:
李捷1, 郑雅峰2, 徐赛1, 徐云生2
1.山东中医药大学，山东 济南 250014
2.山东中医药大学第二附属医院，山东 济南 250001
Author(s):
LI Jie1, ZHENG Yafeng2, XU Sai1, XU Yunsheng2
1.Shandong University of Traditional Chinese Medicine, Jinan 250014, China
2.The Second Affiliated Hospital to Shandong University of Traditional Chinese Medicine, Jinan 250001, China
关键词:
糖耐量减低; 细胞焦亡; 胰岛功能; 中医药
Keywords:
IGT; pyroptosis; pancreatic function; TCM
分类号:
R255.4
DOI:
10.12174/j.issn.2096-9600.2025.10.17
文献标志码:
A
摘要:
对TXNIP/NLRP3/GSDMD信号轴介导的细胞焦亡与糖耐量减低（impaired glucose tolerance，IGT）胰岛β细胞功能的关系，以及中医药防治IGT相关研究现状作一综述，指出IGT是2型糖尿病（type 2 diabetes mellitus，T2DM）的前期阶段，其发病机制主要包括胰岛β细胞功能受损、胰岛素抵抗和低度炎症反应等；脾虚肝郁、瘀热互结为IGT的核心病机，细胞焦亡则可引起阴阳失调导致IGT；保护β细胞数量，促进其增殖和减少焦亡成为治疗T2DM的关键，而靶向抑制TXNIP/NLRP3/GSDMD介导的细胞焦亡途径有望成为保护胰岛β细胞及治疗IGT的新策略。
Abstract:
We reviewed the correlation between TXNIP/NLRP3/GSDMD axis-mediated pyroptosis and pancreatic slet β cells at IGT phase, together with the current state of TCM prevention and treatment of IGT, IGT is the early stage of T2DM, and its pathogenesis mainly contain pancreatic slet β cells injury, insulin resistance and low-grade inflammation; spleen deficiency and liver Qi stagnation, heat intermingled with blood stasis become the core pathogenesis of IGT, pyroptosis lead to the imbalance between Yin and Yang, resulting in IGT; protecting the number of β cells, promoting its proliferation and reducing pyroptosis have been the key of treating T2DM, while targeted inhibition of TXNIP/NLRP3/GSDMD mediated pyroptosis is expected to be a new strategy for the protection of pancreatic slet β cells and the treatment of IGT.

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备注/Memo

备注/Memo:
李捷（1991—），女，博士学位，博士后，讲师。研究方向：内分泌代谢性疾病的中医药治疗。国家自然科学基金面上项目（81673966）；山东省自然科学基金（ZR2023QH119，ZR2024MH300）；山东省泰山学者工程专项经费项目（ts201712097）。
更新日期/Last Update: 2025-10-15