[1]郭瑞莹,张雪琰,于亚琳,等.益气活血清热法辅助常规西药治疗糖尿病合并冠心病的Meta分析及基础用药筛选[J].西部中医药,2025,38(12):58-65.[doi:10.12174/j.issn.2096-9600.2025.12.13]
　GUO Ruiying,ZHANG Xueyan,YU Yalin,et al.Meta-analysis of Benefiting-Qi Activating-blood Clearing-heat Method as Adjunctive Therapy and Western Medicine in Treating Diabetes Mellitus Complicated with Coronary Heart Disease and the Screening of Essential Medicines[J].Western Journal of Traditional Chinese Medicine,2025,38(12):58-65.[doi:10.12174/j.issn.2096-9600.2025.12.13]
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益气活血清热法辅助常规西药治疗糖尿病合并冠心病的Meta分析及基础用药筛选()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年12期
页码:
58-65
栏目:
二次研究
出版日期:
2025-12-15

文章信息/Info

Title:
Meta-analysis of Benefiting-Qi Activating-blood Clearing-heat Method as Adjunctive Therapy and Western Medicine in Treating Diabetes Mellitus Complicated with Coronary Heart Disease and the Screening of Essential Medicines
作者:
郭瑞莹1,2, 张雪琰1, 于亚琳1, 李慧欣1, 粟裕冬1, 田丁阳1, 董敏1, 董波2
1.山东中医药大学，山东 济南 250014
2.山东第一医科大学附属省立医院，山东 济南 250021
Author(s):
GUO Ruiying1,2, ZHANG Xueyan1, YU Yalin1, LI Huixin1, SU Yudong1, TIAN Dingyang1, DONG Min1, DONG Bo2
1.Shandong University of Traditional Chinese Medicine, Jinan 250014, China
2.Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China
关键词:
糖尿病; 冠心病; 益气活血清热; 糖代谢; 脂代谢; Meta分析
Keywords:
diabetes mellitus; coronary heart disease; benefiting- activating-blood and clearing-heat; glycometabolism; lipid metabolism; Meta analysis
分类号:
R255.4
DOI:
10.12174/j.issn.2096-9600.2025.12.13
文献标志码:
A
摘要:
目的探究益气活血清热法辅助常规西药治疗2型糖尿病合并冠心病的疗效、安全性及基础用药筛选。 方法通过计算机检索电子数据库，收集关于益气活血清热法辅助常规西药治疗2型糖尿病合并冠心病的随机对照研究，内容涵盖临床总有效率、心绞痛改善率、心电图有效率，血糖、血脂指标变化，炎症因子指标变化等。由两名研究者独立进行文献筛选、资料提取和质量评价，运用RevMan 5.4软件开展Meta分析。同时，对Meta分析纳入研究涉及的方剂及中药进行药物频次统计与用药种类归纳。 结果共纳入12篇文献，涉及883例患者。分析结果表明，益气活血清热法辅助常规西药治疗2型糖尿病合并冠心病，可显著提升临床总有效率、心绞痛改善率及心电图有效率，有效调节血糖、血脂指标，降低炎症因子水平。基础用药分析显示，使用频率最高的中药依次为黄芪、甘草、麦冬、大黄、黄连、丹参；使用频率最高的药物类别为补益类、活血类、清热类中药。 结论相较于单纯西药常规治疗，益气活血清热法辅助常规西药治疗在提高2型糖尿病合并冠心病的临床总有效率、心绞痛改善率、心电图有效率，改善糖脂代谢紊乱，减轻炎症反应等方面具有优势，且安全性良好。
Abstract:
ObjectiveTo explore clinical effects and the safety of benefiting-Qi activating-blood and clearing-heat method combined with Western medicine in the treatment of type two diabetes mellitus (T2DM) and coronary heart disease (CHD), and the screening of essential medicines. MethodsRandomized controlled trials (RCTs) on benefiting-Qi activating-blood and clearing-heat method and Western medicine in the treatment of T2DM and CHD were collected by computer retrieval of electronic databases, the contents covered clinical total effecctive rate, the improvement rate of angina pectoris, ECG effective rate, the changes of blood glucose, blood lipid and inflammatory factors. Two researchers independently conducted literature screening, data extraction and quality evaluation, RevMan 5.4 was applied to launch Meta analysis. Meanwhile, frequency statistics of drugs and types of medication were performed on Meta-analysis included prescriptions and Chinese medicine involved in the study. ResultsThe study included 12 articles, involving 883 patients. The analysis results demonstrated that the combination therapy in the treatment of T2DM and CHD could remarkably improve clinical total effective rate, the improvement rate of angina pectoris, ECG effective rate, effectively regulate blood glucose and blood lipid, and decrease the levels of inflammatory factors. The analysis of essential medicines displayed that the most frequently used Chinese medicines were Huangqi (Astragali radix), Gancao(Glycyrrhizae radix et rhizoma), Maidong (Ophiopogonis radix), Dahuang (Rhei Radix ET Rhizoma), Huanglian (Coptidis rhizoma) and Danshen (Salviae miltiorrhizae radix et rhizoma); the sorts of the medicine in the highest frequency were tonics, the ones of activating-blood, and clearing heat. ConclusionCompared with single use of Western medicine, the combination of benefiting-Qi activating-blood and clearing-heat method and Western medicine has advantages in improving clinical total effective rate, the improvement rate of angina pectoris, ECG effective rate, regulating glucose and lipid metabolism disorder and alleviating inflammatory reaction with good safety.

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备注/Memo

备注/Memo:
国家自然科学基金（81570729）；泰山学者基金（ts20190979）。郭瑞莹（1996—），女，硕士学位，医师。研究方向：中西医结合心系疾病研究。
更新日期/Last Update: 2025-12-15