《四部医典》含乌头组方应用规律研究-《西部中医药》

文章信息/Info

Title:: A Study on the Application Patterns of Classical Formulations Containing Aconite in the Four Tantras

作者:: 格知加^1,2, 索朗拉宗¹, 尕藏卓玛³, 尼玛次仁¹; 1.西藏藏医药大学，西藏拉萨 850000
2.青海省藏医院，青海西宁 810007
3.西藏自治区食品药品检验研究所，西藏拉萨 850000

Author(s):: GE Zhijia^1,2, Suolang Lazong¹, Gazang Zhuoma³, Nima Ciren¹; 1.Tibet University of Tibetan Medicine, Lasa 850000, China
2.Qinghai Tibetan Hospital, Xining 810007, China
3.Institute for Food and Drug Control of Tibet Autonomous Region, Lasa 850000, China

摘要:: 目的对《四部医典》中含乌头的组方进行研究，为临床合理用药提供参考。方法收集《四部医典》记载组方中含乌头的方剂，建立数据库，使用Excel进行方剂、配伍、脉诊分析，使用R version 4.0.3软件进行关联规则分析和聚类分析。结果共筛选出134首方剂，208味藏药，在《四部医典》中多用于中毒病和热病，将使用频次≥20次的药物分为解毒药、赤巴药、坏血药、清热药、疗伤药和滋补药。关联规则分析得到35首含乌头的药组。聚类分析得到10组药对，其中含有乌头的药对同质性较高。结论乌头在临床使用中多与解毒药、赤巴药、坏血药、清热药、疗伤药和滋补药配伍，组合功效和主治疾病具有针对性和临床实用性。

Abstract:: ObjectiveTo provide the reference for clinical rational drug use by studying the classical formulations containing aconite in the Four Tantras. MethodsThe formulations containing aconite in the Four Tantras were collected to establish the database, Excel was applied to analyze the prescriptions, compatibility and pulse taking, and R version 4.0.3 was used to conduct association rules analysis and cluster analysis. ResultsAll 134 formulations and 208 Tibetan herbs were identified, and most of them were commonly used for treating poisoning disorders and febrile diseases in the Four Tantras, and the drugs with a frequency of use≥20 times could be divided into detoxifying agents, bile (pitta)-regulating medicines, blood-cleansing medicines, heat-clearing medicines, wound-healing medicines and tonic medicine. Association rule analysis has yielded 35 drug combinations containing aconite. Cluster analysis obtained ten herb combinations, among them, the herb pairs containing aconite exhibited a high degree of homogeneity. ConclusionIn clinical practice, aconite is frequently combined with detoxifying agents, bile (pitta)-regulating medicines, blood-cleansing medicines, heat-clearing medicines, wound-healing medicines and tonic medicine, its therapeutic effects and indications are well-targeted and demonstrate high clinical utility.