[1]赵永强,李俊江,徐志伟,等.克淋复方颗粒凝胶喷剂煎煮加水量精准控制模型构建及产业化应用验证[J].西部中医药,2026,39(02):1-4.[doi:10.12174/j.issn.2096-9600.2026.02.01]
　ZHAO Yongqiang,LI Junjiang,XU Zhiwei,et al.Construction of a Precision Control Model for Decoction Water Volume of Kelin Gel Spray and Verification for Industrial Application[J].Western Journal of Traditional Chinese Medicine,2026,39(02):1-4.[doi:10.12174/j.issn.2096-9600.2026.02.01]
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克淋复方颗粒凝胶喷剂煎煮加水量精准控制模型构建及产业化应用验证()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
39
期数:
2026年02期
页码:
1-4
栏目:
质量分析
出版日期:
2026-02-15

文章信息/Info

Title:
Construction of a Precision Control Model for Decoction Water Volume of Kelin Gel Spray and Verification for Industrial Application
作者:
赵永强, 李俊江, 徐志伟, 潘志强, 李季文, 贾云鹏
甘肃省中医院，甘肃 兰州 730050
Author(s):
ZHAO Yongqiang, LI Junjiang, XU Zhiwei, PAN Zhiqiang, LI Jiwen, JIA Yunpeng
Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
关键词:
克淋凝胶喷剂; 加水量; 得液量; 水蒸气蒸发系数; 煎煮工艺
Keywords:
gel spray; water addition; liquid yield; water vapor evaporation coefficient; decoction process
分类号:
R283.6
DOI:
10.12174/j.issn.2096-9600.2026.02.01
文献标志码:
A
摘要:
目的建立颗粒凝胶喷剂精准化煎煮控制体系，通过优化加水量计算公式和煎煮参数，解决工业化生产中得液量波动超过8%的技术瓶颈。 方法测定煎药容器水蒸气蒸发系数。以克淋凝胶喷剂复方为对象，按公式计算总加水量，分别设置一煎、二煎加水比例60∶40、70∶30、80∶20进行煎煮。测定复方实际吸水量、得液量、相对密度及出膏率。基于实际吸水量引入吸水率校正系数，优化加水量公式。以得液量偏离度、校正相对密度和出膏率为指标，优选加水比例。 结果优化后加水量公式为：加水量=理论吸水量×0.73+预期得液量+水蒸气蒸发量+煎药机损耗量。加水比例60∶40时，得液量偏离度最低（0.38%），校正相对密度（1.0185）和总出膏率（7.66%）最高，显著优于70∶30和80∶20比例。 结论优化后的公式结合60∶40的加水比例，可实现对克淋凝胶喷剂煎煮加水量和得液量的科学、精准控制，提高有效成分煎出率，可为不同煎药设备应用该公式提供校正依据。
Abstract:
ObjectiveTo establish a precision decoction control system for granular gel spray through the optimization of the water addition formula and decoction parameters, thereby resolving the technical bottleneck of liquid yield fluctuation exceeding 8%. MethodsThe water vapor evaporation coefficient of the herbal decoction container was determined. The compound formulation of Kelin gel spray was chosen as the targets, the total water addition volume was calculated using the specified formula. Based on this, the spray was decocted with the water addition ratio for the first and second decoctions set at 60:40, 70:30 and 80:20, respectively. To determine the actual water absorption, liquid yield, relative density and extract yield of the compound formulation. Based on the actual water absorption, a water absorption correction factor was introduced, thereby optimizing the water addition formula. The water addition ratio was optimized using deviation of liquid yield, corrected relative density and extract yield. ResultsAfter optimization, water addition formula was: water addition=theoretical water absorption×0.73+expected liquid yield+water vapor evaporation+decoction machine loss. When the water addition ratio was at 60:40, deviation of liquid yield (0.38%), corrected relative density (1.0185) and total extract yield (7.66%) were the highest, remarkably better than these when the water addition ratio was at 70:30 and 80:20. ConclusionThe optimized formula, when applied with a water addition ratio of 60:40, enabled precise and scientific control of water addition and liquid yield for Kelin gel spray. This approach significantly improved the extraction yield of active ingredients and established a reliable calibration basis for applying the formula across different decoction devices.

相似文献/References:

[1]王丽,麻秀萍.不同功效中药吸水性对密闭煎药机加水量的影响[J].西部中医药,2014,27(05):19.
　WANG Li,MA Xiuping.Effects of Water Absorption of Drugs with Different Properties on Added Water of Closed Decoction Machine[J].Western Journal of Traditional Chinese Medicine,2014,27(02):19.

备注/Memo

备注/Memo:
甘肃省中医药管理局项目（GZKP-2022-14）；甘肃省药品科研项目（2023GSMPA040）；兰州市医疗卫生专项（2023-2-93）。赵永强（1968─），男，主任医师。研究方向：泌尿外科疾病诊治与研究。
更新日期/Last Update: 2026-02-15