[1]史扬,柳红芳,郭燕,等.糖尿病肾病肾精亏虚证与TGF-β1、Klotho、MMP-9、TIMP-1的相关性研究[J].西部中医药,2026,39(02):136-140.[doi:10.12174/j.issn.2096-9600.2026.02.26]
　SHI Yang,LIU Hongfang,GUO Yan,et al.Correlational Study between Diabetic Nephropathy with Kidney Essence Deficiency Pattern, and TGF-β1, Klotho, MMP-9 and TIMP-1[J].Western Journal of Traditional Chinese Medicine,2026,39(02):136-140.[doi:10.12174/j.issn.2096-9600.2026.02.26]
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糖尿病肾病肾精亏虚证与TGF-β1、Klotho、MMP-9、TIMP-1的相关性研究()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
39
期数:
2026年02期
页码:
136-140
栏目:
临床研究
出版日期:
2026-02-15

文章信息/Info

Title:
Correlational Study between Diabetic Nephropathy with Kidney Essence Deficiency Pattern, and TGF-β1, Klotho, MMP-9 and TIMP-1
作者:
史扬1, 柳红芳1, 郭燕1, 安至超2, 宿家铭1, 蒋威1, 南茜3
1.北京中医药大学东直门医院，北京 100700
2.北京市房山区中医院，北京 102499
3.北京中医药大学第三附属医院，北京 100029
Author(s):
SHI Yang1, LIU Hongfang1, GUO Yan1, AN Zhichao2, SU Jiaming1, JIANG Wei1, NAN Qian3
1.Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China
2.Fangshan District Hospital of Traditional Chinese Medicine, Beijing 102499, China
3.The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China
关键词:
糖尿病肾病; 肾精亏虚; 纤维化因子
Keywords:
diabetic nephropathy; kidney essence deficiency; fibrosis markers
分类号:
R277.5
DOI:
10.12174/j.issn.2096-9600.2026.02.26
文献标志码:
B
摘要:
目的探讨糖尿病肾病（diabetic nephropathy，DN）肾精亏虚证与血清纤维化因子转化生长因子β1（Transforming growth factor-β1，TGF-β1）、可溶性αKlotho蛋白（soluble αKlotho protein，Klotho）、基质金属蛋白酶9（matrix metalloproteinase 9，MMP9）、组织金属蛋白酶抑制剂1（tissue inhibitors of metalloproteinase 1，TIMP-1）水平的相关性。 方法收集2型糖尿病患者85例，其中单纯2型糖尿病患者29例，DN Ⅲ、Ⅳ期患者56例（肾精亏虚证组36例、非肾精亏虚证组20例）的一般资料及临床生化指标，检测患者血清纤维化因子水平，比较DN组与糖尿病组患者一般资料和血清纤维化因子水平的差异；并分析DN肾精亏虚证组与非肾精亏虚证组各项指标差异。 结果与糖尿病组比较，DN组血清TGF-β1、TIMP-1水平升高（P＜0.01），Klotho水平及MMP9/TIMP-1水平降低（P＜0.05）。与DN非肾精亏虚证组比较，DN肾精亏虚证组血清TGF-β1、TIMP-1水平升高（P＜0.05），血清Klotho水平降低（P＜0.01）。DN肾精亏虚证评分与TGF-β1呈正相关（r=0.426，P＜0.01），DN肾精亏虚证评分与Klotho呈负相关（r=-0.375，P＜0.01），DN肾精亏虚证组评分与MMP9、TIMP-1及MMP9/TIMP-1未见明显相关性（P＞0.05）。DN肾精亏虚证组的血红蛋白（hemoglobin，HGB）、肾小球滤过率（estimated glomerular filtration rate，eGFR）水平低于非肾精亏虚证组（P＜0.01），血清尿素氮（blood urea nitrogen，BUN）、血清肌酐（serum creatinine，SCr）、24 h尿蛋白定量（24-hour urine protein quantification，24 h UTP）水平高于非肾精亏虚证组（P＜0.05）。 结论肾精亏虚可能是DN发生发展的重要内在病机，血清TGF-β1、Klotho水平与肾精亏虚证可能具有一定相关性。
Abstract:
ObjectiveTo discuss the correlation between diabetic nephropathy (DN) with kidney essence deficiency pattern, and the levels of TGF-β1, Klotho, MMP-9 and TIMP-1 in the serum. MethodsWe collected the general information and clinical biochemical indicators of 85 patients suffering type 2 diabetes mellitus (T2DM), among them, there were 29 cases of uncomplicated T2DM, 56 cases of stage Ⅲ and stage Ⅳ DN (36 cases of kidney essence deficiency pattern, and 20 cases of non kidney essence deficiency pattern), to detect the levels of serum fibrosis factors, and to compare the differences in general information and the levels of serum fibrosis factors between DN group and T2DM group; and a comparative analysis of all indicators was performed between the DN group with kidney essence deficiency pattern and the DN group with non kidney essence deficiency pattern. ResultsThe elevation in the levels of TGF-β1, and TIMP-1 was observed in DN group when compared with T2DM group (P<0.01), and DN group demonstrated the decreased levels of Klotho, MMP-9/TIMP-1 (P<0.05). DN group of kidney essence deficiency pattern exhibited the elevated levels of TGF-β1, and TIMP-1 when it was compared with DN group of non kidney essence deficiency pattern (P<0.05), and the decrease in serum Klotho (P<0.01). The scores of DN group of kidney essence deficiency pattern were positively related to TGF-β1 (r=0.426, P<0.01), while the scores of DN group of kidney essence deficiency pattern were negatively related to Klotho (r=-0.375, P<0.01), no significant correlation was observed between the scores of DN group of kidney essence deficiency pattern, and the levels of MMP9, TIMP-1, and MMP-9/TIMP-1 (P>0.05). The levels of HGB and eGFR in DN group of kidney essence deficiency pattern were lower than these in DN group of non kidney essence deficiency pattern (P<0.01), while the levels of BUN, SCr and 24h UTP were higher than these in DN group of non kidney essence deficiency pattern (P<0.05). ConclusionKidney essence deficiency might be the important pathogenesis in the incidence and development of DN, serum levels of TGF-β1 and Klotho may be correlated with the kidney essence deficiency pattern.

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备注/Memo

备注/Memo:
国家自然科学基金（82004297）；北京中医药大学基本科研业务费项目（2020-JYB-XJSJJ-062）。史扬（1995—），女，博士学位，主治医师。研究方向：中医药防治肾病。
更新日期/Last Update: 2026-02-15