[1]缪小祥,周美娟,邱峰.龙血通络胶囊对椎动脉支架内再狭窄率及血脂与血栓弹力图的影响[J].西部中医药,2026,39(04):112-116.[doi:10.12174/j.issn.2096-9600.2026.04.24]
　MIU Xiaoxiang,ZHOU Meijuan,QIU Feng.Effects of Longxue Tongluo Capsules on In-Stent Restenosis Rate, Blood Lipids, and Thromboelastography in the Vertebral Artery[J].Western Journal of Traditional Chinese Medicine,2026,39(04):112-116.[doi:10.12174/j.issn.2096-9600.2026.04.24]
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龙血通络胶囊对椎动脉支架内再狭窄率及血脂与血栓弹力图的影响()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
39
期数:
2026年04期
页码:
112-116
栏目:
临床研究
出版日期:
2026-04-15

文章信息/Info

Title:
Effects of Longxue Tongluo Capsules on In-Stent Restenosis Rate, Blood Lipids, and Thromboelastography in the Vertebral Artery
作者:
缪小祥1, 周美娟1, 邱峰2
1.如皋市中医院，江苏 如皋 226500
2.南京医科大学附属脑科医院脑血管病救治中心，江苏 南京 210000
Author(s):
MIU Xiaoxiang1, ZHOU Meijuan1, QIU Feng2
1.Rugao Hospital of Traditional Chinese Medicine, Rugao 226500, China
2.Cerebrovascular Disease Treatment Center, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210000, China
关键词:
椎动脉支架内再狭窄; 龙血通络胶囊; 血脂; 血栓弹力图; 介入治疗
Keywords:
in-stent restenosis rate in the vertebral artery; capsules; blood lipids; thromboelastography; interventional therapy
分类号:
R286
DOI:
10.12174/j.issn.2096-9600.2026.04.24
文献标志码:
B
摘要:
目的探讨龙血通络胶囊对椎动脉支架植入术后患者支架内再狭窄的预防作用，以及对血脂、血栓弹力图参数的影响。 方法将107例椎动脉开口支架植入患者按随机数字表法分为对照组（54例）和观察组（53例）。对照组给予阿司匹林、硫酸氢氯吡格雷联合阿托伐他汀治疗，观察组在对照组治疗基础上加服龙血通络胶囊。分别于术后1、3个月随访，比较两组血脂水平、血栓弹力图参数及再狭窄率。 结果与治疗前相比，观察组治疗1个月时低密度脂蛋白水平下降（P＜0.05）；治疗3个月时，两组低密度脂蛋白水平及观察组总胆固醇水平均明显下降（P＜0.01）；与对照组相比，观察组治疗3个月时低密度脂蛋白、总胆固醇水平下降更显著（P＜0.05）。在血栓弹力图参数方面，与治疗前相比，观察组治疗1个月时血凝块最大强度下降（P＜0.05）；治疗3个月时，两组凝血因子反应时间延长，纤维蛋白原功能及血凝块最大强度值均下降（P＜0.05）。与对照组相比，观察组治疗3个月后凝血因子反应时间及血凝块最大强度值改善更明显（P＜0.05）。治疗3个月后，观察组椎动脉开口支架再狭窄发生率［1.88（1/53）］低于对照组［12.96（7/54）］（P＜0.05）。 结论在常规抗血小板治疗基础上加用龙血通络胶囊，可更有效降低患者血脂水平、抑制血小板聚集、改善血液高凝状态，对降低椎动脉支架植入术后支架内再狭窄发生率具有预防作用。
Abstract:
ObjectiveTo discuss preventive effect of Longxue Tongluo capsules on in-stent restenosis in patients after vertebral artery stent implantation, and its impact on blood lipids and thromboelastography parameters. MethodsA total of 107 patients undergoing vertebral artery ostial stent implantation were divided into a control group (54 cases) and an observation group (53 cases) using a random number table method. The control group was treated with Aspirin, Clopidogrel Bisulfate, and Atorvastatin, while the observation group was additionally given Longxue Tongluo capsules based on the treatment regimen of the control group. Follow-up was conducted at one and three months after the procedure to compare the blood lipid levels, thromboelastography parameters, and restenosis rate between the two groups. ResultsCompared with before treatment, the low-density lipoprotein (LDL) level in the observation group decreased at one month of treatment (P<0.05). At three months of treatment, LDL levels in both groups and the total cholesterol (TC) level in the observation group were significantly decreased (P<0.01). Compared with the control group, the decreases in LDL and TC levels in the observation group were more significant at three months of treatment (P<0.05). In terms of thromboelastography parameters, compared with before treatment, the maximum clot firmness in the observation group decreased at one month of treatment (P<0.05). At three months of treatment, the clotting time (R time) was prolonged in both groups, while fibrinogen function and maximum clot firmness values were decreased (P<0.05). Compared with the control group, the improvements in clotting time and maximum clot firmness in the observation group were more significant after three months of treatment (P<0.05). After three months of treatment, the incidence of in-stent restenosis at the vertebral artery ostium in the observation group [1.88% (1/53)] was lower than that in the control group [12.96% (7/54)] (P<0.05). ConclusionAdding Longxue Tongluo capsules to conventional antiplatelet therapy can more effectively reduce blood lipid levels, inhibit platelet aggregation, and improve blood hypercoagulability. This has a preventive effect on reducing the incidence of in-stent restenosis after vertebral artery stent implantation.

备注/Memo

备注/Memo:
南京市医学科技发展资金（QRX17086）；南京市医学科技发展专项资金重点项目（ZKX23039）。缪小祥（1985—），男，主治医师。研究方向：脑病的中医诊治。
更新日期/Last Update: 2026-04-15