[1]邢涛,宋焱峰,董林,等.凝血酶对脊髓组织毒性损伤机制及水蛭素的干预作用[J].西部中医药,2011,24(11):7-7.
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凝血酶对脊髓组织毒性损伤机制及水蛭素的干预作用
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
24
期数:
2011年11期
页码:
7-7
栏目:
出版日期:
2011-11-22

文章信息/Info

作者:
邢涛;宋焱峰;董林;王志勇;
甘肃省中医院;兰州大学基础医学院;
关键词:
脊髓损伤凝血酶凝血酶受体1水蛭素
摘要:
目的:研究凝血酶对大鼠脊髓组织毒性损伤机制及水蛭素的干预作用。方法:用免疫组化法检测凝血酶受体1(PAR-1)在脊髓组织中的表达,显微镜和MOTAC病理图像分析仪检测PAR-1免疫组化阳性细胞数;HE染色病理切片观察脊髓组织形态学的改变。结果:实验各组PAR-1阳性表达及脊髓组织水肿在脊髓损伤后6小时开始,72小时达到高峰(P<0.01);水蛭素可明显降低各时相PAR-1阳性表达(P<0.01或P<0.05)。结论:凝血酶对脊髓组织有细胞毒性损伤作用,且于72小时时损伤最严重;凝血酶抑制剂水蛭素可以选择性和特异性抑制凝血酶对脊髓组织的损伤。

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更新日期/Last Update: 2011-11-22