[1]万娜,李朝平.当归对先兆流产大鼠模型流产率及血清β-HCG、血浆TXB_2含量的影响[J].西部中医药,2011,24(11):11-11.
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当归对先兆流产大鼠模型流产率及血清β-HCG、血浆TXB_2含量的影响
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《西部中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
24
期数:
2011年11期
页码:
11-11
栏目:
出版日期:
2011-11-22

文章信息/Info

作者:
万娜;李朝平;
甘肃中医学院;
关键词:
先兆流产当归血清β-HCG血浆TXB2
摘要:
目的:探讨妇科常用药"当归"对先兆流产大鼠模型的作用机制及影响。方法:选取50只大鼠(孕6~8天),运用随机数字表随机分为5组:正常组,模型对照组,当归高、中、低剂量组,每组各10只。按照3.75 mg/kg对除正常组之外其余各组大鼠灌服米非司酮片,建立先兆流产大鼠模型。造模成功后,对各中药组灌服当归水煎剂,观察该药对先兆流产大鼠模型流产率、血清β-HCG、血浆TXB2含量的影响。结果:先兆流产大鼠模型在给予当归水煎剂灌服后,中、低剂量组大鼠流产率均低于模型对照组,有统计学意义(P<0.01);当归中、低剂量组的血清β-HCG含量高于模型对照组,有统计学意义(P<0.05);当归中、低剂量组血浆TXB2含量低于模型对照组,有统计学意义(P<0.05)。结论:①先兆流产大鼠模型在给予当归水煎液灌服后,中、低剂量组流产率明显下降。②当归可升高先兆流产大鼠模型血清β-HCG含量并可降低血浆TXB2的含量。③当归对先兆流产模型大鼠的妊娠结局无不良影响,可用于先兆流产的治疗。

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更新日期/Last Update: 2011-11-22