[1]孙洁慧,赵景文,左 进. IL-1β，IL-8在使用复方苦参洗剂治疗小鼠瘙痒症中的表达[J].西部中医药,2012,25(10):18-19.
　SUN Jie-hui,ZHAO Jing-wen,ZUO Jin. Expression of IL-1β and IL-8 During the Course of Appling Compound Kuh-seng Lotion to Mice with Pruritus[J].Western Journal of Traditional Chinese Medicine,2012,25(10):18-19.
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 IL-1β，IL-8在使用复方苦参洗剂治疗小鼠瘙痒症中的表达()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
25
期数:
2012年10期
页码:
18-19
栏目:
出版日期:
2012-10-15

文章信息/Info

Title:
 Expression of IL-1β and IL-8 During the Course of Appling Compound Kuh-seng Lotion to Mice with Pruritus
文章编号:
1004-6852(2012)10-0018-02
作者:
 孙洁慧1，赵景文1，左 进2
 1 甘肃中医学院，甘肃 兰州 730030； 2 甘肃省中医院
Author(s):
 SUN Jie-hui1, ZHAO Jing-wen1, ZUO Jin2
 1 Gansu University of Traditional Chinese Medicine, Lanzhou 730030, China;
2 Gansu Province Hospital of Traditional Chinese Medicine
关键词:
 ; ［关键词］ 白介素-1β; 白介素-8; 瘙痒; 复方苦参洗剂
Keywords:
 ; interleukin-1β;  interleukin-8;  pruritus;  compound kuh-seng lotion
分类号:
R758.3
文献标志码:
A
摘要:
 目的： 观察复方苦参洗剂对细胞因子白介素-1β(IL-1β)和白介素-8(IL-8)引起皮肤瘙痒的治疗作用，初步探讨复方苦参洗剂治疗皮肤瘙痒的作用机理。方法：采用磷酸组胺建立小鼠瘙痒模型，用即用型 SABC法免疫组化染色后对各皮损部位的切片进行IL-1β、IL-8含量检测。结果：与空白组和基质组相比，复方苦参洗剂高、中、低各剂量组IL-1β、IL-8灰度值均降低，其差异有统计学意义(P＜0.05)；与炉甘石洗剂组相比，复方苦参洗剂高、中剂量组IL-1β、IL-8灰度值降低，其差异有统计学意义(P＜0.05)。结论：复方苦参洗剂可明显抑制瘙痒模型小鼠皮肤组织中IL-1β和IL-8的含量，其改变程度与用药剂量有密切关系。
Abstract:
 Objective: To observe the function of compound kuh-seng lotion on cytokine (interleukin-1β and interleukin-8) which induced pruritus and initially explore the mechanism of compound kuh-seng lotion in treating pruritus. Method: Pruritic mice model was established with histamine phosphate. Contents of IL-1β and IL-8 in slices were detected with SABC method. Result: Compared with blank group and stroma group, grey levels of IL-1β and IL-8 lowered in high, middle and low dose groups of compound kuh-seng lotion, the differences suggested statistical meaning(P＜0.05); compared with calamine lotion, grey levels of IL-1β and IL-8 decreased in high and middle groups of compound kuh-seng lotion, the differences demonstrated statistical meaning(P＜0.05). Conclusion: Compound kuh-seng lotion can obviously inhibit the contents of IL-1β and IL-8 in skin tissue of pruritic mice, the degree is closely associated with the dose.

参考文献/References:

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备注/Memo

备注/Memo:
 收稿日期：2012-04-10
作者简介：孙洁慧(1986—)，女，硕士研究生。研究方向：肛肠疾病的中医诊治。
更新日期/Last Update: 2012-10-29