[1]万兵,符海燕,尹江涛,等.大黄对合并呼吸衰竭重症胰腺炎的治疗作用及对 IL-6、CRP 的影响*[J].西部中医药,2012,25(11):33-35.
 WAN Bin,FU Hai-yan,YIN Jiang-tao,et al.Therapeutic Effects of DaHuang on Severe Acute Pancreatitis Complicated with Respiratory Failure and Its Impact on Expressions of IL-6 and CRP[J].Western Journal of Traditional Chinese Medicine,2012,25(11):33-35.
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大黄对合并呼吸衰竭重症胰腺炎的治疗作用及对 IL-6、CRP 的影响*
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
25
期数:
2012年11期
页码:
33-35
栏目:
方药·药理研究
出版日期:
2012-11-15

文章信息/Info

Title:
Therapeutic Effects of DaHuang on Severe Acute Pancreatitis Complicated with Respiratory Failure and Its Impact on Expressions of IL-6 and CRP
文章编号:
1004-6852(2012)11-0033-03
作者:
万兵符海燕尹江涛刘朔张建国孙志伟万英朱会萍
江苏大学附属医院,江苏 镇江 212001
Author(s):
WAN Bin FU Hai-yan YIN Jiang-tao LIU Shuo ZHANG Jian-guo SUN Zhi-wei WAN Ying ZHU Hui-ping
Affiliated Hospital of Jiangsu University, ZhenJiang 212001, China
关键词:
SAP呼吸衰竭肠功能障碍氧合指数IL-6C 反应蛋白大黄
Keywords:
SAP respiratory failure gastrointestinal disorder oxygenation index IL-6 CRP DaHuang
分类号:
R259
文献标志码:
A
摘要:
目的:观察大黄对合并呼吸衰竭重症胰腺炎(SAP)患者的治疗作用及对 IL-6、CRP 的影响。方法:将 56 例入住 ICU 伴呼吸衰竭的 SAP 患者分为大黄治疗组和对照组,观察 2 组患者氧合指数变化、机械通气天数、胃肠功能障碍持续时间、体温恢复时间及 CRP、IL-6 的变化。结果:2 组患者第 1、3 天的血清 CRP、IL-6水平相比无统计学差异(P>0.05);第 5 天血清 CRP、IL-6 水平大黄治疗组低于对照组(P<0.05),第 7 天,2组比较有统计学差异(P<0.01)。第1、3、5、7天PaO2/FiO2大黄治疗组高于对照组,2组相比有统计学差异(P<0.05)。大黄治疗组胃肠功能恢复所需时间与对照组比较,有统计学差异(P<0.01);体温恢复时间大黄组与对照组相比,有统计学差异(P<0.05);机械通气时间大黄治疗组与对照组比较有统计学差异(P<0.01)。结论:大黄可有效改善胃肠功能障碍并减弱炎症反应,抑制炎症因子释放,并能加速肺损伤的恢复,减少机械通气时间。
Abstract:
Objective: To approach therapeutic effects of DaHuang (Rhubarb) for patients with severe acute pancreatitis (SAP) complicated with respiratory failure and its impact on expressions of IL-6 and CRP. Method: All 56 patients were randomly divided into treatment group of DaHuang and control group. Changes of CRP and IL-6,recovery time of body temperature, duration of gastrointestinal disorder, days of mechanical ventilation and changes of oxygenation index of patients were observed. Result: Comparisons between both groups demonstrated no statistical difference in the levels of CRP and IL-6 in serum at the 1st and 3rd day (P> 0.05); levels of CRP and IL-6 of treatment group were lower than that of control group at the 5th day (P< 0.05), comparison between both groups at the 7th day showed statistical difference (P< 0.01). Treatment group was higher than control group in PaO2/FiO2 at the 3rd, 5th and 7th day, comparisons between both groups had statistical difference (P< 0.05). Comparisons between both groups showed significant difference in recovery time of gastrointestinal function (P< 0.05); statistical difference also existed in time of mechanical ventilation (P< 0.01). Conclusion: DaHuang could effectively improve gastrointestinal disorder, alleviate inflammatory reactions, inhibit the release of cytokines, accelerate the recovery of pulmonary injury and reduce the time of mechanical ventilation.

参考文献/References:

[1] 徐有富.重症急性胰腺炎的非手术治疗进展[J].中国医药科学,2011,1(6):28-29. [2] 吴伟健,何炎尧.乌司他汀注射液对重症急性胰腺炎患者血清 TNF-琢、IL-10 的影响[J].中国当代医药,2012,19(8):40-41. [3] 中华医学会消化病学分会胰腺疾病学组.中国急性胰腺炎诊治指南(草案)[J].中华消化杂志,2004,24(3):190-192. [4] Rey C,Los Arcos M,Concha A,et al.Procalcitonin and C-reactive protein as mark ers of systemic inflammatory response syndrome severity in critically ill children[J].Intensive Care Med,2007,33(3):477-484. [5] Lausevic Z,Lausevic M,Trbojevic-Stankovic,et al.Predicting multiple organ failure in patients with severe trauma[J].Can J Surg,2008,51(2):97-102. [6] Malmstrom ML,Hansen MB,Andersen AM,et al.Cytokines and organ failure in acute pancreatitis:inflammatory response in acute pancreatitis[J].Pancreas,2012,41(2):271-277. [7] 贺俊萍,李春风.清胰解毒方治疗重症急性胰腺炎的临床研究[J].甘肃中医,2010,23(2):25-27. [8] 杨春平,朱锦腾,郑献敏.中西医结合治疗急性弥漫性腹膜炎合并中毒性肠麻痹 30 例临床观察[J].河北中医,2011,32(9):1359-1361. [9] 李书印.急性胰腺炎肠屏障功能衰竭 47 例治疗观察[J].中国现代医生,2008,46(33):147-148. [10]沙建平,祝彼得,赵艳,等.丹参对兔重症急性胰腺炎早期中性粒细胞与内皮细胞粘附机制的研究[J].中国中西医结合消化杂志,2004,12(1):3-5. [11]严鸣,杨兴易,陈德昌,等.大黄对重症急性胰腺炎并发急性呼吸窘迫综合征的治疗作用[J].胃肠病学,2001,6(2):94-96. [12]闫兆平,陈晓理,张正.大黄与小鼠小肠抗生素肽表达变化的相关性研究[J].中国中西医结合杂志,2011,31(7):946-950.

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备注/Memo

备注/Memo:
收稿日期:2012-05-09 * 基金项目:镇江市科技支撑计划(社会发展)指导性项目(编号 FZ2011047) 作者简介:万兵(1976—),男,硕士学位,主治医师。研究方向:肠衰竭及多器官功能不全综合征的治疗。
更新日期/Last Update: 2012-11-15