[1]万兵,符海燕,尹江涛,等.大黄对合并呼吸衰竭重症胰腺炎的治疗作用及对 IL-6、CRP 的影响*[J].西部中医药,2012,25(11):33-35.
 WAN Bin,FU Hai-yan,YIN Jiang-tao,et al.Therapeutic Effects of DaHuang on Severe Acute Pancreatitis Complicated with Respiratory Failure and Its Impact on Expressions of IL-6 and CRP[J].Western Journal of Traditional Chinese Medicine,2012,25(11):33-35.
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大黄对合并呼吸衰竭重症胰腺炎的治疗作用及对 IL-6、CRP 的影响*
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
25
期数:
2012年11期
页码:
33-35
栏目:
出版日期:
2012-11-15

文章信息/Info

Title:
Therapeutic Effects of DaHuang on Severe Acute Pancreatitis Complicated with Respiratory Failure and Its Impact on Expressions of IL-6 and CRP
文章编号:
1004-6852(2012)11-0033-03
作者:
万兵符海燕尹江涛刘朔张建国孙志伟万英朱会萍
江苏大学附属医院,江苏 镇江 212001
Author(s):
WAN Bin, FU Hai-yan, YIN Jiang-tao, LIU Shuo, ZHANG Jian-guo, SUN Zhi-wei, WAN Ying, ZHU Hui-ping
Affiliated Hospital of Jiangsu University, ZhenJiang 212001, China
关键词:
SAP呼吸衰竭肠功能障碍氧合指数IL-6C 反应蛋白大黄
Keywords:
SAP respiratory failure gastrointestinal disorder oxygenation index IL-6 CRP DaHuang
分类号:
R259
文献标志码:
A
摘要:
目的:观察大黄对合并呼吸衰竭重症胰腺炎(SAP)患者的治疗作用及对 IL-6、CRP 的影响。方法:将 56 例入住 ICU 伴呼吸衰竭的 SAP 患者分为大黄治疗组和对照组,观察 2 组患者氧合指数变化、机械通气天数、胃肠功能障碍持续时间、体温恢复时间及 CRP、IL-6 的变化。结果:2 组患者第 1、3 天的血清 CRP、IL-6水平相比无统计学差异(P>0.05);第 5 天血清 CRP、IL-6 水平大黄治疗组低于对照组(P<0.05),第 7 天,2组比较有统计学差异(P<0.01)。第1、3、5、7天PaO2/FiO2大黄治疗组高于对照组,2组相比有统计学差异(P<0.05)。大黄治疗组胃肠功能恢复所需时间与对照组比较,有统计学差异(P<0.01);体温恢复时间大黄组与对照组相比,有统计学差异(P<0.05);机械通气时间大黄治疗组与对照组比较有统计学差异(P<0.01)。结论:大黄可有效改善胃肠功能障碍并减弱炎症反应,抑制炎症因子释放,并能加速肺损伤的恢复,减少机械通气时间。
Abstract:
Objective: To approach therapeutic effects of DaHuang (Rhubarb) for patients with severe acute pancreatitis (SAP) complicated with respiratory failure and its impact on expressions of IL-6 and CRP. Method: All 56 patients were randomly divided into treatment group of DaHuang and control group. Changes of CRP and IL-6,recovery time of body temperature, duration of gastrointestinal disorder, days of mechanical ventilation and changes of oxygenation index of patients were observed. Result: Comparisons between both groups demonstrated no statistical difference in the levels of CRP and IL-6 in serum at the 1st and 3rd day (P> 0.05); levels of CRP and IL-6 of treatment group were lower than that of control group at the 5th day (P< 0.05), comparison between both groups at the 7th day showed statistical difference (P< 0.01). Treatment group was higher than control group in PaO2/FiO2 at the 3rd, 5th and 7th day, comparisons between both groups had statistical difference (P< 0.05). Comparisons between both groups showed significant difference in recovery time of gastrointestinal function (P< 0.05); statistical difference also existed in time of mechanical ventilation (P< 0.01). Conclusion: DaHuang could effectively improve gastrointestinal disorder, alleviate inflammatory reactions, inhibit the release of cytokines, accelerate the recovery of pulmonary injury and reduce the time of mechanical ventilation.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2012-05-09 * 基金项目:镇江市科技支撑计划(社会发展)指导性项目(编号 FZ2011047) 作者简介:万兵(1976—),男,硕士学位,主治医师。研究方向:肠衰竭及多器官功能不全综合征的治疗。
更新日期/Last Update: 2012-11-15