[1]李秀娟,李芸△,吴平安,等.大黄总蒽醌超滤纯化工艺研究*[J].西部中医药,2012,25(12):22-24.
 LI Xiu-juan,LI Yun,WU Ping-an,et al.On Purification of Total Anthraquinone in Chinese Rhubarb with Ultrafiltration[J].Western Journal of Traditional Chinese Medicine,2012,25(12):22-24.
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大黄总蒽醌超滤纯化工艺研究*
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
25
期数:
2012年12期
页码:
22-24
栏目:
出版日期:
2012-12-15

文章信息/Info

Title:
On Purification of Total Anthraquinone in Chinese Rhubarb with Ultrafiltration
文章编号:
1004-6852(2012)12-0022-03
作者:
李秀娟1李芸2△吴平安2魏舒畅2
1 甘肃省中医院,甘肃 兰州 730050;2 甘肃中医学院
Author(s):
LI Xiu-juan1, LI Yun2△, WU Ping-an2, WEI Shu-chang2
1 Gansu Province Hospital of Traditional Chinese Medicine, Lanzhou 730050, China; 2 Gansu University of Traditional Chinese Medicine
关键词:
大黄总蒽醌超滤纯化工艺
Keywords:
Chinese Rhubarb total anthraquinone ultrafiltration purification process
分类号:
R284.2
文献标志码:
A
摘要:
目的:研究超滤技术应用于大黄总蒽醌的纯化工艺。方法:用水提取大黄,提取液离心分离得滤液,以超滤压力、药液温度、料液浓度为考察因素,以总蒽醌含量为考察指标,采用均匀设计优化超滤工艺参数。结果:优化得到大黄总蒽醌超滤工艺为药液以3000r/min离心处理12分钟,用分子截留量100 K的膜,超滤压力为0.05-0.09MPa,药液温度25-40℃,药液浓缩程度1∶10-1∶30,pH6.0,超滤膜先用tween-80(5g/L)处理10分钟。结论:优化所得超滤工艺与未超滤相比有较高的总蒽醌得率和纯度。
Abstract:
Objective: To study the purification of total anthraquinone in Chinese Rhubarb with ultrafiltration.Method: Ultrafiltration process was optimized with homogeneous design by adopting total anthraquinone as index,pressure, temperature and the concentration as parameters. Chinese rhubarb was extracted with water and the extract was obtained with centrifuge. Result: The optimal condition of purification process for total anthraquinone in Chinese rhubarb was: the liquid centrifuged for 12minutes at the speed 3 000r/min, with ultrafiltration membrane of 100K retention molecular weight, the pressure 0.05 to 0.09 Mpa and the temperature 25 to 40℃, the concentration ratio 1 : 10 to 1 : 30, pH 6.0, the ultrafiltration membrane was handled with tween-80 (5 g/L) for 10 minutes. Conclusion:Compared with non-ultrafiltration, the yield and pureness of total anthraquinone obtained from the optimized ultrafiltration process are higher.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2012-08-07 * 基金项目:甘肃省教育厅第二批科研项目(编号 0806B-07) 作者简介:李秀娟(1972—),女,主管药师,硕士学位。研究方向:临床药学与药物分析。 △通讯作者:李芸(1973—),女,副教授,硕士学位。研究方向:药物分析。
更新日期/Last Update: 1900-01-01