[1]杨宏武,李亮,唐晓勇△.茴香枳术汤对实验性大鼠粘连性肠梗阻组织NO、DAO的影响[J].西部中医药,2013,26(03):28-30.
 YANG Hongwu,LI Liang,TANG Xiaoyong.Effects of HuiXiang ZhiZhuTang on NO and DAO of Experimental Rats with Adhesive Intestinal Obstruction[J].Western Journal of Traditional Chinese Medicine,2013,26(03):28-30.
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茴香枳术汤对实验性大鼠粘连性肠梗阻组织NO、DAO的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年03期
页码:
28-30
栏目:
方药·药理研究
出版日期:
2013-03-15

文章信息/Info

Title:
Effects of HuiXiang ZhiZhuTang on NO and DAO of Experimental Rats with Adhesive Intestinal Obstruction
文章编号:
1004-6852(2013)03-0028-03
作者:
杨宏武1李亮2唐晓勇2△
1 甘肃中医学院,甘肃 兰州 730000;2 甘肃省中医院
Author(s):
YANG Hongwu1 LI Liang2 TANG Xiaoyong2△
1 Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China; 2 Gansu Province Hospital of Traditional Chinese Medicine
关键词:
肠梗阻粘连性茴香枳术汤组织一氧化氮二胺氧化酶
Keywords:
intestinal obstruction adhesive HuiXiang ZhiZhuTang tissue NO DAO
分类号:
R285.6
文献标志码:
A
摘要:
目的:观察茴香枳术汤对大鼠粘连性肠梗阻组织一氧化氮(NO)含量、二胺氧化酶(DAO)活性的影响。方法:制备大鼠粘连性肠梗阻模型,随机分为正常组,模型组,大承气汤组,茴香枳术汤低、中、高剂量组。给予相应药物治疗,分别于治疗后第 3、5、7 天,共 3 个时间点,每时间点 6 只,切取病变肠管匀浆,取上清液,放免法测定组织 NO 含量与 DAO 活性。结果:与正常组比较,模型组组织 NO 含量增加(P<0.05),DAO 活性下降(P<0.05);与模型组比较,大承气汤组、茴香枳术汤低剂量组、茴香枳术汤中剂量组和茴香枳术汤高剂量组组织 NO 含量显著下降(P<0.05),DAO 活性增加(P<0.05)。结论:茴香枳术汤对粘连性肠梗阻具有良好的治疗作用,其作用机制与保护肠屏障功能有关。
Abstract:
Objective: To observe the effects of HuiXiang ZhiZhuTang on NO contents and DAO activity of rats with adhesive intestinal obstruction. Method: Models were established and randomized into normal group,model group, Da ChengQiTang group, low, moderate and high dose groups of HuiXiang ZhiZhuTang. The rats were given with corresponding medicine, NO content and DAO activity were measured with radioimmunoassay after treating at the 3 rd, 5 th and 7 th day. Result: Compared with normal group, NO content increased and DAO activity decreased in model group (P<0.05); compared with model group, NO content lowered and DAO activity increased in Da ChengQiTang group, low, moderate and high dose groups of HuiXiang ZhiZhuTang (P<0.05). Conclusion: HuiXiang ZhiZhuTang is effective in treating adhesive intestinal obstruction, the mechanism might be related to protect intestinal barrier.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2012-10-20 作者简介:杨宏武(1969—),男,在职硕士研究生,主任医师。研究方向:肠道肿瘤的中西医结合诊治。 △通讯作者:唐晓勇(1968—),男,主任医师,甘肃省普外科专业委员会腹腔镜学组委员。研究方向:胃肠和周围血管病的微创治疗。
更新日期/Last Update: 2013-03-15