[1]何国华,钞建峰.通闭益气活血汤治疗血栓闭塞性脉管炎的临床研究[J].西部中医药,2013,26(03):88-90.
　HE Guohua,CHAO Jianfeng.Clinical Study on TongBi YiQi HuoXueTang in the Treatment for Thromboangiitis Obliterans[J].Western Journal of Traditional Chinese Medicine,2013,26(03):88-90.
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通闭益气活血汤治疗血栓闭塞性脉管炎的临床研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年03期
页码:
88-90
栏目:
出版日期:
2013-03-15

文章信息/Info

Title:
Clinical Study on TongBi YiQi HuoXueTang in the Treatment for Thromboangiitis Obliterans
文章编号:
1004-6852(2013)03-0088-03
作者:
何国华，钞建峰
甘肃省中医院，甘肃 兰州 730050
Author(s):
HE Guohua, CHAO Jianfeng
Gansu Province Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
关键词:
血栓闭塞性脉管炎; 通闭益气活血汤; 血液流变学
Keywords:
thromboangiitis;  TongBi YiQi HuoXueTang;  blood rheology
分类号:
R543
文献标志码:
B
摘要:
目的：观察通闭益气活血汤治疗血栓闭塞性脉管炎(TAO)的临床疗效。方法：将 60 例患者随机分为治疗组和对照组各 30 例。2 组患者均采用注射用己酮可可碱，200 mg/d(首次 100 mg)加入 0.9%氯化钠注射液 250 mL 静脉滴注，3 小时输毕。对照组给予复方丹参片，3 片 / 次，3 次 /d，口服。治疗组给予通闭益气活血汤，100 mL/ 次，3 次 /d，口服。2 组均以治疗 15 天为 1 个疗程，治疗 4 个疗程后观察疗效。结果：治愈率治疗组为 30.00%，对照组 20.00%。总有效率治疗组为 86.67%，对照组为 66.67%。2 组治愈率和总有效率比较，差异有显著性(P＜0.05)。全血黏度、血浆黏度和红细胞聚集及变形指数 2 组治疗后较治疗前有降低(P＜0.05)，且治疗组降低幅度较对照组明显(P＜0.05)。2 组均未见明显不良反应。结论：通闭益气活血汤治疗 TAO 临床疗效显著，不良反应小。
Abstract:
Objective: To observe clinical effects of TongBi YiQi HuoXueTang in treating thromboangiitis obliterans (TAO). Method: Sixty patients were allocated into the treatment group and the control group equally. Both groups received intravenous dripping of pentoxifylline for injection, 200 mg/d (100mg first) and 0.9% sodium chloride injection and finished in three hours. The control group took compound DanShen tablets orally, three tablets each time, three times each day. The treatment group took TongBi YiQi HuoXueTang orally, 100mL/time, three times each day. One course of treatment was 15 days. After four courses of treatment, clinical effects were observed.Result: Cure rates of the treatment group and the control group were 30.00% and 20.00%. Total effective rates of both groups were 86.67% and 66.67%. Comparisons of both groups had difference in cure rate and total effective rate and they were significant (P＜ 0.05). Whole blood viscosity, plasma viscosity, erythrocyte aggregation and deformation index were lower after treating than before treating (P＜ 0.05), and the range of the treatment group was more significant than that of the control group(P＜ 0.05). Both groups did not appear remarkable adverse reaction. Conclusion: TongBi YiQi HuoXueTang could gain remarkable clinical effects in treating TAO with minor adverse reaction.

参考文献/References:

［1］ 吴在得，吴肇汉.外科学［M］.7 版.北京：人民卫生出版社，2008：605． ［2］ 陈柏楠，侯玉芬，周涛.周围血管疾病中西医诊疗学［M］.北京：中国中医药出版社，1999：251-252，257. ［3］ 国家中医药管理局.中医病证诊断疗效标准［M］.南京：南京大学出版社，1994：53. ［4］ 唐博，罗文军.血栓闭塞性脉管炎发病机制的研究进展［J］.国外医学：外科学分册，2004，31(5)：295-297. ［5］ Edo N，Miyai K，Ogata S，et al.Thromboangitis obliterans with multiple large vessel involvement：case report and analysis of immunophenotypes［J］.Cardiovasc Pathol，2010，19(1)：59-62. ［6］ 金星，王茂华，吴学君，等.吸烟与大鼠血栓闭塞性脉管炎的关系探讨［J］.山东医药，2011，51(6)：29-30. ［7］ 夏永潮，徐文科，李妍怡，等.佛手益气活血汤治疗 52 例中风后遗症疗效观察［J］.中西医结合杂志，1991，11(12)：736-737． ［8］ 何立.当归对神经和免疫系统作用的研究现状与展望［J］.时珍国医国药，2007，18(9)：2282-2284. ［9］ 鲁建武，宋金春，曾俊芬.佛手散对大鼠血液流变性的影响［J］.中国医院药学杂志，2009，29(5)：356-358.

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备注/Memo

备注/Memo:
收稿日期：2012-10-20 作者简介：何国华(1963—)，男，副主任医师。研究方向：肝胆疾病的中西医诊治。
更新日期/Last Update: 2013-03-15