[1]林晓芬,黄燕璇.益肾汤联合厄贝沙坦及胰激肽原酶治疗早期糖尿病肾病的疗效观察[J].西部中医药,2013,26(07):68-70.
　LIN Xiaofen,HUANG Yanxuan.Clinical Observation on YiShenTang Combined with Irbesartan and Pancreatic Kininogenase in the Treatment for Early Diabetic Nephropathy[J].Western Journal of Traditional Chinese Medicine,2013,26(07):68-70.
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益肾汤联合厄贝沙坦及胰激肽原酶治疗早期糖尿病肾病的疗效观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年07期
页码:
68-70
栏目:
出版日期:
2013-07-15

文章信息/Info

Title:
Clinical Observation on YiShenTang Combined with Irbesartan and Pancreatic Kininogenase in the Treatment for Early Diabetic Nephropathy
文章编号:
1004-6852(2013)07-0068-03
作者:
林晓芬，黄燕璇
汕头市龙湖区下蓬医院内科，广东 汕头 515065
Author(s):
LIN Xiaofen, HUANG Yanxuan
Department of Internal Medicine of Xiapeng Hospital in Longhu District, Shantou 515065, China
关键词:
糖尿病肾病; 早期; 益肾汤; 厄贝沙坦; 胰激肽原酶
Keywords:
early diabetic nephropathy;  YiShenTang;  irbesartan;  pancreatic kininogenase
分类号:
R587.2
文献标志码:
A
摘要:
目的：观察益肾汤联合厄贝沙坦、胰激肽原酶治疗早期糖尿病肾病(DN)的疗效。方法：将66例早期DN患者随机分为治疗组(n=36)和对照组(n=30)。对照组使用厄贝沙坦联合胰激肽原酶进行治疗，治疗组在对照组的基础上加用益肾汤治疗。2组疗程均为2个月。观察并比较2组患者的治疗效果和治疗前后平均动脉压(MAP)、空腹血糖(FBG)、血肌酐(Scr)、尿素氮(BUN)、尿白蛋白排泄率(UAER)、尿β2-微球蛋白(β2-MG)的变化。结果：总有效率治疗组为88.9%，对照组为76.7%，2组差异虽无显著性(P＞0.05)，但治疗组总有效率高于对照组。2组治疗前后Scr、BUN保持稳定。与治疗前比较，治疗1个月后2组MAP、UAER及β2-MG均明显下降(P＜0.01)。与治疗1个月后比较，治疗2个月后2组UAER及β2-MG水平仍继续下降(P＜0.05或P＜0.01)。与对照组比较，治疗组治疗1、2个月后UAER、β2-MG下降程度更明显(P＜0.01)。结论：益肾汤联合厄贝沙坦、胰激肽原酶治疗早期DN患者疗效确切，且能更有效地降低UAER和β2-MG水平，是延缓早期DN进展的有效办法。
Abstract:
Objective: To observe curative efficacy of YiShenTang, irbesartan and pancreatic kininogenase in treating early diabetic nephropathy(DN). Method: All 66 patient were randomized into the treatment group (n=36) and the control group(n=30). The patients in the control group were administered with irbesartan and pancreatic kininogenase, while the treatment group took YiShenTang. Two months were one course of treatment. The changes of urinary beta2-microglobulin (β2-MG), urinary albumin excretion rate (UAER), usea nitrogen (BUN), serum creatinine (Scr), fasting blood glucose (FBG) and mean arterial pressure (MAP) were compared before and after treating in both groups, as well as clinical effects. Result: Total effective rate of the treatment group was 88.9%, higher than 76.7% of the control group, the difference was insignificant(P＞0.05). Scr and BUN of both groups were stable before and after treating. Compared with before treating, MAP, UAER and β2-MG were lowered remarkably after treating for one month(P＜0.01). Compared with after treating for one month, UAER and β2-MG of both groups continued to lower after treating for two months (P＜0.05 or P＜0.01). Compared with the control group, UAER and β2-MG of both groups were decreased more significantly in the treatment group(P＜0.01). Conclusion: YiShenTang, irbesartan and pancreatic kininogenase could obtain notable effects in treating patients with early DN, it could effectively decrease the levels of UAER and β2-MG, it is an effective method to delay the progress of DN.

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备注/Memo

备注/Memo:
收稿日期：2013-02-01 作者简介：林晓芬(1975—)，女，主治医师。研究方向：糖尿病、肾病的中西医结合诊治。
更新日期/Last Update: 2013-07-15