[1]李雪嫣,张李峰,桂曼曼,等.复方玉屏风散对小鼠细胞免疫力的增强作用研究[J].西部中医药,2013,26(08):11-14.
　LI Xueyan,ZHANG Lifeng,GUI Manman,et al.Study on Compound YuPingFengSan Oral Liquid Improving Cellular Immunity of Mice[J].Western Journal of Traditional Chinese Medicine,2013,26(08):11-14.
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复方玉屏风散对小鼠细胞免疫力的增强作用研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年08期
页码:
11-14
栏目:
出版日期:
2013-08-15

文章信息/Info

Title:
Study on Compound YuPingFengSan Oral Liquid Improving Cellular Immunity of Mice
文章编号:
1004-6852(2013)08-0011-04
作者:
李雪嫣，张李峰，桂曼曼，鲍英存，杜娟，蒲建中，程卫东
兰州大学基础医学院中西医结合研究所，甘肃 兰州 730000
Author(s):
LI Xueyan, ZHANG Lifeng, GUI Manman, BAO Yingcun, DU Juan, PU Jianzhong, CHENG Weidong
Integrative Medicine Institute in School of Basic Medical Sciences of Lanzhou University, Lanzhou 730000, China
关键词:
细胞免疫; 免疫抑制; 玉屏风散; 复芪止汗颗粒
Keywords:
cellular immunity;  immunosuppression;  YuPingFengSan;  FuQiZ hiHan granules
分类号:
R285.5
文献标志码:
A
摘要:
目的：比较复方玉屏风散口服液和复芪止汗颗粒在提高免疫抑制小鼠细胞免疫功能方面的差异。方法：小鼠腹腔注射环磷酰胺制备免疫抑制模型，分别以生理盐水、玉屏风散口服液(6 g/kg?d)和复芪止汗颗粒(27 g/kg?d)灌胃，测定其胸腺和脾脏指数、T淋巴细胞增殖指数，T淋巴细胞亚群、INF-γ水平及腹腔巨噬细胞吞噬指数。结果：玉屏风散口服液和复芪止汗颗粒均能提高免疫抑制模型小鼠的胸腺和脾脏指数、T淋巴细胞增殖指数，CD3+、CD4+和CD8+淋巴细胞百分比及血清INF-γ水平，但两者之间比较差异具有统计学意义(P＜0.05)。结论：玉屏风散口服液和复芪止汗颗粒均能提高免疫抑制小鼠的细胞免疫功能，但玉屏风散口服液效果优于复芪止汗颗粒。
Abstract:
Objective: To compare the differences between compound YuPingFengSan oral liquid and FuQi ZhiHan granules in improving cellular immunity of mice with immunosuppression. Method: The models of immunosuppression mice were made through peritoneal injection of cyclophosphamide and then received gastric administration of physiological saline, YuPingFengSan oral liquid［6 g/(kg?d)］ and FuQi ZhiHan granules ［27 g/(kg?d］. Thymus and spleen index, proliferation index of T-lymphocyte, sub T-lymphocyte, the level of INF-γ and phagocytic indexes of peritoneal macrophages were tested. Result: Both of the drugs could improve thymus and spleen index, proliferation index of T-lymphocyte, lymphocytic percentages of CD3+, CD4+ and CD8+ as well as the level of serum INF-γ, the difference between both drugs had statistical meaning(P＜0.05). Conclusion: YuPingFengSan oral liquid and FuQi ZhiHan granules could improve cellular immunity of mice with immunosuppression, but clinical efficacy of YuPingSan oral liquid is better than FuQi ZhiHan granules.

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备注/Memo

备注/Memo:
收稿日期：2012-12-16 作者简介：李雪嫣(1986—)，女，硕士研究生。研究方向：中医药抗肿瘤。
更新日期/Last Update: 2013-08-15