[1]赵萍.消肿止痛合剂对大鼠骨折愈合中VEGF表达的影响[J].西部中医药,2013,26(11):16-18.
　ZHAO Ping.Effects of XiaoZhong ZhiTong Mixture on VEGF Expressions of Rats in the Healing Course of Bone Fracture[J].Western Journal of Traditional Chinese Medicine,2013,26(11):16-18.
点击复制

消肿止痛合剂对大鼠骨折愈合中VEGF表达的影响
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年11期
页码:
16-18
栏目:
出版日期:
2013-11-15

文章信息/Info

Title:
Effects of XiaoZhong ZhiTong Mixture on VEGF Expressions of Rats in the Healing Course of Bone Fracture
文章编号:
1004-6852(2013)11-0016-03
作者:
赵萍
甘肃省中医院，甘肃 兰州 730050
Author(s):
ZHAO Ping
Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
关键词:
骨折; 血管内皮细胞生长因子; 消肿止痛合剂; 大鼠
Keywords:
bone fracture;  vascular endothelial growth factor;  XiaoZhong ZhiTong mixture;  rat
分类号:
R683
文献标志码:
A
摘要:
目的：探讨大鼠骨折修复过程中骨痂组织中血管内皮细胞生长因子(VEGF)表达的变化及消肿止痛合剂对其的影响。方法：取5～6周龄SD大鼠30只，制作股骨中段闭合骨折模型，随机分为实验组和对照组各15只，实验组每12小时予消肿止痛合剂16 mL/(kg·d)，对照组不予药物治疗。分别在骨折后第2、4、7、10、21天每组各处死3只大鼠，取骨折周围软组织及骨痂，观察骨折部位骨痂形成情况，通过组织切片免疫组织化学染色，观察骨折修复中不同时期软骨细胞变化及骨痂中VEGF的表达。结果：VEGF的表达在2组动物骨折后第4天开始出现差异，第10天差异最大，第21天差异缩小，实验组中VEGF的表达信号强于对照组。结论：骨折愈合过程中软骨及骨性骨痂中均有VEGF表达，表明VEGF参与骨折愈合，消肿止痛合剂能提高VEGF的表达，利于骨折修复。
Abstract:
Objective: To explore the changes of vascular endothelial growth factor (VEGF) expressions in the callus during the healing course of bone fracture and the effects of XiaoZhong ZhiTong mixture on VEGF expressions of rats. Method: All 30 SD rats were chosen to establish the models, they were randomized into the experiment group and the control group equally, the experiment group took XiaoZhong ZhiTong mixture every 12 hours in the dose of 16 mL/( kg·d) and the control group were given with nothing. The rats were killed at the 2nd, 4th, 7th, 10th and 21st days respectively after fractured, soft tissue and callus around the location of bone fracture were taken to observe the formation of the callus. Changes of cartilage cells in different stages and VEGF expression in the callus were observed in the healing course of bone fracture by immunohistochemistry. Result: The difference appeared between both groups in VEGF expression at the 4th day, the difference was the most significant at the 10th day, it reduced at the 21st day. VEGF expressions in the experiment group was more than that of the control group. Conclusion: VEGF expressions occur in the cartilage and the callus in the healing course of bone fracture, which demonstrates the participation of VEGF in the healing course of bone fracture, XiaoZhong ZhiTong mixture could improve VEGF expression and is helpful to the healing of bone fracture.

相似文献/References:

[1]辛仲斌.手法复位低温板材塑形固定治疗第一掌骨基底部骨折45例[J].西部中医药,2013,26(08):86.
　XIN Zhongbin.Manipulative Reduction and Fixation with Low-temperature Thermoplastic Splint in Treating 45 Cases of Bone Fracture at the Base of the First Metacarpal[J].Western Journal of Traditional Chinese Medicine,2013,26(11):86.
[2]徐斌,张华.过伸复位手法在胸腰段骨折内固定术中的应用[J].西部中医药,2012,25(05):66.
　XU Bin,ZHANG Hua.Application of Hyper-extensive Reduction to Internal Fixation of Thoracolumbar Fracture[J].Western Journal of Traditional Chinese Medicine,2012,25(11):66.
[3]王浩,李晓飞,何宁,等.中西结合治疗肱骨髁上骨折32例[J].西部中医药,2015,28(08):119.
[4]王燕,石来军△.辨证施护在小儿骨折中的临床应用[J].西部中医药,2015,28(08):162.
[5]刘福善,胡永红,李维洁,等.中医康复对多发肋骨骨折纯钛爪形接骨板内固定术疗效的影响[J].西部中医药,2013,26(06):73.
　LIU Fushan,HU Yonghong,LI Weijie,et al.Effects of Rehabilitation Therapy in the Treatment for Multiple Fractured Ribs Based on Internal Fixation with Claw Plate of Pure Titanium[J].Western Journal of Traditional Chinese Medicine,2013,26(11):73.
[6]王彦斐,王彩文,白会玲.中医护理在骨折术后临床护理中的应用[J].西部中医药,2013,26(06):115.
　WANG Yanfei,WANG Caiwen,BAI Huiling.Application of TCM Nursing to the Patients Undergoing the Surgery of Bone Fracture[J].Western Journal of Traditional Chinese Medicine,2013,26(11):115.
[7]杨萍,尹小慧,陆立芳.骨伤科创伤性疾病术后用七叶皂苷钠治疗的临床护理[J].西部中医药,2012,25(09):108.
　YANG Ping,YIN Xiao-hui,LU Li-fang.Clinical Nursing for Postoperative Patients Suffering from Traumatic Disease of Orthopedics and Traumatology Department Treated with Soditum Aescinate for Injection[J].Western Journal of Traditional Chinese Medicine,2012,25(11):108.
[8]李盛华,张绍文,樊成虎.1 005例胸腰椎骨折住院患者流行病学特征分析[J].西部中医药,2014,27(05):70.
　LI Shenghua,ZHANG Shaowen,FAN Chenghu.Analysis on Epidemiological Features of 1 005 Inpatients with Thoracolumbar Fracture[J].Western Journal of Traditional Chinese Medicine,2014,27(11):70.
[9]郭景仲,王桂丽,指导：郭宪章.手法复位及小夹板固定治疗肱骨外髁翻转移位骨折33例临床观察[J].西部中医药,2013,26(05):93.
　GUO jingzhong,WANG Guili,Director: GUO Xianzhang.Clinical Observation on Manipulative Reduction and Small Splint Immobilization in Treating 33 Cases of Tumbling Displaced Fracture of External Condyle of Humerus[J].Western Journal of Traditional Chinese Medicine,2013,26(11):93.
[10]张绍文,李盛华,樊成虎.中西医结合保守治疗胸腰椎骨折470例临床疗效观察[J].西部中医药,2013,26(05):108.
　ZHANG Shaowen,LI Shenghua,et al.Curative Effects of Conservative Integrative Treatment for 470 Patients suffering from Thoracolumbar Fractures[J].Western Journal of Traditional Chinese Medicine,2013,26(11):108.

备注/Memo

备注/Memo:
收稿日期：2013-02-25 作者简介：赵萍(1977—)，女，硕士学位，主治医师。研究方向：手足外科疾病的微创治疗。
更新日期/Last Update: 2013-11-15