[1]王玉珠,王曌滢.止痒油膏外敷止痒作用的实验研究*[J].西部中医药,2013,26(12):15-16.
　WANG Yuzhu,WANG Zhaoying.Experimental Study on Relieving Itching of ZhiYang Ointment for External Use[J].Western Journal of Traditional Chinese Medicine,2013,26(12):15-16.
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止痒油膏外敷止痒作用的实验研究*
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年12期
页码:
15-16
栏目:
出版日期:
2013-12-15

文章信息/Info

Title:
Experimental Study on Relieving Itching of ZhiYang Ointment for External Use
文章编号:
1004-6852(2013)12-0015-02
作者:
王玉珠1，王曌滢2
1 甘肃省中医院，甘肃 兰州 730050； 2 甘肃中医学院
Author(s):
WANG Yuzhu1, WANG Zhaoying2
1 Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China; 2 Gansu University of Traditional Chinese Medicine
关键词:
瘙痒; 止痒油膏; 小鼠; 大鼠
Keywords:
pruritus;  ZhiYang ointment;  mice;  rat
分类号:
R285.5
文献标志码:
A
摘要:
目的：研究止痒油膏外敷的止痒作用。方法：用磷酸组胺致大鼠瘙痒模型,右旋糖酐致小鼠瘙痒模型，并设醋酸曲安奈德尿素软膏阳性对照组和蒸馏水阴性对照组，观察止痒油膏低剂量(50 mg/mL)、中剂量(100 mg/mL)、高剂量(200 mg/mL)，对实验动物局部皮肤瘙痒的影响。结果：止痒油膏能明显降低右旋糖酐诱导的小鼠瘙痒发作次数，增加大鼠耐受磷酸组胺的致痒阈。结论：止痒油膏外敷具有明显的止痒作用。
Abstract:
Objective: To investigate relieving itching of ZhiYang ointment for external use. Method: Rat model was established with histamine phosphate and mouse with dextran, positive control group of triamcinolone acetonide acetate and urea ointment as well as negative control group of distilled water were found, the effects of high (200 mg/mL), moderate(100 mg/mL) and low (50 mg/mL) dosages of ZhiYang ointment on local skin pruritus of animals were observed. Result: ZhiYang ointment could significantly reduce the number of mouse pruritus caused by dextran and increase itching threshold of the rat tolerance to histamine phosphate. Conclusion: ZhiYang ointment for external use could alleviate the itching obviously.

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[2]孙洁慧,赵景文,左 进. IL-1β，IL-8在使用复方苦参洗剂治疗小鼠瘙痒症中的表达[J].西部中医药,2012,25(10):18.
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备注/Memo

备注/Memo:
收稿日期：2013-06-30。*基金项目：甘肃省科技厅科学事业费科研项目（编号QS022-C33-042）。作者简介：王玉珠(1964—)，女，主任医师。研究方向：老年疾病的中医诊治。
更新日期/Last Update: 2013-12-15