[1]张娟,卿德刚,孙宇,等.复方大枣片增强免疫功能的实验研究*[J].西部中医药,2014,27(03):28-31.
 ZHANG Juan,QING Degang,SUN Yu,et al.Experimental Study on Compound Jujube Tablets in Improving Immunity[J].Western Journal of Traditional Chinese Medicine,2014,27(03):28-31.
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复方大枣片增强免疫功能的实验研究*
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
27
期数:
2014年03期
页码:
28-31
栏目:
方药·药理研究
出版日期:
2014-03-15

文章信息/Info

Title:
Experimental Study on Compound Jujube Tablets in Improving Immunity
文章编号:
1004-6852(2014)03-0028-04
作者:
张娟卿德刚孙宇倪慧△贾晓光
新疆维吾尔自治区中药民族药研究所,新疆 乌鲁木齐 830002
Author(s):
ZHANG Juan QING Degang SUN Yu NI Hui△ JIA Xiaoguang
Herb and Ethnic Drugs Institute of Xinjiang Uygur Autonomous Region, Urumqi 830002, China
关键词:
大枣复方制剂增强免疫力小鼠
Keywords:
jujube compound preparation improve immunity mice
分类号:
R285.5
文献标志码:
A
摘要:
目的:探讨复方大枣片对小鼠免疫力的影响。方法:将SPF级昆明种雌性小鼠200只随机分为5个实验组,每个实验组再随机分为低、中、高剂量[0.167、0.333、1.000 g/(kg·bw)]组及对照组4组,连续给药30天,分别进行迟发型变态反应实验、淋巴细胞转化实验,并检测抗体生成细胞、测定血清溶血素;同时进行小鼠碳廓清实验、小鼠腹腔巨噬细胞吞噬鸡红细胞实验、NK细胞活性实验,测定相关免疫学指标。结果:1.000 g/(kg·bw)剂量组能增加小鼠迟发型变态反应能力、淋巴细胞转化能力、抗体生成细胞数、血清半数溶血值,与对照组比较差异有统计学意义(P<0.05);0.333、1.000 g/(kg·bw)剂量组能增加小鼠NK细胞活性,与对照组比较差异具有统计学意义(P<0.05);3个剂量组对小鼠体质量、脾脏/体质量比值、胸腺/体质量比值、小鼠单核-巨噬细胞碳廓清能力、腹腔巨噬细胞吞噬鸡红细胞能力均无明显影响(P>0.05)。结论:复方大枣片具有增强小鼠免疫功能的作用。
Abstract:
Objective: To investigate the influence of compound jujube tablets on the immunity of the mice. Methods: All 200 mice were randomized into five experimental groups, and each group divided into low, moderate and high dosage groups[0.167, 0.333, 1.000 g/(kg·bw)] and the control group, for 30 consecutive days, the contents of antibody-producing cells (APC) and serum hemolysin were measured by delayed allergic reaction and lymphocyte transformation test respectively; associated immune indexes were detected by mice carbon clearance capacity test, mice peritoneal macrophage to swallow chicken red blood cells and the activity of NK cells. Results: High dosage group at the concentrations of 1.000g/(kg·bw) could increase the ability of delayed allergic reaction and lymphocyte transformation, the numbers of APC and HC50, which showed significant difference compared with the control group (P<0.05); high and moderate dosage groups in the concentrations of 0.333 and 1.000g/(kg·bw) could enhance the activity of NK cells, the difference had statistical meaning compared with the control group(P<0.05); there was insignificant difference in mice weight, the ratio of spleen/body weight, the ratio of thymus glang/weight, mononuclear macrophage carbon clearance capacity and the ability of peritoneal macrophage to swallow chicken red blood cells among the treatment groups with different dosages(P>0.05). Conclusion: Compound jujube tablets could enhance the immunity of the mice.

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备注/Memo

备注/Memo:
收稿日期:2013-06-17*基金项目:乌鲁木齐市科技计划项目(编号Y121110023)作者简介:张娟(1983—),女,硕士学位,助理研究员。研究方向:天然药物的分析及制剂研究。△通讯作者:倪慧(1964—),女,硕士研究生导师,硕士学位,研究员。研究方向:天然药物的分析及制剂研究。
更新日期/Last Update: 2014-03-15