[1]赵成国,秦书芝,毛晶磊,等.瑶宝克癌灵胶囊抗肿瘤作用机制研究[J].西部中医药,2014,27(05):7-9.
 ZHAO Chengguo,QIN Shuzhi,MAO Jinglei,et al.Investigation on Anti-tumor Mechanism of YaoBao KeAiLing Capsules[J].Western Journal of Traditional Chinese Medicine,2014,27(05):7-9.
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瑶宝克癌灵胶囊抗肿瘤作用机制研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
27
期数:
2014年05期
页码:
7-9
栏目:
方药·药理研究
出版日期:
2014-05-15

文章信息/Info

Title:
Investigation on Anti-tumor Mechanism of YaoBao KeAiLing Capsules
文章编号:
1004-6852(2014)05-0007-03
作者:
赵成国1秦书芝1毛晶磊2吴丽艳1肖洪彬3△
1 吉林大学珠海学院,广东 珠海 519041; 2 大庆油田总医院; 3 黑龙江中医药大学
Author(s):
ZHAO Chengguo1 QIN Shuzhi1 MAO Jinglei2 WU Liyan1 XIAO Hongbin3△
1 Zhuhai College of Jilin University, Zhuhai 519041, China; 2 Daqing Oilfield General Hospital; 3 Heilongjiang University of Chinese Medicine
关键词:
瑶宝克癌灵胶囊IL-2IFN-γp53Bcl-2
Keywords:
YaoBao KeAiLing capsules IL-2 IFN-γ p53 Bcl-2
分类号:
R273.5
文献标志码:
A
摘要:
目的:从分子生物学角度探讨瑶宝克癌灵胶囊抗肿瘤的作用机理。方法:采用双抗体夹心ELISA法检测S180荷瘤小鼠外周血白细胞介素-2(IL-2)、γ-干扰素(IFN-γ)的含量;采用免疫组化法检测凋亡相关基因突变型p53和Bcl-2基因的表达。结果:瑶宝克癌灵胶囊可明显增加小鼠外周血IL-2、IFN-γ的含量,可抑制突变型基因p53和Bcl-2基因的表达。结论:瑶宝克癌灵胶囊抗肿瘤的作用机制可能与增强荷瘤小鼠免疫功能,抑制突变型基因p53和Bcl-2基因的表达有关。
Abstract:
Objective: To explore anti-tumor mechanism of YaoBao KeAiLing capsules with molecular biology. Methods: The contents of interleukin-2 (IL-2) and interferon-γ (IFN-γ) were detected with double antibody sandwich ELISA method; the expressions of Bcl-2 gene and p53 were measured by immunohistochemical method. Results: YaoBao KeAiLing capsules could increase the contents of IL-2 and IFN-γ in peripheral blood of mice, inhibit the expressions of p53 and Bcl-2. Conclusion: Anti-tumor mechanism of YaoBao KeAiLing capsules might be related to increasing the immunity of the mice, inhibiting the expressions of p53 and Bcl-2.

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备注/Memo

备注/Memo:
收稿日期:2013-10-10作者简介:赵成国(1978—),男,硕士研究生,讲师。研究方向:中药药理学研究。△通讯作者:肖洪彬(1957—),男,博士后合作导师,博士研究生导师,教授。研究方向:方剂配伍规律及方剂疗效客观化的研究。
更新日期/Last Update: 2014-05-15