防风感冒颗粒解热抗炎作用的药效学研究-《西部中医药》

文章信息/Info

Title:: Study on Relieving Fever and Anti-inflammatory Pharmacodynamics of FangFeng GanMao Granules

Author(s):: GUO Xiaoying1, MA Xinhuan2△; 1 Wuquan Tielu Xicun Street Community Health Service Center of Chengguan District, Lanzhou 73000, China; 2 Gansu Provincial Hospital of Traditional Chinese Medicine

Keywords:: FangFeng GanMao granules; relieving fever; anti-inflammatory effect

摘要:: 目的：探讨防风感冒颗粒的解热和抗炎作用。方法：采用脂多糖(LPS)致兔发热模型和干酵母致大鼠发热模型，观察防风感冒颗粒的解热作用；采用二甲苯致小鼠耳廓肿胀模型和蛋清致大鼠足趾肿胀模型，检测炎症组织中PGE2的含量，观察防风感冒颗粒的抗炎作用。结果：与空白对照组比较，防风感冒颗粒能显著降低LPS致兔发热模型和干酵母致大鼠发热模型的体温(P＜0.05)，能抑制二甲苯致小鼠耳廓肿胀和蛋清致大鼠足趾肿胀的炎症反应(P＜0.05)，并能减少炎症组织中PGE2的含量(P＜0.05)。结论：防风感冒颗粒具有良好的解热和抗炎作用。

Abstract:: Objective: To observe relieving fever and anti-inflammatory effects of FangFeng GanMao granules. Methods: The rabbit model with fever was established with lipopolysaccharide (LPS) and rat model suffering from fever by dried yeast, relieving fever of FangFeng GanMao granules was investigated; mice with ear swelling were caused by dimethylbenzene and rats with toe swelling by albumen, the contents of PGE2 were detected in the inflammatory tissue to observe anti-inflammatory effects of FangFeng GanMao granules. Results: Compared with blank control group, the granules could obviously decrease the temperature of rabbit model suffering from fever induced by LPS and rat with fever induced by dried yeast (P＜0.05), inhibit inflammatory reaction of mice with ear swelling induced by dimethylbenzene and rat with toe swelling caused by albumen (P＜0.05), and reduce the contents of PGE2 in the inflammatory tissue (P＜0.05). Conclusion: FangFeng GanMao granules possess better effects of relieving the fever and anti-inflammation.