[1]卢青云,李文波,王沛,等.α1、β2微球蛋白在原发性高血压早期肾损害中的临床意义[J].西部中医药,2014,27(07):125-127.
　LU Qingyun,LI Wenbo,WANG Pei,et al.Clinical Significances of α1-microglobulin and β2-microglbulin in Early Renal Injury of the Patients Suffering from Essential Hypertension[J].Western Journal of Traditional Chinese Medicine,2014,27(07):125-127.
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α1、β2微球蛋白在原发性高血压早期肾损害中的临床意义
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
27
期数:
2014年07期
页码:
125-127
栏目:
出版日期:
2014-07-15

文章信息/Info

Title:
Clinical Significances of α1-microglobulin and β2-microglbulin in Early Renal Injury of the Patients Suffering from Essential Hypertension
文章编号:
1004-6852(2014)07-0125-03
作者:
卢青云，李文波，王沛，刘媛
甘肃省第二人民医院检验科，甘肃 兰州 730000
Author(s):
LU Qingyun, LI Wenbo, WANG Pei, LIU Yuan
Gansu Provincial the Second People′s Hospital, Lanzhou 73000, China
关键词:
原发性高血压; α1微球蛋白; β2微球蛋白; 早期肾损伤
Keywords:
hypertension;  essential;  α1-microglobulin;  β2-microglbulin;  early renal injury
分类号:
R972.4
摘要:
目的：探讨联合检测血、尿α1微球蛋白（α1-MG）、β2微球蛋白（β2-MG）在原发性高血压 (EH)早期肾损害中的临床意义。方法：将55例原发性高血压患者按Ccr＜85 mL/min和85 mL/min＜Ccr＜110 mL/min分为A（26）、B（29）2个亚组 ，另选健康体检者60例作为正常对照组，用免疫比浊法测定血、尿α1、β2微球蛋白的含量。结果　：A组患者血、尿α1、β2微球蛋白含量均较对照组显著升高（P＜0.01）；B组患者血、尿β2微球蛋白与对照组比较无显著性差异(P＞0.05)，而血、尿α1微球蛋白与对照组比较有显著性差异(P＜0.05)；B组与A组比较血、尿α1、β2微球蛋白差异有统计学意义（P＜0.05）。结论：联合检测血、尿α1微球蛋白（α1-MG）、β2微球蛋白（β2-MG）能够较好地反映原发性高血压肾损伤的病情程度，对其早期诊断具有重要临床应用价值。
Abstract:
Objective: To explore clinical significance of detecting α1-microglobulin (α1-MG) and β2-microglbulin (β2-MG) in early renal injury of the patients with essential hypertension (EH). Methods: Fifty-five patients were divided into group A (26 cases) and group B (29 cases) according to Ccr<85 mL/min and 85 mL/min＜Ccr＜110 mL/min, another 60 cases were chosen as normal control group, the contents of α1-MG and β2-MG in the blood and urine were detected with immunoturbidimetry assay(ITM). Results: The contents of α1-MG and β2-MG in the blood and urine in group A were improved significantly compared with the control group (P＜0.01); the comparison had no significant difference in the contents of β2-MG in the blood and urine when group B was compared with the control group (P＞0.05), it had significant difference in the contents of α1-MG in the blood and urine when group B was compared with the control group(P＜0.05); the difference showed statistical meaning when group B was compared with group A in the contents of α1-MG and β2-MG in the blood and urine (P＜0.05). Conclusion: Combination detection of α1-MG and β2-MG in the blood and urine could reflect the degree of early renal injury of EH patients, and the detection shows important clinical value in early diagnosis.

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备注/Memo

备注/Memo:
收稿日期：2013-12-29作者简介：卢青云(1970—)，女，主管技师。研究方向：临床生物化学检验。
更新日期/Last Update: 2014-07-15