[1]魏丽娜,刘子燕,郝晋雍,等.胶囊内镜下非甾体类抗炎药相关性小肠损伤特点分析[J].西部中医药,2014,27(07):128-130.
　WEI Lina,LIU Ziyan,HAO Jinyong,et al.The Analysis on the Features of NSAIDs-related Small Intestine Injury under Capsule Endoscope[J].Western Journal of Traditional Chinese Medicine,2014,27(07):128-130.
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胶囊内镜下非甾体类抗炎药相关性小肠损伤特点分析
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
27
期数:
2014年07期
页码:
128-130
栏目:
出版日期:
2014-07-15

文章信息/Info

Title:
The Analysis on the Features of NSAIDs-related Small Intestine Injury under Capsule Endoscope
文章编号:
1004-6852(2014)07-0128-03
作者:
魏丽娜，刘子燕，郝晋雍，黄晓俊△
兰州大学第二医院消化科，甘肃 兰州 730030
Author(s):
WEI Lina, LIU Ziyan, HAO Jinyong, HUANG Xiaojun△
Gastroenterology Department of Lanzhou University the Second Hospital, Lanzhou 730030, China
关键词:
小肠损伤; 溃疡; 非甾体抗炎药; 胶囊内镜
Keywords:
small intestine injury;  ulcer;  NSAID;  capsule endoscope
分类号:
R574.15
摘要:
目的：分析非甾体抗炎药（NSAIDs）引起小肠损伤的胶囊内镜下特点。方法：将小肠损伤患者74例根据1周前是否服用NSAIDs分为观察组与对照组，比较2组胶囊内镜下的病变部位和性质差异。结果：观察组无症状为71.4%，高于对照组25.6%，差异具有统计学意义(P＜0.05)，对照组消化道出血、腹痛、腹泻均高于观察组，差异具有统计学意义(P＜0.05)；观察组胶囊内镜下检查出溃疡率为22.9%，高于对照组的15.4%，且具有统计学意义(P＜0.05)，对照组胶囊内镜下出血率、孤立溃疡率较观察组高，具有统计学意义(P＜0.05)，肠黏膜糜烂2组比较未见明显差异(P＞0.05)。结论：胶囊内镜下非甾体抗炎药的损伤主要为黏膜糜烂，其溃疡表现为直径＜1 cm溃疡，多发，为表浅性溃疡，较未服用药者溃疡表现有较大差别，故胶囊内镜的使用有利于鉴别及相关治疗，且检查前服用胃肠汤剂可有效减少胶囊滞留的发生，并有益于病变的检出。
Abstract:
Objective: To explore the features of non-steroid anti-inflammatory drugs (NSAIDs) induced small intestine injury under capsule endoscope. Methods: Seventy-four patients were allocated to the observation group and the control group in accordance with whether they take NSAIDs one week ago, the lesions and the property of both groups were compared under capsule endoscope. Results: Asymptomatic ratio of the observation group was 71.4%, higher than 25.6% of the control group, the difference showed statistical meaning (P＜0.05); the control group was higher than the observation group in the ratio of hemorrhage of digestive tract, abdominal pain, diarrhea, the difference indicated statistical meaning (P＜0.05); exam ulcer rate under capsule endoscope of the observation group was 22.9%, higher than 15.4% of the control group, the difference demonstrated statistical meaning (P＜0.05); the control group was higher than the observation group in bleeding rate under capsule endoscope and solitary ulcer rate, the difference presented statistical meaning (P＜0.05); there was no significant difference between both groups in intestinal mucosal erosion (P＞0.05). Conclusion: The injury of NSAIDs under capsule endoscope is mainly mucosal erosion, the ulcer is less than 1cm, multiple and superficial one, ulcer expresses significant difference compared with the patients who didn't take NSAIDs, which is helpful to differentiate the ulcer and the related treatment. Taking decoction before examination could effectively reduce capsule retention, and it is helpful to detect the lesions.

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备注/Memo

备注/Memo:
收稿日期：2013-12-09作者简介：魏丽娜(1979—)，女，主治医师。研究方向：胶囊内镜对小肠疾病及消化道早癌的诊断。△通讯作者：黄晓俊(1962—)，男，硕士学位，主任医师。研究方向：消化道相关疾病的内镜下治疗。
更新日期/Last Update: 2014-07-15