[1]郭菊梅,杨光,陈慧昱,等.红芪替换黄芪后益气养血汤对老龄鼠抗氧化损伤及抗免疫衰老作用的比较研究*[J].西部中医药,2014,27(08):7-10.
　GUO Jumei,YANG Guang,CHEN Huiyu,et al.Comparative Study between YiQi YangXue Tang and the One Replacing HuangQi by HongQi on Anti-oxidative Damage and Anti-aging of Senile Rats[J].Western Journal of Traditional Chinese Medicine,2014,27(08):7-10.
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红芪替换黄芪后益气养血汤对老龄鼠抗氧化损伤及抗免疫衰老作用的比较研究*
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
27
期数:
2014年08期
页码:
7-10
栏目:
出版日期:
2014-08-15

文章信息/Info

Title:
Comparative Study between YiQi YangXue Tang and the One Replacing HuangQi by HongQi on Anti-oxidative Damage and Anti-aging of Senile Rats
文章编号:
1004-6852(2014)08-0007-04
作者:
郭菊梅1，杨光2，陈慧昱3，王文潇2，程卫东2，4△
1 陇西县种子管理站，甘肃 陇西 748100； 2 兰州大学中西医结合研究所； 3 兰州大学免疫学研究所； 4 南方医科大学中医药学院
Author(s):
GUO Jumei1, YANG Guang2, CHEN Huiyu3, WANG Wenxiao2, CHENG Weidong2,4△
1 Longxi County Seed Control Station, Longxi 748100, China; 2 Institute of Integrative Medicine of Lanzhou University; 3 Institute of Immunology of Lanzhou University; 4 TCM Institute of Southern Medical University
关键词:
红芪; 黄芪; 益气养血汤; 老龄小鼠; 抗氧化损伤; 抗免疫衰老
Keywords:
HongQi;  HuangQi;  YiQi YangXue Tang;  senile rats;  anti-oxidative damage;  anti-aging
分类号:
R285
文献标志码:
A
摘要:
目的：评估含红芪和含黄芪益气养血汤对衰老小鼠体内抗氧化损伤及抗免疫衰老作用的效果及差异。方法：用相同剂量红芪替换益气养血汤中的黄芪，灌胃18个月龄老龄鼠。测定老龄小鼠脾脏、胸腺指数，检测老龄小鼠血清超氧化物歧化酶(SOD)活力、丙二醛(MDA)水平和血清IL-2含量。结果：含红芪和含黄芪的益气养血汤均可提高老龄小鼠脾脏和胸腺指数，在提高脾脏指数方面红芪作用优于黄芪。2种药物均可提高血清SOD活力，降低MDA水平，且二者作用无差异（P＞0.05）。含红芪和含黄芪的益气养血汤均可升高老龄小鼠血清IL-2含量且红芪作用优于黄芪（P＜0.05）。结论：含红芪和含黄芪的益气养血汤对老龄小鼠有一定的抗氧化损伤和抗免疫衰老效果，且红芪作用与黄芪作用相当。含红芪的益气养血汤在提高老龄小鼠脾脏指数，提高血清IL-2含量方面优于含黄芪益气养血汤。
Abstract:
Objective: To evaluate the effects and the differences between YiQi YangXue Tang containing HongQi (Hedysarum polybotrys Hand.-Mazz.) and the one containing HuangQi[Astragalus membranaceus (Fisch.) Bunge.] on anti-oxidative damage and anti-aging of senile rats. Methods: The same doses of HongQi were used to replace HuangQi in the prescription of YiQi YangXue Tang, the decoction was given to senile rats at the age of 18 months by lavage. Spleen and thymus indexes of senile rats were detected, the contents of serum IL-2, the level of MDA and the activity of SOD were also measured. Results: YiQi YangXue Tang containing HongQi or HuangQi could raise spleen and thymus indexes of senile rats, HongQi was superior to HuangQi in improving spleen index. Both drugs could improve the activity of SOD and decrease the level of MDA, and there was no difference between them (P＞0.05). The decoction containing HongQi or HuangQi could improve the contents of IL-2, HongQi was superior to HuangQi(P＜0.05). Conclusion: YiQi YangXue Tang containing HongQi or HuangQi shows the effects of anti-oxidative damage and anti-aging to senile rats in a certain degree, and HongQi is equivalent to HuangQi. The decoction containing HongQi is superior to the one containing HuangQi in improving spleen index and the content of IL-2 in the serum.

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备注/Memo

备注/Memo:
收稿日期：2014-04-15*基金项目：国家自然科学基金面上项目(编号81373806)，2012年省卫生厅中医药科研立项课题(编号GZK-2-12-43)，兰州大学中央高校基本科研业务费专项资金资助项目(编号lzujbky-2013-172)作者简介：郭菊梅(1968—)，女，高级农艺师。研究方向：中药材栽培及种子繁育。△通讯作者：程卫东(1963—)，男，博士研究生导师，教授。研究方向：中药资源开发利用。
更新日期/Last Update: 2014-08-15