[1]吕立勋,李唐棣,赵琳琳,等.自制三清降糖缓释片对糖尿病兔血糖、血脂及氧化应激的影响*[J].西部中医药,2014,27(09):13-15.
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自制三清降糖缓释片对糖尿病兔血糖、血脂及氧化应激的影响*
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
27
期数:
2014年09期
页码:
13-15
栏目:
方药·药理研究
出版日期:
2014-09-15

文章信息/Info

作者:
吕立勋1李唐棣1赵琳琳1赵利刚1吴范武2
1 河北联合大学药学院,河北 唐山 063000; 2 河北联合大学中医学院
关键词:
糖尿病血脂氧化应激三清降糖方缓释片
分类号:
R587.1
摘要:
目的:探讨自制三清降糖缓释片对糖尿病兔血糖、血脂及体内氧化应激水平的影响。方法:采用高脂高糖饮食喂养健康雄性家兔4周后,静脉注射链脲佐菌素制备糖尿病模型。将造模成功的家兔随机分为正常组、模型组、格列美脲组、三清降糖方汤剂、三清降糖缓释片组5组,灌胃给药4周后,生化法测血脂、血糖浓度;放免法测血清胰岛素,并计算胰岛素抵抗指数;双抗体夹心-ELISA法测肿瘤坏死因子-α(TNF-α);WST法测超氧化物歧化酶;比色法测丙二醛和谷胱甘肽。结果:糖尿病兔各给药组与用药前比较血糖、血脂及SOD值、血清胰岛素及其抵抗指数均有所下降(P<0.05),谷胱甘肽水平无变化(P>0.05);而MDA、TNF-α水平升高,各给药组比较无统计学差异(P>0.05)。结论:三清降糖缓释片对糖尿病兔具有降血糖、降脂作用,同时能减轻氧化应激改变。

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备注/Memo

备注/Memo:
*基金项目:2011年唐山市科技支撑项目(编号1113020112a)作者简介:吕立勋(1972—),女,硕士学位,副教授。研究方向:中药药效物质基础及其制剂。
更新日期/Last Update: 2014-09-15