[1]李明彦,刘召.三黄汤口服并灌肠治疗溃疡性结肠炎临床观察[J].西部中医药,2014,27(11):127-130.
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三黄汤口服并灌肠治疗溃疡性结肠炎临床观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
27
期数:
2014年11期
页码:
127-130
栏目:
报道·特色医疗
出版日期:
2014-11-15

文章信息/Info

作者:
李明彦刘召
白银市平川区水泉镇中心卫生院,甘肃 白银 730916
关键词:
溃疡性结肠炎三黄汤DNA酶1IL-10TNF-αIL-8
分类号:
R574.62
文献标志码:
B
摘要:
目的:观察三黄汤治疗溃疡性结肠炎(UC)的临床疗效及作用机制。方法:将UC患者80例随机分为治疗组和对照组各40例,治疗组予三黄汤治疗,水煎服,1剂/d,同时采用三黄汤煎剂保留灌汤,2次/d,对照组予柳氮磺吡啶片2.0 g/次,3次/d,连续治疗8周后观察2组患者临床疗效、主观症状,同时内窥镜检查恢复情况以及治疗前后DNA酶1、白介素10(IL-10)、超氧化物歧化酶(SOD)、一氧化氮(NO)、肿瘤坏死因子α(TNF-α)、白介素8(IL-8)的表达。结果:治疗后临床疗效、主观症状、病灶恢复治疗组明显优于对照组(P<0.05);DNA酶1、IL-10、SOD、NO水平明显上升,TNF-α、IL-8、ET含量明显下降,组间比较差异有统计学意义(P<0.05)。结论:三黄汤治疗UC疗效确切,能明显提高DNA酶1及IL-10、SOD、NO的表达,使TNF-α、IL-8、ET下调。

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备注/Memo

备注/Memo:
作者简介:李明彦(1971—),男,主治医师。研究方向:脾胃病的中医诊治。
更新日期/Last Update: 2014-11-15