[1]吉利,张艳.益气通脉饮对慢性心力衰竭大鼠心功能及血清TNF-α、IL-6、TGF-β1水平的影响[J].西部中医药,2015,28(05):25-27.
点击复制

益气通脉饮对慢性心力衰竭大鼠心功能及血清TNF-α、IL-6、TGF-β1水平的影响
分享到:

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
28
期数:
2015年05期
页码:
25-27
栏目:
方药·药理研究
出版日期:
2015-05-15

文章信息/Info

文章编号:
1004-6852(2015)05-0025-03
作者:
吉利张艳
辽宁中医药大学附属医院心内一科,辽宁 沈阳 110032
关键词:
心力衰竭心功能TNF-αIL-6TGF-β1益气通脉饮
分类号:
R285.5
文献标志码:
A
摘要:
目的:探讨益气通脉饮不同剂量给药对慢性心力衰竭(CHF)大鼠心功能以及血清TNF-α、IL-6、TGF-β1水平的影响。方法:将40只大鼠随机分为模型对照组、中药等效剂量组、中药大剂量组、西药对照组、正常对照组,每组8只。采用结扎大鼠左冠状动脉主干的方法复制急性心梗后心衰大鼠模型,造模成功后,中药等效剂量组与大剂量组分别按照5.4 g/kg(体质量)、16.2 g/kg(体质量)予益气通脉饮煎取液灌胃;西药对照组予科素亚混悬液,按4.5 mg/kg(体质量)灌胃,模型对照组与正常对照组以同体积生理盐水灌胃。1次/d,共8周。采用多普勒超声心动图机测定CHF大鼠的心功能,用放射免疫法检测大鼠血清中TNF-α、IL-6、TGF-β1的含量。结果:模型对照组ESV、LVEF、EDV、SV与正常对照组比较差异有统计学意义(P<0.05);与模型对照组比较,中药等效剂量组、西药对照组ESV、LVEF、EDV、SV有统计学差异(P<0.05);而中药大剂量组和西药对照组比较各项指标无明显差异(P>0.05),与正常对照组相比,模型对照组大鼠血清TNF-α、IL-6、TGF-β1水平显著增高(P<0.01);中药大剂量组、等效剂量组和西药对照组血清TNF-α、IL-6、TGF-β1水平均较模型对照组降低(P<0.05)。而中药大剂量组、等效剂量组和西药对照组之间血清TNF-α、IL-6、TGF-β1水平比较差异无统计学意义(P>0.05)。结论:益气通脉饮可改善CHF大鼠的心衰症状,降低血清中TNF-α、IL-6、TGF-β1水平,从而延缓慢性心力衰竭的发生和发展。

相似文献/References:

[1]孙国荣,景克荣,权亚喜.生脉注射液对慢性心衰患者心功能及其心率变异性的影响[J].西部中医药,2013,26(04):68.
 SUN Guorong,JING Kerong,QUAN Yaxi.The Influence of ShengMai Injection on Heart Function and Heart Rate Variability of Patients with Chronic Heart Failure[J].Western Journal of Traditional Chinese Medicine,2013,26(05):68.
[2]杨晓霞,丁延虹△,杨衍涛,等.参附注射液对慢性充血性心力衰竭患者血清BNP、CRP、TNF-α、IL-6水平的影响[J].西部中医药,2012,25(09):3.
 YANG Xiao-xia,DING Yan-hong,YANG Yan-tao,et al.Effect of ShenFu Injection on Levels of BNP, CRP, TNF-α and IL-6 in Serum of Patients with Chronic Congestive Heart Failure[J].Western Journal of Traditional Chinese Medicine,2012,25(05):3.
[3]宋吉法.ACEI、ARB联合参松养心胶囊治疗慢性心力衰竭42例疗效观察[J].西部中医药,2012,25(07):63.
 SONG Ji-fa.Observation on Clinical Effects of ACEI and ARB Combined with ShenSong YangXin Capsule in Treating 42 Cases of Congestive Heart Failure[J].Western Journal of Traditional Chinese Medicine,2012,25(05):63.
[4]赵晓新,刘丽萍.临床护理路径在慢性充血性心力衰竭患者健康教育中的应用效果评价[J].西部中医药,2013,26(08):117.
 ZHAO Xiaoxin,LIU Liping.Evaluation on Clinical Nursing Pathway Applied to Health Education of Patients with Chronic Congestive Heart Failure[J].Western Journal of Traditional Chinese Medicine,2013,26(05):117.
[5]李淑贞,杨晓晖,顾 宇,等.补阳还五汤预处理对MIRI兔的保护作用*[J].西部中医药,2014,27(03):19.
 LI Shuzhen,YANG Xiaohui,GU Yu,et al.Protection of MIRI Rabbits by BuYang HuanWuTang[J].Western Journal of Traditional Chinese Medicine,2014,27(05):19.
[6]王盛强.辨证论治慢性心力衰竭临床观察[J].西部中医药,2014,27(06):78.
 WANG Shengqiang.On Treating Chronic Heart Failure by Syndrome Differentiation and Treatment[J].Western Journal of Traditional Chinese Medicine,2014,27(05):78.
[7]贾国龙,邓强,张雪霞.参附注射液对老年膝关节置换术围术期循环稳定性的影响[J].西部中医药,2014,27(06):99.
 JIA Guolong,DENG Qiang,ZHANG Xuexia.Effects of ShenFu Injection on Hemodynamics of Senile Patients with Knee Replacement in Perioperative Period[J].Western Journal of Traditional Chinese Medicine,2014,27(05):99.
[8]刘冬梅,邹剑杰,罗晓敏,等.益阴助阳、活血通脉法治疗充血性心力衰竭临床观察[J].西部中医药,2014,27(07):62.
 LIU Dongmei,ZOU Jianjie,LUO Xiaomin,et al.Clinical Observation on Treating Congestive Heart Failure by the Method of Tonifying Yin-Yang, Activating Blood and Freeing Vessels[J].Western Journal of Traditional Chinese Medicine,2014,27(05):62.
[9]赵嘉晶,曹飞,岳瑶函,等.慢性心力衰竭患者 LDH 与血浆 BNP 及中医证型相关性研究[J].西部中医药,2014,27(09):78.
[10]顾志燕,王永.参麦联合环磷腺苷葡胺治疗冠心病心力衰竭临床观察[J].西部中医药,2014,27(11):112.
[11]陈力,李静,吴奇.丹参酮ⅡA磺酸钠联合阿托伐他汀钙对冠心病心力衰竭的影响[J].西部中医药,2019,32(02):103.
 CHEN Li,LI Jing,WU Qi.Effects of Sodium TanshinonⅡA Silate Joined with Atorvastatin on Coronary Heart Disease Heart Failure[J].Western Journal of Traditional Chinese Medicine,2019,32(05):103.
[12]许禄华,黄小靖,宋银枝,等.丹芪心脉散对气虚血瘀型冠心病慢性心衰患者心室重构的干预效果及机制探讨[J].西部中医药,2021,34(08):1.[doi:10.12174/j.issn.2096-9600.2021.08.01]
 XU Luhua,HUANG Xiaojing,SONG Yinzhi,et al.Discussion on the Mechanism and Intervention Effects of Danqi Xinmai Powder on Ventricular Remodeling in Patients with Coronary Heart Disease and Chronic Heart Failure of Qi Deficiency and Blood Stasis Pattern[J].Western Journal of Traditional Chinese Medicine,2021,34(05):1.[doi:10.12174/j.issn.2096-9600.2021.08.01]

备注/Memo

备注/Memo:
作者简介:吉利(1973—),女,博士学位,副教授。研究方向:心血管内科疾病的临床教学与科研。
更新日期/Last Update: 2015-05-15