[1]严亚锋,白海侠,史亚军.脑清通颗粒质量标准的研究[J].西部中医药,2016,29(02):23-26.
 YAN Yafeng,BAI Haixia,SHI Yajun.Study on Quality Standard of NaoQingTong Granules[J].Western Journal of Traditional Chinese Medicine,2016,29(02):23-26.
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脑清通颗粒质量标准的研究()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
29
期数:
2016年02期
页码:
23-26
栏目:
出版日期:
2016-02-15

文章信息/Info

Title:
Study on Quality Standard of NaoQingTong Granules
文章编号:
1004-6852(2016)02-0023-04
作者:
严亚锋白海侠史亚军
陕西中医药大学,陕西 咸阳 712046
Author(s):
YAN Yafeng, BAI Haixia, SHI Yajun
Shaanxi University of Chinese Medicine, Xianyang 712046, China
关键词:
脑清通颗粒芍药苷决明子川芎山楂水蛭
Keywords:
NaoQingTong granules peoniflorin JueMingZi ChuanXiong ShanZha ShuiZhi
分类号:
R283
文献标志码:
A
摘要:
目的:建立脑清通颗粒的质量标准。方法:采用薄层色谱法(TLC)法鉴别方中决明子、川芎、山楂和水蛭,采用高效液相色谱法(HPLC)法测定赤芍中芍药苷的含量。结果:决明子、川芎、山楂和水蛭TLC色谱斑点清晰,无干扰,芍药苷在0.021 6~0.194 4 mg/mL范围内线性关系良好(r=0.999 7),平均加样回收率为99.19%,RSD=1.13%。结论:所建立的薄层鉴别方法斑点清晰、专属性强、重现性好,含量测定方法分离度好、结果准确,可有效控制脑清通颗粒的质量。
Abstract:
Objective: To establish quality standard of NaoQingTong granules. Methods: JueMingZi (Semen Cassiae), ChuanXiong (Ligusticum chuanxiong Hort.), ShanZha(Crataegus pinnatifida Bunge)and ShuiZhi(Whitmania pigra Whitman) in the prescription were identified by TLC method, the contents of peoniflorin was determined in ChiShao by using HPLC method. Results: Chromatographic spots of JueMingZi, ChuanXiong, ShanZhan and ShuiZhi were clear, and the blank test showed no interference, peoniflorin demonstrated better linear relationship in the range between 0.021 6 and 0.194 4 mg/mL(r=0.9 99 7), average recovery rate was 99.19%, RSD=1.13%. Conclusion: The TLC method, showing clear spots, high specificity, reproducible, good separation and accurate, could be used for quality control of NaoQingTong granules.

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备注/Memo

备注/Memo:
*基金项目:陕西省教育厅自然科学基金项目(编号2013JK0831,14JK1195)。作者简介:严亚锋(1976—),男,硕士学位,讲师,工程师,执业药师。研究方向:老年病的中药防治。
更新日期/Last Update: 2016-02-15