[1]张林峰,于天源△,潘璠,等.推拿对坐骨神经损伤大鼠层黏连蛋白表达的影响[J].西部中医药,2016,29(05):12-17.
　ZHANG Linfeng,YU Tianyuan,PAN Fan,et al.The Effects of Massage on the Expression of Laminin of the Rats with Sciatic Nerve Injury[J].Western Journal of Traditional Chinese Medicine,2016,29(05):12-17.
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推拿对坐骨神经损伤大鼠层黏连蛋白表达的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
29
期数:
2016年05期
页码:
12-17
栏目:
出版日期:
2016-05-15

文章信息/Info

Title:
The Effects of Massage on the Expression of Laminin of the Rats with Sciatic Nerve Injury
文章编号:
1004-6852(2016)05-0012-06
作者:
张林峰，于天源△，潘璠，鲁梦倩，冼思彤，崔旻珍，姚斌彬，郭鑫，贾文端，陶艳红，马驰
北京中医药大学，北京 100029
Author(s):
ZHANG Linfeng, YU Tianyuan△, PAN Fan, LU Mengqian, XIAN Sitong, CUI Minzhen, YAO Binbin, GUO Xin, JIA Wenduan, TAO Yanhong, MA Chi
Beijing University of Chinese Medicine, Beijing 100029, China
关键词:
坐骨神经损伤; 层黏连蛋白; 推拿治疗; 机理研究
Keywords:
scatic nerve injury;  laminin;  massage;  mechanism study
分类号:
R244.1
文献标志码:
A
摘要:
目的：探讨推拿对坐骨神经损伤(SNI)大鼠运动功能及脊髓腹角、损伤点处层黏连蛋白(LN)表达的影响。方法：将SD大鼠48只随机分为正常组、假手术组、模型组、模型对照组、推拿组，造模采用坐骨神经损伤模型，以按摩推拿手法模拟仪进行手法干预，观察各组大鼠斜板实验评分及L3～5节段脊髓和患侧坐骨神经处LN的表达情况。结果：造模7天后，模型组大鼠的斜板实验评分与同期正常组比较差异有统计学意义(P＜0.01)；模型组LN在脊髓腹角和坐骨神经处的表达与同期正常组相比升高(P＜0.05)；LN在正常组、模型组中脊髓腹角的表达量较坐骨神经中的表达明显增高(P＜0.01)。在推拿治疗20次后，模型组、模型对照组、推拿组斜板实验评分与同期正常组相比有差异(P＜0.05)，推拿组斜板实验评分与同期模型组相比升高(P＜0.05)；同时，模型组、模型对照组、推拿组LN在脊髓腹角和坐骨神经处的表达均高于同期正常组(P＜0.01)，推拿组LN在脊髓腹角和坐骨神经损伤处的表达与同期模型组比较明显升高(P＜0.01)；LN在正常组、推拿组中脊髓腹角的表达量明显较坐骨神经中的表达高(P＜0.01)。结论：推拿可以上调周围神经损伤大鼠LN在脊髓腹角和坐骨神经处的表达，加快损伤神经的修复，改善SNI大鼠的运动功能。
Abstract:
Objective: To explore the influence of massage on the expressions of laminin (LN) in the damage point and cornu ventrale medullae spinalis, motor function of the rats with sciatic nerve injury (SCI). Methods: Forty-eight rats were randomized into the normal group, sham operation group, the model group, model control group and massage group, the rat model with SNI was prepared and intervened with massage manipulation simulator, LN expressions of sciatic nerve in the affected limb and L3~5 spinal cords, and the scores of inclined plate test were observed. Results: After the models were prepared in seven days, there was significant difference when the model group was compared with the normal group at the same period in the scores of inclined plate test (P＜0.01); LN expressions in cornu ventrale medullae spinalis and sciatic nerve in the model group raised compared with the normal group at the same period(P＜0.05); LN expressions in cornu ventrale medullae spinalis in the normal group and the model group improved notably compared with LN expressions in sciatic nerve obviously(P＜0.01). After massage for 20 times, there was the difference existed in the comparison of the scores of inclined plate test when the model group, model control group, massage group were compared with the normal group at the same period (P＜0.05), the scores of inclined plate test raised in the massage group compared with the model group (P＜0.05); at the same time, the model group, model control group and the massage group were higher than the normal group in LN expressions in cornu ventrale medullae spinalis and sciatic nerve(P＜0.01), LN expressions in cornu ventrale medullae spinalis and sciatic nerve in the massage group raised obviously compared with the model group at the same period (P＜0.01); LN expressions in cornu ventrale medullae spinalis were higher than LN expressions in sciatic nerve in the normal group and the massage group significantly (P＜0.01). Conclusion: Massage could up-regulate LN expressions in cornu ventrale medullae spinalis and sciatic nerve of the rats with peripheral nerve injury, speed up the recovery of damaged nerve and improve the motor function of SNI rats.

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备注/Memo

备注/Memo:
收稿日期：2015-06-24*基金项目：国家自然科学基金资助项目（编号81373759）； 博士点基金资助项目（编号20130013110016）；北京市自然基金资助项目（编号7142097）。作者简介：张林峰(1990—)，男，在读硕士研究生。研究方向：针灸推拿治疗周围神经损伤的机理研究。△通讯作者：于天源(1965—)，男，博士研究生导师，博士学位，教授，主任医师。研究方向：针灸推拿治疗周围神经损伤的机理研究。
更新日期/Last Update: 2016-05-15