[1]颜春鲁,李盛华△,刘永琦,等.敦煌医方小补肾汤对镉染毒大鼠骨和肾功能的影响[J].西部中医药,2017,30(01):11-14.
　YAN Chunlu,LI Shenghua,et al.The Influence of Dunhuang Prescription Xiao BuShen Tang on Bone and Renal Functions of the Rats Exposed to Cadmium[J].Western Journal of Traditional Chinese Medicine,2017,30(01):11-14.
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敦煌医方小补肾汤对镉染毒大鼠骨和肾功能的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年01期
页码:
11-14
栏目:
出版日期:
2017-01-15

文章信息/Info

Title:
The Influence of Dunhuang Prescription Xiao BuShen Tang on Bone and Renal Functions of the Rats Exposed to Cadmium
文章编号:
1004-6852(2017)01-0011-04
作者:
颜春鲁1，2' target="_blank" rel="external">2，李盛华3△，刘永琦1，2' target="_blank" rel="external">2，伍志伟1，苏韫1，薛娜1，李广强1，雒志义1，朱俊燚1
1 甘肃中医药大学,甘肃 兰州 730000； 2 敦煌医学与转化省部共建教育部重点实验室； 3 甘肃省中医院
Author(s):
YAN Chunlu1, 2' target="_blank" rel="external"> 2, LI Shenghua1△, LIU Yongqi1, 2' target="_blank" rel="external"> 2, WU Zhiwei, SU Yun1, XUE Na1, LI Guangqiang1, LUO Zhiyi1, ZHU Junyi1
1 Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China; 2 Key Laboratory for Transfer of Dunhuang Medicine at the Provincial and Ministerial Level; 3 Gansu Provincial Hospital of Traditional Chinese Medicine
关键词:
骨代谢; 肾损伤; 镉染毒; 小补肾汤
Keywords:
bone metabolism;  renal injury;  cadmium exposure;  Xiao BuShen Tang
分类号:
R917
文献标志码:
A
摘要:
目的：探讨敦煌医方小补肾汤对镉染毒大鼠骨和肾功能的影响。方法：将SPF级Wistar大鼠60只按体质量随机分为6组：空白组、乙酰半胱氨酸组、模型组及小补肾汤高、中、低剂量组。空白组腹腔注射0.9% NaCl，其余5组均腹腔注射0.1%氯化镉，1.5 mg/kg注射，相当于1.5 mL/kg，每周5次，共5周，进行染毒。染毒的同时，分别给予相应干预，乙酰半胱氨酸组组予乙酰半胱氨酸泡腾片溶液（5.4 mg/mL）1 mL/100 g，小补肾汤各剂量组予相应剂量（高：2.7 g/mL，中：1.35 g/mL，低：0.675 g/mL）小补肾汤1 mL/100 g灌胃治疗，每天1次，连续5周。最后1次注射后，取血检测。结果：与空白对照组比较，模型组大鼠血清钙、磷、骨钙素（OC）显著降低，2组比较差异有统计学意义（P＜0.05）；与模型组比较，乙酰半胱氨酸组、小补肾汤高中低剂量组大鼠血清钙、磷、OC显著增加，差异有统计学意义（P＜0.05）。与空白对照组比较，模型组大鼠血清碱性磷酸酶（ALP）、抗酒石酸酸性磷酸酶5b（TRACP-5b）、尿素氮（BUN）显著升高，2组比较差异有统计学意义（P＜0.05）；与模型组比较，乙酰半胱氨酸组、小补肾汤高中低剂量组大鼠血清ALP、TRACP-5b、BUN显著降低，差异有统计学意义（P＜0.05）。结论：小补肾汤对于镉染毒大鼠骨和肾功能具有一定的修复作用。
Abstract:
Objective: To discuss the effects of Dunhuang prescription Xiao BuShen Tang on bone and renal functions of the rats exposed to cadmium. Methods: Sixty rats were randomly divided into six groups: the blank group, acetylcysteine group, the model group, the groups of high, moderate and low dosages of Xiao BuShen Tang. The blank group accepted peritoneal injection of 0.9% NaCl, other groups were given intraperitoneal injection of 0.1% cadmium chloride, 1.5 mg/kg injection, equivalent to 1.5 mL/kg, five times each week, a total of five weeks. At the same time, they accepted corresponding intervention measures respectively, acetylcysteine group received acetylcysteine effervescent tablets solution (5.4 mg/mL) 1 mL / 100 g, different dosages groups of Xiao BuShen Tang accepted intragastric administration of different dosages (high: 2.7g/mL, moderate: 1.35g/mL and low: 0.675g/mL) of Xiao BuShen Tang in the density of 1mL/100g, once per day, for five weeks consecutively. The blood was tested after the last injection. Results: Compared with blank control group, the levels of serum calcium, phosphorus and osteocalcin (OC) of the model group decreased notably, the difference showed statistical meaning between both groups (P＜0.05); compared with the model group, the levels of serum calcium, phosphorus and OC increased in acetylcysteine group, high, moderate and low dosages groups of Xiao BuShen Tang significantly, and the difference showed statistical meaning (P＜0.05). Compared with blank control group, the levels of ALP, TRACP-5b and BUN elevated remarkably in the model group, and the difference had statistical meaning (P＜0.05); compared with the model group, the levels of ALP, TRACP-5b and BUN decreased remarkably in acetylcysteine group, high, moderate and low dosages groups of Xiao BuShen Tang, and the difference showed statistical meaning (P＜0.05). Conclusion: Xiao BuShen Tang could recover bone and renal functions of the rats suffering cadmium exposure to a certain degree.

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备注/Memo

备注/Memo:
收稿日期：2016-09-22 *基金项目：甘肃省自然科学基金项目(编号1508RJZA046)；甘肃中医药大学中青年基金项目(编号ZQ2014-9)；敦煌医学与转化省部共建教育部重点实验室开放基金项目(编号DHYX1213-004)。作者简介：颜春鲁（1979—），男，在读博士研究生，副教授。研究方向：骨伤疾病的中医药防治。 △通讯作者：李盛华(1959—)，男，教授，主任医师，博士研究生导师，享受国务院特殊津贴专家，卫生部突出贡献中青年专家，甘肃省优秀专家，甘肃省名中医，甘肃省领军人才第一层次，甘肃省“555”创新人才，甘肃省“333”科技人才，甘肃省卫生厅跨世纪学术技术带头人，甘肃省中医院首席主任医师，国家级重点学(专)科——骨科学科带头人。兼任中华中医药学会理事，中华中医药学会骨伤分会副主任委员，中国中西医结合学会骨科微创专业委员会主任委员，中国中西医结合学会脊柱医学专业委员会常务理事，甘肃省中医药学会副会长，甘肃省中西医结合学会副会长，甘肃省康复学会副会长，甘肃省中医药学会骨伤专业委员会主任委员，甘肃省中西医结合学会骨伤科专业委员会主任委员，《中国中医骨伤科》杂志副主编，《西部中医药》杂志编委会副主任，《中国骨伤》《中医正骨》杂志编委。陇中正骨学术流派传承工作室负责人。研究方向：骨与关节疾病的中西医结合治疗。
更新日期/Last Update: 2017-01-15