[1]刘书宇,叶沃若,潘 涛,等.同型半胱氨酸与冠心病中医辨证分型及冠脉病变程度的相关性[J].西部中医药,2017,30(11):88-91.
　LIU Shuyu,YE Woruo,PAN Tao,et al.The Relativity between Syndrome Differentiation, Patterns of Coronary Heart Disease, Coronary Artery Lesion and Homocysteine[J].Western Journal of Traditional Chinese Medicine,2017,30(11):88-91.
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同型半胱氨酸与冠心病中医辨证分型及冠脉病变程度的相关性()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年11期
页码:
88-91
栏目:
出版日期:
2017-11-15

文章信息/Info

Title:
The Relativity between Syndrome Differentiation, Patterns of Coronary Heart Disease, Coronary Artery Lesion and Homocysteine
文章编号:
1004-6852(2017)11-0088-04
作者:
刘书宇1，叶沃若2，3' target="_blank" rel="external">3，潘 涛2,3' target="_blank" rel="external">3，宫剑滨1△
1 南京军区南京总医院心脏内科，江苏 南京 210000； 2 江苏省中医院； 3 南京中医药大学第一临床医学院
Author(s):
LIU Shuyu1, YE Woruo 2，3' target="_blank" rel="external">3, PAN Tao2，3' target="_blank" rel="external">3, GONG Jianbin1△
1 Department of Cardiology, Nanjing General Hospital of Nanjing Command, Nanjing 210000, China; 2 Jiangsu Province Hospital of TCM; 3 The First Clinical Medical School, Nanjing University of Chinese Medicine
关键词:
冠心病; 中医辨证分型; 冠脉病变; 同型半胱氨酸
Keywords:
coronary heart disease;  syndrome differentiation and patterns;  coronary artery lesion;  homocysteine
分类号:
R541.14
摘要:
目的：探讨同型半胱氨酸与冠心病中医证型及冠脉病变程度的相关性。方法：将冠心病患者140例于冠状动脉造影检查前进行中医辨证分型，并行血同型半胱氨酸指标检测，分析同型半胱氨酸与冠心病中医辨证分型及冠脉病变程度的相关性。结果：冠脉单支病变组和多支病变组同型半胱氨酸水平与对照组相比明显增高(P＜0.05)，多支病变组较单支病变组增高(P＜0.05)。冠心病组同型半胱氨酸阳性率与对照组比较明显升高(P＜0.05)，多支病变组与单支病组同型半胱氨酸阳性率比较差异无统计学意义(P＞0.05)。冠心病组各证型同型半胱氨酸水平及其阳性率均高于对照组(P＜0.05)。冠心病组不同证型间，心血瘀阻组及痰浊内阻组同型半胱氨酸水平显著高于寒凝心脉组、心气虚弱组、心肾阴虚组及心肾阳虚组(P＜0.05)，心血瘀阻组与痰浊内阻组比较差异无统计学意义(P＞0.05)。冠心病组不同证型间，心血瘀阻，痰浊内阻、寒凝心脉及心气虚弱组同型半胱氨酸阳性率显著高于其他证型(P＜0.05)；心血瘀阻、痰浊内阻、寒凝心脉及心气虚弱组同型半胱氨酸阳性率比较差异无统计学意义(P＞0.05)。冠脉完全闭塞及重度狭窄组同型半胱氨酸水平高于中度狭窄(P＜0.05)。冠脉完全闭塞组同型半胱氨酸阳性率高于中度狭窄组(P＜0.05)。结论：同型半胱氨酸与冠心病中医证型之间存在相关性，可作为冠心病中医辨证分型的客观指标。同型半胱氨酸与冠脉病变程度存在相关性，同型半胱氨酸可用于预测冠状动脉粥样硬化的病变程度。
Abstract:
Objective: to explore the relativity between homocysteine and TCM patterns of coronary heart disease(CHD), as well as coronary artery lesion. Methods: Before the examination of coronary arteriongraphy (CAG), 140 CHD patients were differentiated and grouped, and performed the detection of blood homocysteine indexes, the relativity between homocysteine, TCM patterns of CHD and coronary artery lesion was analyzed. Results: The level of homocysteine in single coronary artery lesion group and multi-branch lesion group raised obviously compared with the control group (P＜0.05), it raised when multi-branch lesion group was compared with single coronary artery lesion group (P＜0.05). Compared with the control group, homocysteine positive rate in CHD group raised notably (P＜0.05), the difference had no statistical meaning when multi-branch lesion group was compared with single coronary artery lesion group in homocysteine positive rate(P＞0.05). CHD group in different patterns were higher than the control group in the level of homocysteine and the positive rate(P＜0.05). The comparisons among different patterns of CHD group, heart blood stasis group and internal block group of phlegm-turbidity group were higher than cold coagulating heart and vessel group, heart Qi deficiency group, heart-kidney Yin-deficiency group and heart-kidney Yang deficiency group in the levels of homocysteine notably(P＜0.05), the difference had no statistical meaning in the comparisons of heart blood stasis group and internal block group of phlegm-turbidity(P＞0.05). The comparisons among different patterns of CHD group, heart blood stasis group, internal block group of phlegm-turbidity, cold coagulating heart and vessel group and heart Qi deficiency group were higher than other patterns in homocysteine positive rate (P＜0.05); and the difference had no statistical meaning (P＞0.05). Coronary complete obstruction group and severe stenosis group were higher than moderate stenosis group in the levels of homocysteine (P＜0.05). Coronary complete obstruction group was higher than moderate stenosis in homocysteine positive rate (P＜0.05). Conclusion: Homocysteine shows the connection to TCM patterns of CHD, and it could be taken as the objective indexes of syndrome differentiation and paterns of CHD. Homocysteine is related to coronary artery lesion, and it could be used to predict pathological changes of coronary atherosclerosis.

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备注/Memo

备注/Memo:
收稿日期：2017-02-27 作者简介：刘书宇(1983—)，男，硕士学位，医师。研究方向：冠心病的中西医结合诊治。 △通讯作者：宫剑滨(1962—)，男，博士学位，主任医师。研究方向：心血管疾病的诊治。
更新日期/Last Update: 2017-11-15