[1]宋红霞,薛晓东△.消银汤对银屑病样模型小鼠TNF-α及IL-10的影响[J].西部中医药,2018,31(01):16-18.
 SONG Hongxia,XUE Xiaodong.Effects of XiaoYin Decoction on IL-10 and TNF-α of Psoriasis like Mice Model[J].Western Journal of Traditional Chinese Medicine,2018,31(01):16-18.
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消银汤对银屑病样模型小鼠TNF-α及IL-10的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年01期
页码:
16-18
栏目:
出版日期:
2018-01-07

文章信息/Info

Title:
Effects of XiaoYin Decoction on IL-10 and TNF-α of Psoriasis like Mice Model
文章编号:
1004-6852(2018)01-0016-03
作者:
宋红霞1薛晓东2△
1 重庆三峡医药高等专科学校药理教研室,重庆 万州 404000; 2 重庆三峡医药高等专科学校附属医院皮肤科
Author(s):
SONG Hongxia1, XUE Xiaodong2△
1 Department of Pharmacology, Chongqing Three Gorges Medical College, Wanzhou 404000, China; 2 Department of Dermatology, Affiliated Hospital to Chongqing Three Gorges Medical College
关键词:
银屑病肿瘤坏死因子α白细胞介素10消银汤
Keywords:
psoriasis TNF-α IL-10 XiaoYin decoction
分类号:
R285.5
文献标志码:
A
摘要:
目的:观察消银汤对银屑病样模型小鼠肿瘤坏死因子α(TNF-α)及白细胞介素10(IL-10)的作用。方法:建立小鼠阴道上皮模型,给予不同剂量的消银汤干预,14天后采用酶联免疫吸附法(ELISA)检测小鼠血清TNF-α、IL-10的含量,并观察消银汤对小鼠阴道上皮细胞有丝分裂的影响。结果:消银汤高、中、低剂量组均可明显抑制小鼠阴道上皮的有丝分裂(P<0.01),高、中剂量均可明显降低小鼠血清中TNF-α的水平(P<0.01),升高IL-10的水平(P<0.05或P<0.01)。结论:消银汤对银屑病样小鼠的治疗作用可能与其抑制表皮细胞增殖并降低血清中TNF-α的水平,升高IL-10的水平有关。
Abstract:
Objective: To observe the effects of XiaoYin decoction on TNF-α and IL-10 of psoriasis like mice model. Methods: Mice model with vaginal epithelium was established and intervened with different doses of XiaoYin decoction, the contents of TNF-α and IL-10 in the serum of the mice were detected by using ELISA method in 14 days, and the effects of XiaoYin decoction on the mitosis of mice vaginal epithelial cells were observed. Results: XiaoYin decoction in high, moderate and low dose could obviously inhibit the mitosis of mice vaginal epithelial cells (P<0.01), high and moderate doses could notable decrease the level of TNF-α in the serum of the mice (P<0.01), raise the levels of IL-10 (P<0.05 or P<0.01). Conclusion: Therapeutic effects of XiaoYin decoction for the mice with psoriasis might be related to inhibiting the proliferation of epidermal cell, decreasing the level of TNF-α and raising the levels of IL-10.

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备注/Memo

备注/Memo:
收稿日期:2017-06-05 *基金项目:重庆市万州区科技计划项目(编号201303042)。 作者简介:宋红霞(1981—),女,硕士学位,副教授。研究方向:皮肤病的基础研究。 △通讯作者:薛晓东(1981—),男,硕士学位,主治医师。研究方向:皮肤病的中医药治疗。
更新日期/Last Update: 2018-01-15