[1]薛晓东,宋红霞△.消银汤联合NB-UVB对寻常型银屑病血热证疗效及血清中Th1/Th2型细胞因子的影响[J].西部中医药,2018,31(01):86-88.
　XUE Xiaodong,SONG Hongxia.Clinical Effects of XiaoYin Decoction Combined with NB-UVB in Treating Psoriasis Vulgaris of Blood-heat Pattern and the Influence on Th1/Th2 Cytokine in the Serum[J].Western Journal of Traditional Chinese Medicine,2018,31(01):86-88.
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消银汤联合NB-UVB对寻常型银屑病血热证疗效及血清中Th1/Th2型细胞因子的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年01期
页码:
86-88
栏目:
出版日期:
2018-01-07

文章信息/Info

Title:
Clinical Effects of XiaoYin Decoction Combined with NB-UVB in Treating Psoriasis Vulgaris of Blood-heat Pattern and the Influence on Th1/Th2 Cytokine in the Serum
文章编号:
1004-6852(2018)01-0086-03
作者:
薛晓东1，宋红霞2△
1 重庆三峡医药高等专科学校附属医院皮肤科，重庆 万州404000； 2 重庆三峡医药高等专科学校药理教研室
Author(s):
XUE Xiaodong1, SONG Hongxia2△
1 Department of Dermatology, Affiliated Hospital, Chongqing Three Gorges Medical College, Wanzhou 404000, China; 2 Pharmacological Staff Room, Chongqing Three Gorges Medical College
关键词:
银屑病; NB-UVB; Th1/Th2型细胞因子; 消银汤
Keywords:
psoriasis vulgaris;  NB-UVB;  Th1/Th2 cytokine;  XiaoYin decoction
分类号:
R268
文献标志码:
B
摘要:
目的：观察消银汤联合窄谱中波紫外线(NB-UVB)治疗寻常型银屑病血热证的疗效及对患者血清Th1/Th2型细胞因子表达的影响。方法：将寻常型银屑病血热证患者60例随机分为治疗组及对照组，每组30例，治疗组予消银汤联合NB-UVB照射治疗，对照组予NB-UVB照射治疗，8周后评价疗效并测定2组患者治疗前后血清Th1/Th2型细胞因子［干扰素γ(IFN-γ)、白细胞介素2(IL-2)、白细胞介素4(IL-4)、白细胞介素10(IL-10)］水平。结果：治疗组临床疗效优于对照组(P＜0.05)；治疗组治疗后PASI评分明显低于对照组(P＜0.01)；治疗组IFN-γ、IL-2、IL-4、IL-10及对照组IFN-γ、IL-2与治疗前比较，差异均有统计学意义(P＜0.01)；2组治疗后各指标比较，差异均有统计学意义(P＜0.01)。结论：消银汤联合NB-UVB治疗寻常型银屑病血热证疗效确切，可能与调节Th1/Th2型细胞因子水平有关。
Abstract:
Objective: To observe clinical effects of XiaoYin decoction combined with NB-UVB in the treatment for psoriasis vulgaris of blood-heat pattern and its influence on the expressions of Th1/Th2 cytokine. Methods: Sixty patients were randomly divided into the treatment group and the control group, 30 cases each group, the patients in the treatment group were treated by XiaoYin decoction combined with NB-UVB and the ones in the control group were radiated by NB-UVB, the levels of Th1/Th2 cytokines (IFN-γ, IL-2, IL-4 and IL-10) in the serum of both groups were assessed before and after treating, and the effects were assessed in eight weeks. Results: The treatment group was superior to the control group in clinical effects (P＜0.05); the treatment group was lower than the control group in PASI scales after treating obviously (P＜0.01); the differences had statistical meaning in the comparisons of IFN-γ, IL-2, IL-4 and IL-10 of the treatment group before and after treating, and IFN-γ and IL-2 of the control group (P＜0.01); The difference was statistically significant when the indexes of the treatment group were compared with these of the control group after treating (P＜0.01). Conclusion: XiaoYin decoction combined with NB-UVB could obtain definite effects in the treatment for psoriasis vulgaris of blood-heat pattern, which might be related to regulating the levels of Th1/Th2 cytokine.

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备注/Memo

备注/Memo:
收稿日期：2017-04-27 *基金项目：重庆市万州区科技计划项目(编号201303042)。 作者简介：薛晓东(1981—)，男，硕士学位，主治医师。研究方向：皮肤病的中医药治疗。 △通讯作者：宋红霞(1981—)，女，硕士学位，副教授。研究方向：皮肤病的基础研究。
更新日期/Last Update: 2018-01-15