[1]张耕源,张建春,谢娜,等.舒肝解郁胶囊对围绝经期失眠妇女血清FSH、IL-1β及5-HT的影响[J].西部中医药,2018,31(04):5-9.
　ZHANG Gengyuan,ZHANG Jianchun,XIE Na,et al.Effects of Liver-soothing Depression-relieving Capsules on FSH, IL-1β and 5-HT in the Serum of Female Patients with Menopausal Insomnia[J].Western Journal of Traditional Chinese Medicine,2018,31(04):5-9.
点击复制

舒肝解郁胶囊对围绝经期失眠妇女血清FSH、IL-1β及5-HT的影响()
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年04期
页码:
5-9
栏目:
出版日期:
2018-04-15

文章信息/Info

Title:
Effects of Liver-soothing Depression-relieving Capsules on FSH, IL-1β and 5-HT in the Serum of Female Patients with Menopausal Insomnia
文章编号:
1004-6852(2018)04-0005-05
作者:
张耕源1，张建春2，谢娜3，孙亚平3，王彩娟4△
1 易县医院，河北 保定 071000； 2 华北理工大学； 3 河北省定州市中医医院； 4 石家庄市中医院
Author(s):
ZHANG Gengyuan1, ZHANG Jianchun2, XIE Na3, SUN Yaping3, WANG Caijuan4△
1 Yixian County Hospital, Baoding 071000, China; 2 North China University of Science and Technology; 3 Dingzhou Municipality TCM Hospital; 4 Shijiazhuang Municipality TCM Hospital
关键词:
围绝经期失眠; 舒肝解郁胶囊; 促卵泡激素; 白介素1β; 5-羟色胺
Keywords:
menopausal insomnia;  liver-soothing depression-relieving capsules;  FSH;  IL-1β;  5-HT
分类号:
R271.11+6
文献标志码:
A
摘要:
目的：探讨舒肝解郁胶囊对更年期失眠妇女血清促卵泡激素(FSH)、白介素1β(IL-1β)及5-羟色胺(5-HT)的影响。方法：将76例肝郁型围绝经期失眠女性，按1∶1比例随机分为对照组、观察组，每组38例。对照组予艾司唑仑、谷维素治疗，观察组予舒肝解郁胶囊治疗。检测2组血清性激素、细胞因子及单胺类神经递质水平，应用多导睡眠图(PSG)评价睡眠质量，比较临床效果。结果：与治疗前比较，对照组促卵泡激素(FSH)、黄体生成素(LH)、雌二醇(E2)无变化，差异无统计学意义(P＞0.05)，观察组FSH、LH明显降低(P＜0.01)，E2升高(P＜0.01)；2组IL-1β、肿瘤坏死因子α(TNF-α)、5-HT、β-内啡肽(β-EP)均升高(P＜0.01)，5-羟吲哚乙酸(5-HIAA)降低(P＜0.01)，睡眠潜伏期(SL)、觉醒次数(AT)、觉醒时间(AWT)、REW睡眠潜伏期(RL)降低(P＜0.01)，睡眠效率(SE)升高(P＜0.01)，S1降低(P＜0.01)，S2、S3+S4、快波睡眠(REM)升高(P＜0.01)。与对照组比较，观察组FSH、LH较低(P＜0.01)，E2较高(P＜0.01)，IL-1β、TNF-α较高(P＜0.01)，5-HT、β-EP较高(P＜0.01)，5-HIAA较低(P＜0.01)，SL、AT、AWT、RL均较低(P＜0.01)，SE较高(P＜0.01)，S1较低(P＜0.01)，S2、S3+S4、REM较高(P＜0.01)，总有效率较高(P＜0.05)。结论：中药舒肝解郁胶囊通过调节FSH、IL-1β、5-HT等机制，从而改善更年期失眠女性睡眠质量。
Abstract:
Objective: To discuss the effects of liver-soothing depression-relieving capsules on follicle stimulating hormone (FSH), interleukin-1β (IL-1β) and 5-hydroxytryptamine (5-HT) in the serum of female with menopausal insomnia. Methods: All 76 patients suffering menopausal insomnia of liver depression pattern were separated into the control group and the observation group randomly according to the ratio of 1∶1, 38 cases each group. The patients in the control group were given estazolam and oryzanol, and the ones in the observation group liver-soothing depression-relieving capsules. The levels of sex hormone, cytokines and monoamine neurotransmitter were detected, clinical effects were compared and sleep quality was assessed by using polysomnogram (PSG). Results: Compared with before treating, FSH, luteinizing hormone (LH), estradiol (E2) in the control group showed no change，and the difference had no statistical meaning (P＞0.05), the levels of FSH and LH in the observation group lowered notably (P＜0.01), E2 rose (P＜0.01); the levels of IL-1β, TNF-α, 5-HT and β-endorphin (β-EP) in both groups raised(P＜0.01),5-hydroxyindoleacetic acid (5-HIAA) decreased (P＜0.01), sleep latency (SL), awakening times (AT), awakening time (AWT), REM sleep latency (RL) lowered (P＜0.01), sleep efficiency (SE) lifted (P＜0.01), S1 decreased (P＜0.01),S2, S3+S4 and REM evaluated (P＜0.01). Compared with the control group, the levels of FSH and LH were lower in the observation group (P＜0.01), E2 raised (P＜0.01), the levels of IL-1β and TNF-α were higher (P＜0.01), the levels of 5-HT and β-EP were higher (P＜0.01), the level of 5-HIAA was lower (P＜0.01), SL, AT, AWT and RL were lower (P＜0.01), SE was higher (P＜0.01), S1 was lower (P＜0.01), S2, S3+S4 and REM were higher (P＜0.01), total effective rate was higher (P＜0.05). Conclusion: Liver-soothing depression-relieving capsules could improve sleep quality of female with menopausal insomnia by regulating FSH, IL-1β, 5-HT and others.

备注/Memo

备注/Memo:
收稿日期：2017-10-10 *基金项目：河北省自然科学基金项目(编号303453)。 作者简介：张耕源(1980—)，女，主治医师。研究方向：妇产科疾病的临床诊治。 △通讯作者：王彩娟(1978—)，女，副主任医师。研究方向：脑血管病的临床诊治。
更新日期/Last Update: 2018-04-15