[1]蔡向杰,屈云萍,王亚涛,等.响应曲面-多指标评价法优化枳椇子提取工艺[J].西部中医药,2018,31(04):37-41.
　CAI Xiangjie,QU Yunping,WANG Yatao,et al.Extraction Technology of ZhiJuZi Optimizedby Response Surface-multiple Index Evaluation Method[J].Western Journal of Traditional Chinese Medicine,2018,31(04):37-41.
点击复制

响应曲面-多指标评价法优化枳椇子提取工艺()
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年04期
页码:
37-41
栏目:
出版日期:
2018-04-15

文章信息/Info

Title:
Extraction Technology of ZhiJuZi Optimizedby Response Surface-multiple Index Evaluation Method
文章编号:
1004-6852(2018)04-0037-05
作者:
蔡向杰1，屈云萍1，王亚涛1，李哲1，姜国志2
1 神威药业集团有限公司，河北 石家庄 051400； 2 中药注射剂新药技术开发国家地方联合工程实验室
Author(s):
CAI Xiangjie1, QU Yunping1, WANG Yatao1, LI Zhe1, JIANG Guozhi2
1 China Shineway Pharmaceutical Group Ltd., Shijiazhuang 051400, China; 2 State-local Joint Engineering Laboratory of New Drugs Development Technology for TCM Injection
关键词:
枳椇子; 皂苷; 总黄酮; 收率; 响应曲面-多指标评价法; 提取工艺
Keywords:
ZhiJuZi;  saponin;  total flavonoids;  yield;  response surface-multiple index evaluation method;  extraction technology
分类号:
R282
文献标志码:
A
摘要:
目的：以枳椇子为原料，利用响应曲面-多指标评价法优化枳椇子的提取工艺。方法：在单因素试验的基础上，应用Box-Behnken设计方法建立数学模型，选择提取时间、溶剂倍数、提取次数为影响因子，以枳椇子干膏粉中皂苷含量、总黄酮含量及干膏收率3个指标为响应值，进行响应曲面分析。结果：枳椇子的最佳工艺条件为提取时间2小时、提取次数4次、溶剂倍量8倍量。结论：提取工艺与模型高度拟合，可以用于工业生产。
Abstract:
Objective: To optimize the extraction technology of ZhiJuZi (Citrus trifoliata) by using response surface-multiple index evaluation method and taking ZhiJuZi as the raw material. Methods: Based on single factor test, Box-Behnken design technique was used to build mathematical models, response surface analysis was performed by choosing extraction time, solvent multiple, extraction times as the influencing factors and taking three indexes of the contents of saponin and total flavonoids contained in dry paste of ZhiJuZi, and dry paste yield as the response values. Results: The best technological condition of ZhiJuZi was extraction time: two hours, extraction times: four times, solvent multiple: eight times. Conclusion: The extraction technology which agreed with the model highly could be applied to industrial production.

相似文献/References:

[1]金国泰,李 博,王树荣△.柴胡解热的物质基础、药效及机制研究[J].西部中医药,2014,27(02):20.
　JIN Guotai,LI Bo,WANG Shurong.Research on the Mechanism, the Effects and Material Foundation of ChaiHu in Relieving Fever[J].Western Journal of Traditional Chinese Medicine,2014,27(04):20.
[2]葛秀允,孙立立△.蜜炙对黄芪饮片免疫活性的影响[J].西部中医药,2019,32(04):5.
　GE Xiuyun,SUN Lili.Experimental Study of the Influence of Frying with Honey on Immunological Competence of HuangQi Decoction Pieces[J].Western Journal of Traditional Chinese Medicine,2019,32(04):5.

备注/Memo

备注/Memo:
收稿日期：2017-08-28 *基金项目：国家中医药管理局中医药科学技术研究专项课题(编号国中医药科2013ZX07)；河北省科技计划项目(编号14272504D) 作者简介：蔡向杰(1984—)，女，工程师。研究方向：中药配方颗粒和保健食品工艺及质量研究。
更新日期/Last Update: 2018-04-15