[1]郑奇辉,王迎斌△,刘伟,等.梓醇对坐骨神经结扎模型神经病理性疼痛的影响[J].西部中医药,2018,31(05):11-13.
 ZHENG Qihui,WANG Yingbin,LIU Wei,et al.Effects of Catalpol on the Neuropathic Pain in Rat Model with Chronic Constriction Injury[J].Western Journal of Traditional Chinese Medicine,2018,31(05):11-13.
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梓醇对坐骨神经结扎模型神经病理性疼痛的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年05期
页码:
11-13
栏目:
方药·药理研究
出版日期:
2018-05-15

文章信息/Info

Title:
Effects of Catalpol on the Neuropathic Pain in Rat Model with Chronic Constriction Injury
文章编号:
1004-6852(2018)05-0011-03
作者:
郑奇辉王迎斌△刘伟王书宝黄生辉
兰州大学第二医院麻醉科,甘肃 兰州 730030
Author(s):
ZHENG Qihui WANG Yingbin△ LIU Wei WANG Shubao HUANG Shenghui
Department of Anesthesiology, Lanzhou University Second Hospital, Lanzhou 730030, China
关键词:
坐骨神经结扎疼痛神经病理性梓醇大鼠
Keywords:
sciatic nerve ligation pain neuropathic catalpol rats
分类号:
R244.1
文献标志码:
A
摘要:
目的:观察腹腔注射梓醇对坐骨神经结扎(CCI)大鼠神经病理性疼痛的影响。方法:将雄性SD大鼠56只制作CCI模型,术后4天随机分为假手术组,溶剂组(生理盐水),阳性药物组(巴喷丁50 mg/kg)和梓醇组(1、5、25、125 mg/kg),分别腹腔内注射给药。通过机械刺激缩足反射痛阈值(MWT)及炎症痛觉过敏抑制率(MPE)评估效果。结果:与术前和假手术组比较, 每天给予梓醇治疗可逆转大鼠急性机械性疼痛。腹腔内注射阳性药物及梓醇后,大鼠MPE升高(P<0.05),连续给予梓醇(1、5、25、125 mg/kg)、阳性药物(巴喷丁50 mg/kg)7天后,MPE分别达到(31.94 ±5.64)%、(38.06± 5.78)%、(61.94± 5.14)%、(69.13± 5.12)%、(61.19± 6.18)%。结论:腹腔注射梓醇能够明显降低CCI大鼠的神经病理性疼痛,并有量效关系。
Abstract:
Objective: To observe the effects of catalpol through intraperitoneal injection on the neuropathic pain of the rats with chronic constriction injury (CCI). Methods: Fifty-six male SD rats were established into CCI models, and randomly divided into seven groups at the forth day after the surgery: sham operation group, solvent group (physiological saline), positive medicine group (gabapentin 50 mg/kg); catalpol groups (1, 5, 25 and 125 mg/kg),by intraperitoneal injection. MWT value and MPE value were measured to analyze the effects of catalpol. Results: Compared with before operation and sham operation group, administration of catalpol each day could reverse acute mechanical pain of the rats. After intraperitoneal injection of positive medicine and catalpol, MPE of the rats raised (P<0.05), after consecutive administration of catalpol (1, 5, 25 and 125 mg//kg) and positive medicine (gabapentin50 mg/kg) for seven days consecutively, MPE reached (31.94±5.64)%,( 38.06± 5.78)%,( 61.94±5.14)%,( 69.13±5.12)% and (61.19± 6.18)% respectively. Conclusion: Intraperitoneal injection of catalpol could notably decrease neuropathicpain of CCI rats, which shows dose-dependent relation.

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备注/Memo

备注/Memo:
收稿日期:2017-12-06 *基金项目:甘肃省卫生行业科研计划(编号GSWSKY-2015-61)。 作者简介:郑奇辉(1984—),男,硕士学位,主治医师。研究方向:神经病理性疼痛的机理。 △通讯作者:王迎斌(1970—),男,博士学位,主任医师。研究方向:神经病理性疼痛的发生机理。
更新日期/Last Update: 2018-05-15