[1]折哲,石克华△.复方佛耳草合剂对慢性阻塞性肺疾病急性加重患者气道炎症的影响[J].西部中医药,2018,31(09):5-8.
　ZHE Zhe,SHI Kehua.Effects of Compound FoErCao Mixture on Airway Inflammation of AECOPD Patients[J].Western Journal of Traditional Chinese Medicine,2018,31(09):5-8.
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复方佛耳草合剂对慢性阻塞性肺疾病急性加重患者气道炎症的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年09期
页码:
5-8
栏目:
出版日期:
2018-09-15

文章信息/Info

Title:
Effects of Compound FoErCao Mixture on Airway Inflammation of AECOPD Patients
文章编号:
1004-6852(2018)09-0005-04
作者:
折哲，石克华△
上海中医药大学附属市中医医院，上海 200071
Author(s):
ZHE Zhe, SHI Kehua△
Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai 200071, China
关键词:
慢性阻塞性肺疾病; 气道炎症; 肺功能; 起效时间; IL-8; 复方佛耳草合剂
Keywords:
chronic obstructive pulmonary disease;  airway inflammation;  pulmonary function;  onset time;  IL-8;  compound FoErCao mixture
分类号:
R563.8
文献标志码:
A
摘要:
目的：观察复方佛耳草合剂对慢性阻塞性肺疾病(COPD)急性加重患者气道炎症的影响。方法：将COPD急性加重患者107例随机分为治疗组51例和对照组56例。2组常规治疗后，对照组给予复方佛耳草合剂模拟剂，治疗组给予复方佛耳草合剂，均服用14天。观察2组患者主要症状缓解起效时间、肺功能指标、炎症因子水平变化情况。结果：1)治疗后2组患者主要症状(咳嗽、咯痰)缓解起效时间比较差异具有统计学意义(P＜0.05)；2)2组患者第1秒用力呼气容积(FEV1)、第1秒用力呼气容积占预计值百分比(FEV1%)、用力肺活量(FVC)均较治疗前改善，差异有统计学意义(P＜0.05)。治疗后2组患者FEV1、FEV1%、FVC比较差异具有统计学意义(P＜0.05)。3)治疗后2组患者白细胞介素8(IL-8)水平较治疗前降低，差异有统计学意义(P＜0.05)，治疗后2组患者IL-8水平比较差异具有统计学意义(P＜0.05)。4)肺功能指标与炎症因子IL-8水平呈负相关。结论：复方佛耳草合剂联合西药治疗可迅速缓解患者咳嗽、咯痰症状，降低炎症因子水平，改善患者肺通气指标。
Abstract:
Objective: To observe the effects of compound FoErCao mixture on airway inflammation of the patients with acute exbaceration chronic obstructive pulmonary disease (AECOPD). Methods: All 107 AECOPD patients were randomized into 51 cases of the treatment group and 56 cases of the control group. After conventional therapy, the control group accepted the placebo of compound FoErCao mixture, and the treatment group took compound FoErCao mixture, they took for 14 days consecutively. The changes of inflammatory factors levels, the indexes of pulmonary function and the onset time of main symptoms of the patients were observed. Results: 1) The difference had statistical meaning in the comparisons of the onset time of main symptoms (cough and coughing up phlegm) between both groups after treating(P＜0.05); 2) FEV1, FEV1% and FVC of both groups were improved compared with before treating, and the difference had statistical meaning(P＜0.05). The difference showed statistical meaning in the comparisons of FEV1, FEV1% and FVC between both groups after treating(P＜0.05). 3) The levels of IL-8 decreased after treating in both groups compared with before treating, and there was a significant difference (P＜0.05), the difference was statistically significant in the comparisons of the levels of IL-8 between both groups after treating(P＜0.05). 4)The indexes of pulmonary function were negatively related to the levels of IL-8. Conclusion: Compound FoErCao mixture in combination with western medicine could rapidly relieve the symptoms such as cough, coughing up phlegm of the patients, lower the level of inflammatory factors and improve the indexes of pulmonary ventilation.

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备注/Memo

备注/Memo:
收稿日期：2018-02-20 *基金项目：国家中医药管理局国家中医临床研究基地业务 建设科研专项课题(编号JDZX2015231)；上海市科学技术委员会科研计划项目(编号13401902202)。 作者简介：折哲(1981—)，女，硕士学位，主治医师。研究方向：呼吸系统疾病的中西医治疗。 △通讯作者：石克华(1963—)，女，硕士学位，主任医师。研究方向：呼吸系统疾病的中西医诊治。
更新日期/Last Update: 2018-09-15