中医药对Dll4-Notch信号通路及血管再生影响的研究-《西部中医药》

文章信息/Info

Title:: Research Status of the Effects of Traditional Chinese Medicine on D114-Notch Signaling Pathway and Revascularization

Author(s):: HE Zhijun, YAO Xingzhang, LI Shenghua, ZHAO Ping, JIANG Zhenxing; Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China

Keywords:: D114-Notch signaling pathway; revascularization; traditional Chinese medicine

摘要:: 从Dll4-Notch信号通路、中医药对Dll4-Notch信号通路影响的研究、中医药对血管再生影响的研究3方面入手探讨中医药对Dll4-Notch信号通路、血管再生的影响，指出Dll4-Notch信号通路是研究较多的、较为成熟的抗肿瘤血管再生的通路，其机理为阻断该通路而抑制血管再生，而通过介导Dll4-Notch信号通路来促进血管生成方面的研究未见报道，这将成为中医药在创伤、显微外科组织修复方面新的研究方向，能够进一步丰富中医药理论。

Abstract:: The effects of traditional Chinese medicine on D114-Notch signaling pathway and revascularization are discussed from the aspects of D114-Notch signaling pathway, study on the effects of TCM on D114-Notch signaling pathway and the study on the effects of TCM on revascularization, it is pointed out that D114-Notch signaling pathway is one of the more mature and effective approaches to fight against tumor revascularization, and its mechanism is to block the pathway and inhibit revascularization, while the study on mediating D114-Notch signaling pathway to promote revascularization has never been reported, and it would become the new research direction for TCM in trauma and microsurgical tissue repair, which could further enrich the theory of TCM.