[1]笱玉兰,张静,陈春鹏,等.定痫汤加味对风痰闭阻型耐药性癫痫患者外周血P-糖蛋白的影响[J].西部中医药,2019,32(02):89-91.
　GOU Yulan,ZHANG Jing,CHEN Chunpeng,et al.Effects of Modified DingXian Decoction on P-glycoprotein in Peripheral Blood of the Patients with Drug Resistant Epilepsy of Wind-phlegm Blocking Pattern[J].Western Journal of Traditional Chinese Medicine,2019,32(02):89-91.
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定痫汤加味对风痰闭阻型耐药性癫痫患者外周血P-糖蛋白的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
32
期数:
2019年02期
页码:
89-91
栏目:
出版日期:
2019-02-15

文章信息/Info

Title:
Effects of Modified DingXian Decoction on P-glycoprotein in Peripheral Blood of the Patients with Drug Resistant Epilepsy of Wind-phlegm Blocking Pattern
文章编号:
1004-6852(2019)02-0089-03
作者:
笱玉兰1，张静1，2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2，陈春鹏1，2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2，张晓敏1，2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2，李静1，2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2，周莲芝1，2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2
1 武汉市第一医院神经内科，湖北 武汉 430022； 2 湖北中医药大学
Author(s):
GOU Yulan1, ZHANG Jing1, 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2, CHEN Chunpeng1, 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2, ZHANG Xiaomin1, 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2, LI Jing1, 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2, ZHOU Lianzhi1, 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2' target="_blank" rel="external"> 2
1 Neurology Department, Wuhan No.1 Hospital, Wuhan 430022, China; 2 Hubei University of Chinese Medicine
关键词:
耐药性癫痫; 风痰闭阻证; 定痫汤; P-糖蛋白
Keywords:
drug-resistant epilepsy;  wind-phlegm blocking pattern;  DingXian decoction;  P-glycoprotein
分类号:
R971+.6
文献标志码:
B
摘要:
目的：探讨定痫汤加味对风痰闭阻型耐药性癫痫(DRE)患者外周血P-糖蛋白(P-gp)的影响。方法：在维持原有抗癫痫药(AEDs)治疗基础上，给予37例耐药性癫痫患者定痫汤加味治疗，连续治疗24周，记录初诊、治疗后12周及24周癫痫患者的癫痫发作次数、持续时间；检测初诊时、治疗后12周及24周患者外周血P-gp的水平。结果：癫痫发作次数及发作持续时间，初诊时高于治疗后12周及24周差异有统计学意义(P＜0.05)。外周血P-gp含量，与初诊时比较治疗后12周及24周含量降低，差异有统计学意义(P＜0.05)。结论：定痫汤加味治疗风痰闭阻型DRE患者，能降低患者外周血P-gp的含量，减少癫痫发作次数，缩短持续时间。
Abstract:
Objective：To explore the effects of modified DingXian decoction on P-glycoprotein (P-gp) in peripheral blood of the patients with drug resistant epilepsy (DRE) of wind-phlegm blocking pattern. Methods: Forty DRE patients were given modified DingXian decoction on the foundation of maintaining antiepileptic drugs (AEDs), they were treated for 24 weeks consecutively, epileptic seizure frequency and duration of the patients were recorded 12 weeks before treating, 12 weeks after treating and 24 weeks; the levels of P-gp in peripheral blood of the patients at the first visit, in 12 weeks after treating and 24 weeks were detected. Results: The times of epileptic seizure and duration 12 weeks before the first weeks were higher than these in 12 weeks after treating and 24 weeks (P＜0.05). The contents of P-gp in peripheral blood reduced in 12 weeks after treating and in 24 weeks compared with the first visit (P＜0.05). Conclusion: Modified DingXian decoction in treating DRE patients of wind-phlegm blocking pattern could reduce the contents of P-gp in peripheral blood, decrease epileptic seizure frequency and shorten the duration.

备注/Memo

备注/Memo:
收稿日期：2018-07-05 *基金项目：湖北省自然科学基金重点项目(编号2013CFB365)。 作者简介：笱玉兰(1974—)，女，博士学位，主任医师。研究方向：中西医结合治疗神经与精神疾病。
更新日期/Last Update: 2019-02-15