[1]姜敏.自拟黄归汤联合来氟米特对糖尿病肾病患者血清色素上皮源因子水平的影响[J].西部中医药,2020,33(S1):97-98.
 Jinag Min.Effect of self-made Huanggui Decoction combined with leflunomide on serum pigmented epithelial factor level in patients with diabetic nephropathy[J].Western Journal of Traditional Chinese Medicine,2020,33(S1):97-98.
点击复制

自拟黄归汤联合来氟米特对糖尿病肾病患者血清色素上皮源因子水平的影响()
分享到:

《西部中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
33
期数:
2020年S1
页码:
97-98
栏目:
报道·衷中参西
出版日期:
2025-06-30

文章信息/Info

Title:
Effect of self-made Huanggui Decoction combined with leflunomide on serum pigmented epithelial factor level in patients with diabetic nephropathy
作者:
姜敏
武威市人民医院肾内科 甘肃 武威 733000
Author(s):
Jinag Min
Wuwei,Wuwei 733000,China
关键词:
自拟黄归汤来氟米特糖尿病肾病血清色素上皮源因子水平不良反应
Keywords:
Self-made Huanggui Decoction Leflunomide Diabetic Nephropathy Serum Pigment Epithelial Source Factor Level Adverse Reactions
摘要:
目的 探讨自拟黄归汤联合来氟米特对糖尿病肾病患者血清色素上皮源因子水平的影响。方法 选取2017年3月-2018年3月我院收治的132例糖尿病肾病患者,随机分为三组,对照1组应用自拟黄归汤治疗,对照2组应用来氟米特治疗,研究组应用自拟黄归汤联合来氟米特治疗,并对三组患者进行护理干预。比较三组患者治疗效果、不良反应发生率、指标改善情况、肾功和炎性因子指标。结果研究组不良反应发生率低于对照组1组和对照2组(P<0.05);研究组指标改善情况好于对照组1组和对照2组(P<0.05);治疗后,研究组肾功能优于对照组1组和对照2组(P<0.05);研究组炎性因子指标好于对照1组和对照2组(P<0.05);研究组治疗效果好于对照1组和对照2组(P<0.05)。结论 对糖尿病肾病患者,进行自拟黄归汤联合来氟米特治疗,治疗效果理想,降低了患者血清色素上皮源因子水平和不良反应发生率,改善了患者病情。因此,自拟黄归汤联合来氟米特在糖尿病肾病临床治疗中应进一步推广和应用。
Abstract:
Objective To investigate the effect of self-made Huanggui Decoction combined with leflunomide on serum levels of pigmented epithelial factor in patients with diabetic nephropathy. Methods 132 patients with diabetic nephropathy admitted to our hospital from March 2017 to March 2018 were randomly divided into three groups. The control group was treated with self-made Huanggui Decoction and the control group was treated with leflunomide. The study group was treated with self-made Huanggui decoction combined with leflunomide. Nursing intervention was given to the three groups. The therapeutic effect, incidence of adverse reactions, improvement of indicators, renal function and inflammatory factors were compared among the three groups. Results The incidence of adverse reactions in the study group was lower than that in the control group 1 and 2 (P < 0.05); the improvement of indicators in the study group was better than that in the control group 1 and 2 (P < 0.05); after treatment, the renal function in the study group was better than that in the control group 1 and 2 (P < 0.05); the inflammatory factors in the study group were better than those in the control group 1 and 2 (P < 0.05); and the therapeutic effect in the study group was better than that in the control group 1 and 2 (P < 0.05 Group A and control group 2 (P < 0.05). Conclusion For patients with diabetic nephropathy, self-made Huanggui Decoction combined with leflunomide is effective, reducing the level of serum pigmented epithelial factor and the incidence of adverse reactions, and improving the patient’s condition. Therefore, self-made Huanggui Decoction combined with leflunomide should be further promoted and applied in the clinical treatment of diabetic nephropathy.

参考文献/References:


[1]李易,田鲁,王港, 等.苦瓜总皂苷对2型糖尿病肾病大鼠肾脏组织中单核细胞趋化蛋白1表达的影响[J].西部中医药,2017,1(6):8-12.
[2]宋红霞,薛晓东.消银汤对银屑病样模型小鼠TNF-α及IL-10的影响[J].西部中医药,2018,3 (1):16-18.
[3]赵妮,谢新荣,赵巧玲, 等.中药联合替米沙坦片治疗2型糖尿病肾病的临床疗效观察[J].中华中医药学刊,2017,2(08):230-232.
[4]申子龙,赵进喜,吴文静,等.糖尿病肾脏病免疫炎性反应机制及中西医治疗进展[J].中华中医药杂志,2017,2(10):243-247.
[5]杨乐斌,项磊,蒋平平, 等.芪丹地黄颗粒治疗2型糖尿病肾病的实验研究[J].辽宁中医杂志,2017,1(06):1304-1307
[6]郭杨志,杜娟,冯兴中, 等.大剂量黄连对糖尿病肾病大鼠糖化血红蛋白、TNF-α及肾脏病理的影响[J].时珍国医国药,2017,2(04):68-70.
[7]黄仕鑫,罗佳婧,罗亚玲, 等.基于BP神经网络模型鉴别2型糖尿病肾病的认知图研究[J].中华内分泌代谢杂志,2017,33(11):943-949.
[8]陈小永,王自闯,郭存霞, 等.当归补血汤合六味地黄汤对高血压肝肾阴虚证早期肾损害的防治[J].中国实验方剂学杂志,2017,2(09):198-203.
[9] Mollania F , Raissi H . Evaluation of solvent and ion effects upon leflunomide adsorption characteristics on (6,0) zigzag single-walled carbon nanotube and immobilized dihydroorotate dehydrogenase activity: A computational DFT and experimental study[J]. Journal of Molecular Liquids, 2017, 231(4):528-541.
[10]刘军辉,唐璐瑶,侯世会, 等.Slit2/Robo1信号通路蛋白在早期糖尿病肾病肾小球中的表达及临床意义[J].第三军医大学学报,2017,2(1):60-66.
[11]奚悦,李敬林.三黄糖肾康颗粒对早期糖尿病肾病模型大鼠微炎症状态的影响[J].中国全科医学,2017,2(30):69-74.
[12]Cardili L , Wrublevsky Pereira, Gregório, Viana C R . A rare case of TFE-related pigmented renal tumor with overlapping features between melanotic Xp11 translocation renal cancer and Xp11 renal cell carcinoma with melanotic features[J]. Pathology International, 2017, 67(4):208-213.
[13]戴新新,蔡红蝶,宿树兰, 等.地黄叶对糖尿病肾病大鼠肠道菌群的调节作用[J].药学学报,2017,1(11):1683-1691.
[14]吴欣,黄健,刘畅, 等.1,25-二羟维生素D3对2型糖尿病肾病患者血管生成素样蛋白4水平的影响[J].实用医学杂志,2017,33(13):2201-2204.
[15]Huang A , Brody N , Liebman T N . Dihydroxyacetone and sunless tanning: Knowledge, myths, and current understanding[J]. Journal of the American Academy of Dermatology, 2017, 77(5):991-992.
[16]杨文军,李丽,张新颖.注射用红花黄色素治疗老年人早期糖尿病肾病的Meta分析[J].中华老年医学杂志,2018,37(1):84-88.
[17]Shiroto Y , Terashima S , Hosokawa Y , et al. The Effect of Ultraviolet B on Fibrillin-1 and Fibrillin-2 in Human Non-pigmented Ciliary Epithelial Cells In Vitro[J]. Acta Histochemica Et Cytochemica, 2017, 50(3):105-109.
[18]薛梅,卞勇,周俊杰, 等.当归补血汤主要吸收成分对GK大鼠肾保护作用研究[J].南京中医药大学学报,2018,34(2):190-193.
[19]Li J , Das J R , Tang P , et al. Transmembrane TNF-α Facilitates HIV-1 Infection of Podocytes Cultured from Children with HIV-Associated Nephropathy.[J]. Journal of the American Society of Nephrology, 2017, 28(3):862-875.
[20]常洁,董少卿,郭志玲.百令胶囊联合来氟米特治疗慢性肾小球肾炎的临床研究[J].现代药物与临床,2019,34(02):438-441..

相似文献/References:

[1]张晓琴,何东初.复方玄驹胶囊联合甲氨蝶呤、来氟米特治疗类风湿关节炎40例[J].西部中医药,2012,25(05):78.
 ZHANG Xiao-qin,HE Dong-chu.Treatment of Rheumatoid Arthritis with Compound XuanJu Capsule combined with Methotrexate and Leflunomide: A Report of 40 Cases[J].Western Journal of Traditional Chinese Medicine,2012,25(S1):78.

备注/Memo

备注/Memo:
收稿日期: 2020-08-12作者简介: 姜敏 (1983—), 女, 硕士, 主治医师。研究方向: 肾脏疾病。
更新日期/Last Update: 2021-03-01