[1]崔健,韦丽富,马家宝,等.益心安神汤对睡眠及睡眠时相的影响[J].西部中医药,2020,33(01):18.[doi:10.12174/j.issn.1004-6852.2020.01.05]
　CUI Jian,WEI Lifu,MA Jiabao,et al.Study on the Effects of Yixin Anshen Tang on Sleep and Sleep Phase[J].Western Journal of Traditional Chinese Medicine,2020,33(01):18.[doi:10.12174/j.issn.1004-6852.2020.01.05]
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益心安神汤对睡眠及睡眠时相的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
33
期数:
2020年01期
页码:
18
栏目:
出版日期:
2020-01-15

文章信息/Info

Title:
Study on the Effects of Yixin Anshen Tang on Sleep and Sleep Phase
文章编号:
1004-6852(2020)01-0018-03
作者:
崔健，韦丽富，马家宝，王有琼，梁霜，杨正腾△
广西中医药大学第一附属医院，广西 南宁 530023
Author(s):
CUI Jian, WEI Lifu, MA Jiabao, WANG Youqiong, LIANG Shuang, YANG Zhengteng△
the First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China
关键词:
失眠; 催眠; 睡眠时相; 戊巴比妥纳; 益心安神汤; 大鼠
Keywords:
insomnia;  hypnosis;  sleep phase;  carbrital;  Yixin Anshen Tang;  rats
分类号:
R692
DOI:
10.12174/j.issn.1004-6852.2020.01.05
文献标志码:
A
摘要:
目的：探讨益心安神汤对睡眠及睡眠时相的影响。方法：通过小鼠翻正实验及大鼠脑电波分析方法，分别记录小鼠睡眠潜伏期、持续时间及大鼠睡眠时相的觉醒期(the waking phase of sleep,WAKE)、慢波睡眠第一期(slow-wave sleep phase 1,SWS1)、慢波睡眠第二期(slow-wave sleep phase 2,SWS2)、快速眼球运动睡眠期(rapid eye movement sleep,REMS)。结果：益心安神汤在戊巴比妥纳的诱导下能延长小鼠睡眠持续时间，但对睡眠潜伏期未产生影响，能缩短正常大鼠及失眠大鼠睡眠周期wake期，延长SWS1、SWS2及REMS期。结论：益心安神汤能增加小鼠及失眠大鼠的睡眠持续时间。
Abstract:
Objective: To discuss the effects of Yixin Anshen Tang on sleep and sleep phase. Methods: Mice righting reflex and rat brain wave analysis method were used to record mice sleep latency, duration, the phases of WAKE, slow wave sleep in phase one (SWS1), slow wave sleep in phase two (SWS2) and rapid eye movement sleep (REMS) of rats. Results: Yixin Anshen Tang could prolong mice sleep duration induced by carbrital, but produce no effects on sleep latency, it could shorten wake phase of normal rats and insomnia rats in sleep cycle, and prolong the phases of SWS1, SWS2 and REMS. Conclusion: Yixin Anshen Tang could increase sleep duration of mice and insomnia rats.

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备注/Memo

备注/Memo:
收稿日期：2018-12-27*基金项目：广西中医药民族医药自筹经费科研课题(GZZC15-07)。作者简介：崔健(1988—)，女，硕士学位，主管药师。研究方向：临床药理分析。△通讯作者：杨正腾(1970—)，男，硕士学位，副主任药师。研究方向：药物分析。
更新日期/Last Update: 2020-01-15