[1]闫方杰,姜侠,李学成.全当归水煎液补血/活血作用的量效关系研究[J].西部中医药,2020,33(03):30-33.[doi:10.12174/j.issn.1004-6852.2020.03.08]
 YAN Fangjie,JIANG Xia,LI Xuecheng.Study on Dose-effects Relationship between Enriching Blood and Activating Blood of QuanDanggui Decoction[J].Western Journal of Traditional Chinese Medicine,2020,33(03):30-33.[doi:10.12174/j.issn.1004-6852.2020.03.08]
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全当归水煎液补血/活血作用的量效关系研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
33
期数:
2020年03期
页码:
30-33
栏目:
方药·药理研究
出版日期:
2020-03-15

文章信息/Info

Title:
Study on Dose-effects Relationship between Enriching Blood and Activating Blood of QuanDanggui Decoction
文章编号:
1004-6852(2020)03-0030-04
作者:
闫方杰姜侠李学成
1 山东中医药高等专科学校,山东 烟台 264199; 2 滨州医学院; 3 烟台市牟平区中医医院
Author(s):
YAN Fangjie1 JIANG Xia2△ LI Xuecheng3
1 Shandong College of Traditional Chinese Medicine, Yantai 264199, China;2 Binzhou Medical University; 3 Muping District TCM Hospital of Yantai City
关键词:
全当归水煎液补血活血量效关系大鼠
Keywords:
QuanDanggui decoction enriching blood activating blood dose-effect relationship rats
分类号:
R284.1
DOI:
10.12174/j.issn.1004-6852.2020.03.08
摘要:
目的:探讨全当归水煎液补血、活血作用的量效关系。方法:将SD大鼠90只随机分为空白对照组10只,血虚证组40只(血虚模型组及全当归水煎液大、中、小剂量组各10只),血瘀证组40只(血瘀模型组及全当归水煎液大、中、小剂量组各10只),血虚及血瘀证全当归水煎液大、中、小剂量组每日分别灌胃相应剂量全当归水煎液,空白对照组、血虚及血瘀模型组灌胃等剂量生理盐水,4天后检测血虚证各组血常规指标及血瘀证各组血液流变学指标。结果:与空白对照组比较,除血小板(platelets,PLT)外血虚证各剂量组及模型组血常规指标均降低,差异有统计学意义(P<0.01),但模型组与各剂量组间各指标比较差异均无统计学意义(P>0.05)。血瘀证血流变指标模型组与空白对照组相比各项指标增高,差异有统计学意义(P<0.05);全血高切200/S、中切30/S、高切还原黏度、红细胞电泳时间及红细胞压积中剂量组与大剂量组比较,差异有统计学意义(P<0.05)。结论:因受课题经费与时间限制,样本量较低;实验大鼠与人体对当归药效反应的差异性、中药的药效与实验室检查指标的差异性以及受实验条件、实验仪器所限,难以取够血量支持其他指标的检测等相关因素导致本实验不能验证“当归用量增大时,其补血的功效更加明显,而用量减少时,其活血的功效增强”这一观点的正确性。
Abstract:
Objective: To explore the dose-effect relationship between enriching blood and activating blood of QuanDanggui (angelicae sinensis radix) decoction. Methods: All 90 SD rats were randomized into ten rats of blank control group, 40 rats of blood deficiency pattern group (blood deficiency model group, large dose group, moderate dose group and low dose group, ten rats each group), and 40 rats of blood stagnation pattern group(blood stagnation model group, large dose group, moderate dose group and low dose group, ten rats each group). Large, moderate and low dose groups of blood deficiency and blood stagnation pattern were drenched with the corresponding doses of QuanDanggui decoction respectively each day, blank control group, the model groups of blood deficiency and blood stagnation patterns with the equivalent dose of physiological saline, to detect blood routine indexes in different groups of blood deficiency pattern and hemorheological indexes in different groups of blood stagnation pattern in four days. Results: Compared with blank control group, blood routine indexes of different dosage groups of blood dificiencypattern and the model group reduced except PLT, and the difference had statistical meaning(P<0.05), while the difference had no statistical meaning in the comparisons of different indexes between the model group and different dosage groups(P>0.05). When the model group of blood stagnation pattern was compared with blank control group, different hemorheological indexes rose, and the difference showed statistical meaning(P<0.05); when whole blood high shear viscosity 200/S, moderate shear 30/S, high shear reduction viscosity,erythrocyte electropho-resis time and hematocrit of the moderate dose group were compared with these of high dose group, and the diffrence had statistical meaning(P<0.05).Conclusion: The experiment couldn't verify the view of "the blood-enriching effects are more notable when the dose of QuanDanggui increased, its blood-activating effects are ehanced while the dose reduced" because of time limit and limited project funding, lower sample size; the difference of pharmacodynamic response of experimental rats and human body to QuanDanggui, the efficacy of TCM, the difference in lab test indexes, enough blood couldn't been drawn to support the detection of other indexes and the other related factors.

备注/Memo

备注/Memo:
收稿日期:2019-03-27*基金项目:山东省高等学校科技计划项目(J15LM61)。作者简介:闫方杰(1980—),男,副教授。研究方向:中医学辨证思维研究。△通讯作者:姜侠(1981—),女,博士学位,副教授。研究方向:中医学辨证思维研究。
更新日期/Last Update: 2020-03-15