[1]王倩凤,詹丽,魏小果,等.药物性肝炎的临床特征分析[J].西部中医药,2020,33(04):90-92.[doi:10.12174/j.issn.1004-6852.2020.04.27]
　WANG Qianfeng,ZHAN Li,WEI Xiaoguo,et al.Clinical Analysis of the Characteristics of Drug Hepatitis[J].Western Journal of Traditional Chinese Medicine,2020,33(04):90-92.[doi:10.12174/j.issn.1004-6852.2020.04.27]
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药物性肝炎的临床特征分析
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
33
期数:
2020年04期
页码:
90-92
栏目:
出版日期:
2020-04-15

文章信息/Info

Title:
Clinical Analysis of the Characteristics of Drug Hepatitis
文章编号:
1004-6852(2020)04-0090-03
作者:
王倩凤，詹丽，魏小果，李娟，杨帆，何昉，李昌金
甘肃省人民医院干部消化科,甘肃 兰州 730000
Author(s):
WANG Qianfeng, ZHAN Li, WEI Xiaoguo, LI Juan, YANG Fan, HE Fang, LI Changjin
Cadre Gastroenterology Department, Gansu Provincial Hospital, Lanzhou 730000, China
关键词:
药物性肝炎; 中药; 西药; 临床特征
Keywords:
durg hepatitis;  TCM;  Westerm medicine;  clinical characteristics
分类号:
R322.4+7
DOI:
10.12174/j.issn.1004-6852.2020.04.27
文献标志码:
A
摘要:
目的:分析中药与西药所诱导的药物性肝炎的临床特征。方法：回顾性分析2014年9月至2018年12月甘肃省人民医院收治的151例药物性肝炎患者的临床资料，并进行临床特征分析。结果：大部分药物性肝炎的严重程度为中度及以上，其中由中药诱发的中度/重度/肝衰三级占比分别为：26.32%(15/57)、42.11%(24/57)及 12.28%(7/57)，西药诱发占比分别为28.77%(21/73)、27.40%(20/73)及0.00%(0/73)，中西药占比分别为28.57%(6/21)、33.33%(7/21)及4.76%(1/21)。西药诱发的药物性肝炎中肝细胞型占79.45%(58/73)，胆汁淤积型占6.85%(5/73)，混合型占13.70%(10/73)。中药诱发的药物性肝炎肝细胞型及胆汁淤积型均占38.60%(22/57)，混合型占22.80%(13/57)。中西药诱发的药物性肝炎肝细胞型占61.91%(13/21)，胆汁淤积型占28.57%(6/21)，混合型 占9.52%(2/21)。结论：西药与中药在导致药物性肝炎方面存在一定差异，中药引起的药物性肝炎比西药引起的更严重。
Abstract:
Objective: To analyze clinical characteristics of drug hepatitis induced by TCM and Western medicine. Methods: Clinical data of 151 cases of drug hepatitis admitted into Gansu Provincial Hospital from September, 2014 to December, 2018 were retrospectively analyzed, as well as its clinical characteristics. Results: The proportions of TCM inducing drug hepatitis in grade three to five (moderate, severe and liver failure) were 26.32%(15/57), 42.11%(24/57) and 12.28%(7/57) respectively, the proportions of western medicine were 28.77%(21/73) , 27.40%(20/73) and 0.00%(0/73) respectively, the proportions of TCM and western medicine were 28.57%(6/21), 33.33%(7/21) and 4.76%(1/21) respectively. 79.45%(58/73) of drug hepatitis induced by Western medicine were of hepatocyte type, 6.89%(51/73) of cholestasis type and 13.7%(10/73) of mixed type. 38.60%(22/57) of drug hepatitis induced by TCM of hepatocyte type and cholestasis type and 22.80%(13/57) of mixed type. 61.91%(13/21) of drug hepatitis induced by TCM and western medicine were of hepatocyte type, 28.57%(6/21) of cholestasis type and 9.52%(2/21) of mixed type. Conclusion: There are some differences between Western medicine and TCM in the aspects of inducing drug hepatitis, the hepatitis induced by TCM is more serious than that induced by Western medicine.

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备注/Memo

备注/Memo:
收稿日期：2019-10-20作者简介：王倩凤(1983—)，女，硕士学位，主治医师。研究方向：肝脏疾病的诊治。
更新日期/Last Update: 2020-04-15