[1]焦蕉,郑路丹,黎月恒,等.温经和血通痹方对奥沙利铂化疗后周围神经毒性气血亏虚型患者的影响[J].西部中医药,2020,33(05):75-78.[doi:10.12174/j.issn.1004-6852.2020.05.21]
　JIAO Jiao,ZHENG Ludan,LI Yueheng,et al.Effects of Wenjing Hexue Tongbi Prescription on Peripheral Neurotoxicity of Qi and Blood Deficiency Pattern after Oxaliplatin Chemotherapy[J].Western Journal of Traditional Chinese Medicine,2020,33(05):75-78.[doi:10.12174/j.issn.1004-6852.2020.05.21]
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温经和血通痹方对奥沙利铂化疗后周围神经毒性气血亏虚型患者的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
33
期数:
2020年05期
页码:
75-78
栏目:
出版日期:
2020-05-15

文章信息/Info

Title:
Effects of Wenjing Hexue Tongbi Prescription on Peripheral Neurotoxicity of Qi and Blood Deficiency Pattern after Oxaliplatin Chemotherapy
文章编号:
1004-6852(2020)05-0075-04
作者:
焦蕉，郑路丹，黎月恒，李东芳，唐继云
1 中南大学湘雅医学院附属肿瘤医院，湖南 长沙 410000； 2 湖南中医药大学； 3 衡阳市中医院
Author(s):
JIAO Jiao1，2, ZHENG Ludan2, LI Yueheng1, LI Dongfang1△, TANG Jiyun3
1 The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410000, China; 2 Hunan University of Chinese Medicine; 3 Hengyang City Hospital of TCM
关键词:
周围神经毒性; 气血亏虚; 化疗; 温经和血通痹方; 奥沙利铂; 中医药
Keywords:
peripheral neurotoxicity;  Qi and blood deficiency;  chemotherapy;  Wenjing Hexue Tongbi prescription;  oxaliplatin;  TCM
分类号:
R651
DOI:
10.12174/j.issn.1004-6852.2020.05.21
文献标志码:
B
摘要:
目的：探讨温经和血通痹方内服外用对奥沙利铂化疗所致周围神经毒性气血亏虚型患者的治疗作用。方法：将奥沙利铂化疗所致周围神经毒性气血亏虚型患者72例随机分为中药联合组(温经和血通痹方内服外用)，中药组(温经和血通痹方口服)及对照组(甲钴胺口服联合温水外洗)，治疗28天后观察3组患者治疗前后周围神经毒性分级、生活质量、中医证候积分及安全性。结果：3组患者生活质量功能领域SS评分较治疗前升高；3组患者治疗后周围神经毒性、生活质量功能领域SS评分比较差异具有统计学意义（P＜0.05）；中药联合组改善优于其他两组（P＜0.05）。中医证候评分中药联合组、中药组优于对照组（P＜0.01），中药联合组与中药组比较差异无统计学意义(P＞0.05)。治疗前后3组患者生命体征、肝肾功能异常情况比较差异无统计学意义(P＞0.05)。结论：温经和血通痹方内服外用治疗奥沙利铂化疗所致周围神经毒性气血亏虚型患者临床疗效优于温经和血通痹方口服及甲钴胺口服联合温水外洗，且安全性高。
Abstract:
Objective: To explore therapeutic effects of Wenjing Hexue Tongbi prescription(WHTP) for oral administration and external application in the treatment of peripheral neurotoxicity(PN) of Qi and blood deficiency pattern induced by oxaliplatin chemotherapy. Methods: All 72 patients were randomized into herbal combination group (oral administration and external application of WHTP), herbal group (oral administration of WHTP) and the control group (mecobalamin for oral administration and warm water washing), To observe PN classification, quality of life, TCM syndrome integral and the safety of the patients in three groups before and after treating 28 days. Results: SS scores in the functional scores of quality of life in three groups rose compared with before treating; the difference showed statistical meaning in PN, SS scores in the functional scores of quality of life and TCM syndrome scores in three groups after treating (P＜0.05), the improvements of herbal combination group were superior to these of other two groups (P＜0.05). Herbal combination group and herbal group were superior to the control group in TCM syndrome integrals (P＜0.01), the difference had no statistical meaning between herbal combination group and herbal group (P＞0.05). The difference had no statistical meaning in vital signs, abnormal liver and kidney function in three groups before and after treating(P＞0.05). Conclusion: WHTP for oral administration and external application in the treatment of PN of Qi and blood deficiency pattern induced by oxaliplatin chemotherapy are superiior to oral administration of WHTP, and oral mecobalamin combined with warm water washing with high safety.

相似文献/References:

[1]孙长勇,汤久慧,王茂生,等.温阳和血通痹方治疗淋巴瘤化疗相关周围神经毒性疗效观察[J].西部中医药,2018,31(12):60.
　SUN Changyong,TANG Jiuhui,WANG Maosheng,et al.Clinical Observation on WenYang HeXue TongBi Prescription in the Treatment for Chemotherapy-associated Peripheral Neurotoxicity of the Patients with Lymphoma[J].Western Journal of Traditional Chinese Medicine,2018,31(05):60.
[2]孙圆圆,徐霞,王亚洁,等.气血亏虚型神经根型颈椎病中医辨证施护疗效评价的Meta分析[J].西部中医药,2022,35(05):54.[doi:10.12174/j.issn.2096-9600.2022.05.15]
　SUN Yuanyuan,XU Xia,WANG Yajie,et al.Meta Analysis of Effects Evaluation of TCM Syndrome Differentiation and Nursing on Cervical Spondylotic Radiculopathy of Qi-blood Deficiency Pattern[J].Western Journal of Traditional Chinese Medicine,2022,35(05):54.[doi:10.12174/j.issn.2096-9600.2022.05.15]

备注/Memo

备注/Memo:
收稿日期：2019-08-07*基金项目：长沙市科技计划项目(kq1706040)。作者简介：焦蕉(1989—)，女，硕士学位，主治医师。研究方向：恶性肿瘤的中西医结合防治。△通讯作者：李东芳(1970—)，女，硕士学位，主任医师。研究方向：恶性肿瘤的中西医结合防治。
更新日期/Last Update: 2020-05-15