[1]王永军,石良静,等.益气养阴通络方对早期糖尿病肾病患者炎症因子及肾功能的影响[J].西部中医药,2020,33(05):82-85.[doi:10.12174/j.issn.1004-6852.2020.05.23]
 WANG Yongjun,SHI Liangjing,FAN Zhengchao,et al.Influence of Qi-invigorating Yin-nourishing Collateral-dredging Prescription on Inflammatory Factors and Renal Function of the Patients with Early Diabetic Nephropathy[J].Western Journal of Traditional Chinese Medicine,2020,33(05):82-85.[doi:10.12174/j.issn.1004-6852.2020.05.23]
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益气养阴通络方对早期糖尿病肾病患者炎症因子及肾功能的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
33
期数:
2020年05期
页码:
82-85
栏目:
报道·临证经验
出版日期:
2020-05-15

文章信息/Info

Title:
Influence of Qi-invigorating Yin-nourishing Collateral-dredging Prescription on Inflammatory Factors and Renal Function of the Patients with Early Diabetic Nephropathy
文章编号:
1004-6852(2020)05-0082-04
作者:
王永军石良静范正超宫磊贺延法
河北省胸科医院,河北 石家庄 050041
Author(s):
WANG Yongjun SHI Liangjing FAN Zhengchao GONG Lei HE Yanfa△
Hebei Provincial Chest Hospital, Shijiazhuang 050041, China
关键词:
糖尿病肾病早期益气养阴通络方炎症因子肾功能中西医结合
Keywords:
diabetic nephropathy early Qi-invigorating Yin-nourishing collateral-dredging prescription inflammatory factor renal function integrative medicine
分类号:
R587
DOI:
10.12174/j.issn.1004-6852.2020.05.23
文献标志码:
B
摘要:
目的:探讨益气养阴通络方对早期糖尿病肾病患者炎症因子及肾功能的影响。方法:将早期糖尿病肾病患者98例根据随机数字表法分为对照组和观察组各49例。对照组采用缬沙坦治疗,观察组在对照组基础上采用益气养阴通络方治疗,观察两组患者炎症因子水平、肾功能指标、中医证候积分及不良反应情况。结果:观察组治疗后C-反应蛋白(C-reaction protein,CRP)、肿瘤坏死因子α(tumor necrosis factor α,TNF-α)、白细胞介素6(interleukin-6,IL-6)及白细胞介素8(interleukin-8,IL-8)水平均低于对照组,差异有统计学意义(P<0.05);观察组治疗后尿微量白蛋白(m-ALB)、血清胱抑素C(Cys-C)及β2微球蛋白(β2-MG)水平均低于对照组,差异有统计学意义(P<0.05);观察组患者治疗后气短、尿浊、神疲乏力、咽干口燥及肢体浮肿评分均低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率与对照组比较差异无统计学意义(P>0.05)。结论:益气养阴通络方与缬沙坦联用可有效减轻早期糖尿病肾病患者炎症因子水平,改善肾功能及临床症状,且安全性较高。
Abstract:
Objective: To explore the influence of Qi-invigorating Yin-nourishing collateral-dredging prescription(QYCP) on renal function and inflammatory factors of the patients with early diabetic nephropathy(DN). Methods: All 98 early DN patients were allocated to the control group and the observation group according to random number table method, 49 cases each group. The control group were treated by valsartan, and the observation group by QYCP based on valsartan, to observe the levels of inflammatory factors, renal function indexes, TCM syndrome integrals and adverse reaction between both groups. Results: The observation group was lower than the control group in the levels of CRP, TNF-α, IL-6 and IL-8, and the difference had statistical meaning (P<0.05); the observation group was lower than the control group in m-ALB, Cys-C and β2-MG after treating, and the difference was statistically significant(P<0.05); the observation group was lower than the control group in the scores of panting, turbid urine, exhausted, dry throat and mouth and limb swelling after treating, and the difference was statistically significant (P<0.05); the difference had no statistical meaning when the observation group was compared with the control group in the incidence of adverse reaction (P>0.05). Conclusion: QYCP combined with valsartan could effectively lower the levels of inflammatory factors of the patients with early DN, improve renal function and clinical symptoms with higher safety.

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备注/Memo

备注/Memo:
收稿日期:2019-07-17*基金项目:河北省2018年度中医药类科研计划项目(2018085)。作者简介:王永军(1970—),男,硕士学位,副主任医师,副教授。研究方向:心肾内科疾病的诊治。△通讯作者:贺延法(1974—),男,硕士学位,副主任医师。研究方向:心血管疾病的诊治。
更新日期/Last Update: 2020-05-15