[1]高淑美.基于大数据分析“肺与大肠相表里”理论在新型冠状病毒肺炎中的应用[J].西部中医药,2020,33(S1):86-87.
 GAO Shumei.Application of "Exterior-interior Relationship between the Lung and Large Intestine" to COVID-19 Based on Big Data[J].Western Journal of Traditional Chinese Medicine,2020,33(S1):86-87.
点击复制

基于大数据分析“肺与大肠相表里”理论在新型冠状病毒肺炎中的应用()
分享到:

《西部中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
33
期数:
2020年S1
页码:
86-87
栏目:
疫病·新冠肺炎
出版日期:
2025-06-30

文章信息/Info

Title:
Application of "Exterior-interior Relationship between the Lung and Large Intestine" to COVID-19 Based on Big Data
文章编号:
1004-6852(2020)08-0001-04
作者:
高淑美
甘肃医学院,甘肃 平凉 744000
Author(s):
GAO Shumei
Gansu Medical College, Pingliang 744000, China
关键词:
新型冠状病毒肺炎肺与大肠相表里方药基因大数据
Keywords:
COVID-19 exterior-interior relationship between the lung and large intestine prescription and herbs
分类号:
R563.1
文献标志码:
A
摘要:
目的:整理分析与“肺与大肠相表里”理论相关的研究文献,为新型冠状病毒肺炎(Corona Virus Disease 2019,COVID-19)(简称新冠肺炎)的治疗提供新的思路和参考依据。方法:在中国知识基础设施工程文献数据库检索有关“肺与大肠相表里”“新冠肺炎”的相关研究文献,按照文献纳入标准,使用bibexcel软件绘制关键词矩阵,采用VOSviewer软件绘制网络图谱。分析相关文献中涉及与新冠肺炎有关的方药、核心方剂、基因名称及研究中出现的高频关键词。结果:从该理论所涉及的方药来看,核心中药以生地黄、玄参、火麻仁为主,主要功效是清热凉血、润肠通便。核心方剂以射干麻黄汤、清热化痰通腑方、宣白承气汤为主,其主要功效是清肺泻下止咳;从涉及的基因来看,处于核心地位的有辅助性T细胞17(T helper cell 17,Th17)、干扰素γ(interferon γ,IFN-γ)、白细胞介素6(interleukin-6,IL-6),其主要机制可能是通过破坏肠道菌群微生态平衡;“肺与大肠相表里”理论与新冠肺炎相关性研究的核心关键词有宣畅气机、开窍醒神、达原饮、肺炎、细胞因子风暴,说明要重视细胞因子风暴参与的机制研究以及在辨证论治的基础上应用达原饮。结论:为了更好地治疗新冠肺炎,应以“肺与大肠相表里”为指导原则,临证中注意调节患者呼吸功能与大肠传导功能,治疗时注重保持患者肠道菌群的平衡,保持大便通畅,达到标本同治的目的。
Abstract:
Objective: To provide new thinking and reference for the therapy of COVID-19 by arranging and analyzing the research literature related to the theory "exterior-interior relationship between the lung and large intestine". Methods: The literature related to the theory "exterior-interior relationship between the lung and large intestine" and COVID-19 were searched in CNKI, according to literature inclusion criteria, bibcexcel software was used to draw keyword matrix, VOS viewer software was adopted to draw network map. To analyze the herbs and prescription for COVID-19, core prescription, genetic name and high-frequency keywords appeared in the study in the related literature. Results: According to the prescripions and herbs involved in the theory, the core herbs were Shengdihuang (Rehmannia glutinosa Libosch.), Xuanshen (Scrophulariae Radix) and Huomaren (Cannabis Fructus) mainly, its main effects were heat-clearing blood-cooling, loosening bowel to relieve constipation. The core prescriptions were Shegan Mahuang Tang, Qingre Huatan Tongfu prescription, Xuanbai Chengqi Tang and others, and its main effects were clearing lung, purgation and relieving cough; according to the genes, the core genes were Th17 cells, IFN-γ and IL-6, and its main mechanism might be through destroying the microecological balance of intestinal flora; the core keywords of the related study between the theory and COVID-19 were dispersing Qi movement, inducing resuscitation, Dayuan drink, pneumonia and cytokine storm, which demonstrated that we should emphasize the study on the mechanism that cytokine storm participated in and the application of Dayuan drink based on syndrome differentiation and treatment. Conclusion: In order to treat COVID-19 better, exterior-interior relation-ship between the lung and large intestine should be chosen as the guiding principle, we should regulate respiratory function and conduction function of large intestine in clinical practice, pay attention to the balance of intestinal flora, keep a normal bowel movement, and achieve the aim of simultaneous treatment of root and tip.

参考文献/References:

[1] 陈瑞,王玉光,罗亚萍,等.新型冠状病毒肺炎中医证治初探[J].河北中医药学报,2020,35(2):52-54.
[2] 仝小林,李修洋,赵林华,等.从“寒湿疫”角度探讨新型冠状病毒肺炎的中医药防治策略[J].中医杂志,2020,61(6):465-470.
[3] 肖海辉,王欣,许毅,等.SARS-CoV-2对儿童心血管系统损害的研究进展[J].中国当代儿科杂志,2020,22(4):299-304.
[3] 田朝晖,向建军,葛舰,等.清肺排毒汤治疗新型冠状病毒肺 炎理论分析与临床实践[J].世界中医药,2020,15(4):497-501.
[4] 何黎黎,龚普阳,封玥,等.中药在抗新型冠状病毒肺炎(COVID-19)引起的细胞因子风暴中的应用分析[J].中草药,2020,51(6):1375-1385.
[5] 赵娟娟,赵焕虎,赵炜,等.基于文献关键词研究我国老年人健康的热点问题[J].中国妇幼卫生杂志,2017,8(2):6-10.
[6] 令娟,樊玉清,胡兰文,等.基于CiteSpace及VOSviewer的2019新型冠状病毒研究热点的可视化分析[J].中华医院感染学杂志,2020,30(10):1468-1474.
[7] 黎家艳,李含伟,张顺萍.我国老年人再就业问题的研究热点与前沿——基于CiteSpace和VOSviewer的知识图谱分析[J].智能计算机与应用,2020,10(2):284-289.
[8] 刘京.中药有效成分对新型冠状病毒肺炎多靶点治疗作用的探讨[J].中国中西医结合杂志,2020,40(3):263-268.
[9] 许冬玉,许玉龙,王至婉,等.基于网络药理学研究清肺排毒汤治疗新型冠状病毒肺炎的作用机制[J].中药药理与临床,2020,36(1):26-32.
[10] 刘闰平,葛俊德,钟颖,等.基于干预细胞因子风暴文献挖掘的中医药治疗重症新型冠状病毒肺炎探讨[J].中草药,2020,51(5):1096-1105.
[11] 樊启猛,潘雪,贺玉婷,等.中药及其复方对病毒性肺炎的免疫调节作用研究进展[J].中草药,2020,51(8):2065-2074.
[12] 杨晨茜,瞿娇,刘怡彤,等.新型冠状病毒肺炎的免疫失衡及干预策略[J].中国药理学通报,2020,36(4):445-453.
[13] 中华人民共和国国家卫生健康委员会.截至4月27日24时新 型冠状病毒肺炎疫情最新情况[J/OL].(2020-04-26)[2020-04-26].http:://www.nhc.govcn/xcs/yqtb/202004/1c3077a1a07c4399d7c1830233ae56.shtml.
[14] 赵序茅,李欣海,聂常虹.基于大数据回溯新冠肺炎的扩散趋势及中国对疫情的控制研究[J].中国科学院院刊,2020,35(3):248-255.
[15] 罗伟康,唐涛,罗杰坤,等.中医药防治新型冠状病毒肺炎优势解析[J].中国中西医结合杂志,2020,40(3):279-283.
[16] 王宪正,赵霞,狄留庆,等.“肺与大肠相表里”的研究进展[J/OL].世界科学技术-中医药现代化:1-6[2020-04-28].
[17] 和海妍,刘伟,王云霞,等.大数据分析在智慧医疗辅助诊断中的应用与发展趋势[J].国际检验医学杂志,2019,40(13):1537-1540.
[18] 潘文,李盛华,王晓萍,等.中医对新型冠状病毒肺炎的认识与防治探讨[J].西部中医药,2020,33(4):21-24.
[19] 宋忠阳,雍文兴,张利英,等.新型冠状病毒肺炎的中医临床特征与辨证论治——甘肃经验[J].西部中医药,2020,33(3):1-5.
[20] 鲍建敏.基于“肺与大肠相表里”再认识的新型冠状病毒肺炎治疗[J].浙江中医药大学学报,2020,44(6):500-506.
[21] 朱玉,黎玉婷,姚德蛟.从中西医不同角度分析麻杏石甘汤治疗新型冠状病毒肺炎的作用[J].西部中医药,2020,33(4):5-7.

相似文献/References:

[1]景姗,王新月,杨雪,等.溃疡性结肠炎大鼠肺、肠组织中TGF-β1、SP-A表达的改变及中药的干预作用*[J].西部中医药,2014,27(03):10.
 JING Shan,WANG Xinyue,YANG Xue,et al.The Expressions of TGF-β1 and SP-A in the Lung and the Intestines of Rats with Ulcerative Colitis and TCM Intervention on the Changes[J].Western Journal of Traditional Chinese Medicine,2014,27(S1):10.
[2]李赟,王彩弟,王建云,等.简约远程中医诊疗在新型冠状病毒肺炎隔离病区中的应用[J].西部中医药,2020,33(S1):1.
 LI Yun,WANG Caidi,WANG Jianyun,et al.The Application of Simple Remote TCM Diagnosis and Treatment to COVID-19 Quarantined Inpatient Area[J].Western Journal of Traditional Chinese Medicine,2020,33(S1):1.
[3]宋忠阳,雍文兴,张利英,等.新型冠状病毒肺炎的中医临床特征与辨证论治——甘肃经验*[J].西部中医药,2020,33(S1):3.
 SONG Zhongyang,YONG Wenxing,ZHANG Liying,et al.The Experience of TCM Clinical Characteristics, Syndrome Differentiation and Treatment for COVID-19 in Gansu Province[J].Western Journal of Traditional Chinese Medicine,2020,33(S1):3.
[4]杜洪霖,马战平△.西北地区新型冠状病毒肺炎的中医特点及防治*[J].西部中医药,2020,33(S1):5.
 DU Honglin,MA Zhanping.TCM Characteristics, the Prevention and Treatment of COVID-19 in Northwest China[J].Western Journal of Traditional Chinese Medicine,2020,33(S1):5.
[5]潘文,李盛华,王晓萍,等.中医对新型冠状病毒肺炎的认识与防治探讨[J].西部中医药,2020,33(S1):7.
 PAN Wen,LI Shenghua,WANG Xiaoping,et al.On TCM Understanding, the Prevention and Treatment of COVID-19[J].Western Journal of Traditional Chinese Medicine,2020,33(S1):7.
[6]杨海侠,张银萍△,杨长虹,等.新型冠状病毒肺炎疑似患者留观隔离期的护理体会[J].西部中医药,2020,33(S1):13.
[7]丁潇,邹忆怀△,辛大永,等.北京顺义地区新型冠状病毒肺炎的中医临床证候与CT表现[J].西部中医药,2020,33(S1):16.
 DING Xiao,ZOU Yihuai,XIN Dayong,et al.TCM Clinical Syndromes and CT Manifestations of COVID-19 in Shunyi District of Beijing[J].Western Journal of Traditional Chinese Medicine,2020,33(S1):16.
[8]桑天庆,周红光△.中医药在新型冠状病毒肺炎疫情中的应用[J].西部中医药,2020,33(S1):18.
 SANG Tianqing,ZHOU Hongguang.TCM Applied to Epidemic Situation of COVID-19[J].Western Journal of Traditional Chinese Medicine,2020,33(S1):18.
[9]闫向勇,李 俊,燕忠生△.武汉地区新型冠状病毒肺炎中医证候及病机特点[J].西部中医药,2020,33(S1):20.
 YAN Xiangyong,LI Jun,YAN Zhongsheng.On the Characteristics of TCM Patterns and the Pathogenesis of COVID-19 in Wuhan Region[J].Western Journal of Traditional Chinese Medicine,2020,33(S1):20.
[10]曾建峰,李乐愚,缪灿铭,等.岭南道地药材在中山地区新型冠状病毒肺炎防治中的应用*[J].西部中医药,2020,33(S1):24.[doi:10.1056/NEJMoa-2001017]
 and Treatment of COVID-9 in Zhongshan Region.The Application of Lingnan Genuine Drugs to the Prevention[J].Western Journal of Traditional Chinese Medicine,2020,33(S1):24.[doi:10.1056/NEJMoa-2001017]

备注/Memo

备注/Memo:
*基金项目:全国第四次中药资源普查甘肃省崆峒区中药资源普查项目(GSZYPC201711)。 收稿日期:2020-06-20 *基金项目:全国第四次中药资源普查甘肃省崆峒区中药资源普查项目(GSZYPC201711)。 作者简介:高淑美(1963—),女,硕士学位,讲师。
更新日期/Last Update: 2020-09-01